Vincristine Sulfate hmoov

Chav Kawm Ntawm Tshuaj Kho Mob yog Vincristine
Vincristine sulfate hmoovyog sulfate daim ntawv ntawm vincristine. Vincristine, tseem hu ua vinblastine thiab neovinblastine, kev kho mob hu ua VCR, yog alkaloid rho tawm los ntawm periwinkle ntawm periwinkle nroj tsuag ntawm tsev neeg Apocynaceae. Vinblastine yog tsim los ntawm ob yam khoom xyaw ntuj: periwinkle, vindoline, thiab catharanthine. Nws yog monoterpene indole alkaloid (MIA). Nws yog cov tshuaj khomob uas tshwj xeeb inhibits polymerization ntawm microtubules, ib qho tseem ceeb ntawm cov cell cytoskeleton uas ua lub luag haujlwm tseem ceeb hauv mitosis (cell division). Los ntawm kev tiv thaiv microtubule sib dhos, vincristine cuam tshuam kev tsim cov mitotic spindle, yog li ntes cov hlwb hauv mitotic metaphase. Cov nyhuv no tuaj yeem ua rau cov cell tuag, tshwj xeeb tshaj yog ntawm cov cell faib sai xws li cov kab mob.
Raws li mitotic inhibitor, nws tau siv dav hauv kev kho mob los kho ntau yam pathologies, suav nrog mob lymphoblastic leukemia, mob myeloid leukemia, Hodgkin's kab mob, neuroblastoma, thiab kab mob ntsws me me. Vim nws txoj kev ua tau zoo thiab cov txheej txheem ntawm kev ua, nws feem ntau yog ib feem ntawm kev siv tshuaj khomob ua ke thiab tuaj yeem ua tiav lwm yam tshuaj khomob. Vincristine paub zoo tshaj plaws rau nws lub luag haujlwm hauv kev kho mob tseem ceeb hauv cov menyuam yaus, tshwj xeeb tshaj yog mob lymphoblastic leukemia thiab Hodgkin tus kab mob. Yog tias koj xav siv tshuaj khomob, thov hu rau Xi'an Sonwu. Xi'an Sonwu tuaj yeem muab rau koj nrog raw 99 API vincristine hmoov.

Certificate Of Analysis

Vincristine Yuav Online

Nrog ntau tshaj kaum xyoo ntawm kev paub hauv kev lag luam, Xi'an Sonwu Biotech Co. Ltd. yog tus kws tshaj lij hauv kev tsim khoom thiab faib cov khoom siv raw. Xi'an Sonwu tau tsim kev sib koom tes ruaj khov thiab vam khom nrog cov teb chaws hauv Asmeskas, Asia, Europe, thiab Oceania. Ua ntej cov khoom lag luam zoo, Xi'an Sonwu ua haujlwm nyuaj los ua kom tau raws li txhua tus neeg siv khoom xav tau los ntawm kev muab cov kev pabcuam zoo tshaj plaws.
Xi'an Sonwu ua qhov tseem ceeb ntawm kev tsim cov khoom zoo, thiab txhua yam ntawm nws txoj kev lag luam, xws li kev xaiv cov khoom siv raw, cov txheej txheem tsim khoom, cov qauv kuaj, thiab cov neeg ua haujlwm tshaj lij, cuam tshuam rau lub tuam txhab kev cog lus rau kev ua tau zoo. Los ntawm kev ua tib zoo saib xyuas txhua yam, Xi'an Sonwu tuaj yeem txiav cov nqi yam tsis muaj kev cuam tshuam zoo thiab xyuas kom cov neeg siv khoom tau txais cov khoom muaj txiaj ntsig tshwj xeeb.
Xi'an Sonwu txaus siab rau cov lus pom zoo uas nws tau txais los ntawm cov neeg siv khoom tsis tu ncua lees paub qhov siab ntawm cov khoom siv. Xi'an Sonwu ua kom cov khoom zoo thiab muab cov qauv rau koj kuaj.

Cov neeg siv khoom 'Cov lus pom zoo

Vincristine Sulfate Mechanism Ntawm Kev Ua
Lub mechanism ntawm kev txiav txim ntawm vincristine revolves nyob ib ncig ntawm nws lub peev xwm los cuam tshuam microtubule tsim. Ib qho tseem ceeb ntawm cov cytoskeleton ntawm cov hlwb, microtubules tau koom nrog ntau yam kev ua ub no, suav nrog mitosis, kev thauj mus los hauv lub cev, thiab kev saib xyuas ntawm tes. Microtubules yog qhov tseem ceeb rau kev sib cais ntawm chromosome thaum lub sij hawm mitotic theem ntawm lub voj voog ntawm tes. Nws ua haujlwm los ntawm kev khi rau tubulin, ib qho tseem ceeb ntawm microtubules. Tshwj xeeb, nws khi rau qhov kawg ntawm tubulin dimers, tiv thaiv lawv los ntawm polymerizing rau hauv microtubules. Cov nyhuv no ua rau lub mitotic spindle, tiv thaiv chromosomes los ntawm kev sib cais thaum lub sij hawm metaphase. Raws li qhov tshwm sim, cov hlwb tsis tuaj yeem ua tiav mitosis, ua rau lub voj voog ntawm tes raug ntes ntawm thaj tsam metaphase-anaphase. Qhov tsis muaj peev xwm ntawm cov hlwb los faib feem ntau ua rau apoptosis lossis programmed cell tuag, tshwj xeeb tshaj yog nyob rau hauv kev faib cov hlwb sai xws li cov kab mob.
Nws tuaj yeem cuam tshuam nrog cov metabolism hauv cov protein, inhibit qhov kev ua ntawm RNA polymerase, thiab inhibit synthesis ntawm cell membrane lipids thiab thauj cov amino acids ntawm lub cell membrane. Vincristine muaj qhov cuam tshuam loj dua rau cov kab mob hloov pauv ntau dua li vinblastine thiab muaj cov kab mob dav dav. Ntxiv rau qhov ua tau zoo tiv thaiv kab mob vinblastine-sensitive kab mob, nws kuj tseem siv tau rau nas Ridgeway osteosarcoma, Mecca lymphosarcoma, thiab X-5563 myeloma. Tsis muaj qhov sib txawv ntawm cov vincristine, vinblastine, thiab vindesine, thiab vincristine yog cov neurotoxic tshaj plaws. Tom qab siv, nws yog sai sai faib nyob rau hauv ntau yam ntaub so ntswg. Cov concentration hauv cov paj hlwb yog siab thiab tsis tshua nkag mus rau cov ntshav-hlwb barrier. Lub cerebrospinal kua concentration yog 1/30-1/20 ntawm plasma concentration, thiab protein binding tus nqi yog 75%. Hauv cov neeg laus, T1/2 tsawg dua 5 feeb, T1/2 yog 50-155 feeb, thiab lub davhlau ya nyob twg theem T1/2 yog ntev li 85 teev. Nws yog metabolized nyob rau hauv daim siab thiab muaj lub siab tshaj plaws concentration ntawm cov kua tsib. Nws feem ntau yog tawm nrog cov kua tsib, nrog rau 70% tawm hauv cov quav thiab 5%-16% hauv cov zis. Vincristine tuaj yeem xaiv mloog zoo rau hauv cov ntaub so ntswg, synchronize proliferating hlwb, thiab txhim kho cov tshuaj tiv thaiv kab mob.

Dab tsi yog Vincristine siv rau
Vincristine sulfate hmoovyog siv los kho cov mob hauv qab no:

Hodgkin's Lymphoma: Nws yog ib feem ntawm kev siv tshuaj khomob sib xyaw ua ke hu ua ABVD (Adriamycin, Bleomycin, Vinblastine, Dacarbazine), kev kho tus qauv rau Hodgkin's lymphoma.
Tsis yog-Hodgkin's Lymphoma: Vinblastine yog siv los kho ntau hom non-Hodgkin's lymphoma ua ib feem ntawm kev kho ua ke.
Kab mob Testicular: Nws tuaj yeem siv nrog lwm cov tshuaj los kho cov kab mob qog nqaij hlav, tshwj xeeb tshaj yog cov kab mob tiv thaiv kab mob thawj zaug.
Kab mob hauv lub mis: Qee zaus, vinblastine yuav siv tau rau hauv kev kho mob ntawm lub mis, feem ntau thaum lwm yam kev kho mob tsis tau zoo.
Kaposi's Sarcoma: Qhov no yog ib qho kab mob uas ua rau cov nqaij mos ntawm cov nqaij mos, nrog rau cov tawv nqaij, thiab tuaj yeem kho nrog vinblastine, tshwj xeeb tshaj yog rau cov neeg mob uas muaj kab mob AIDS ntsig txog Kaposi's sarcoma.
Lwm yam Malignancies: Vinblastine yog qee zaum siv los kho lwm yam malignancies, xws li malignant melanoma thiab zais zis, raws li ib feem ntawm kev tshawb fawb raws cai lossis thaum lwm yam kev kho mob tsis tsim nyog.

Dab tsi yog qhov tshwm sim feem ntau ntawm Vincristine
1. Dose-limiting toxicity yog lub paj hlwb toxicity, uas feem ntau ua rau peripheral paj cov tsos mob, xws li cov ntiv tes, neurotoxicity, thiab lwm yam. Nws muaj feem xyuam rau cov nyiaj cumulative-numbness ntawm cov ntiv taw, qeeb los yog tsis muaj tendon reflexes, thiab peripheral neuritis. Qee lub sij hawm, tib neeg muaj cem quav, ua tsis taus pa hauv plab hnyuv, thiab mob plab. Kev puas tsuaj rau lub cranial, lub cev muaj zog, thiab lub paj hlwb tuaj yeem ua rau cov tsos mob. Neurotoxicity feem ntau tshwm sim rau cov neeg muaj hnub nyoog 40 xyoo. Cov menyuam yaus zam tau zoo dua li cov laus. Cov neeg mob uas mob qog nqaij hlav qog nqaij hlav yog qhov ua rau mob neurotoxicity ntau dua li cov neeg mob uas muaj lwm yam kab mob.
2. Kev tiv thaiv cov pob txha thiab cov kab mob hauv plab yog me me.
3. Nws muaj cov nyhuv hauv zos-stimulating, thiab cov kua yuav tsum tsis txhob tawm. Txwv tsis pub, nws yuav ua rau lub zos necrosis.
4. Cov plaub hau poob thiab qee zaus ntawm cov ntshav siab tuaj yeem pom.

Kev sib tshuam tshuaj
1. Pyrrole series antifungal agents (itraconazole) ua rau muaj kev phiv rau cov leeg thiab lub paj hlwb. Yog tias pom muaj kev phiv tshwm sim, kev kho kom tsim nyog xws li txo koob tshuaj, kev ncua, lossis kev txiav tshuaj yuav tsum tau ua. Itraconazole tuaj yeem inhibit qhov kev ua ntawm hepatic cytochrome P-4503A, thiab vincristine metabolized los ntawm hepatocyte chromin P-4503A. Kev siv ua ke tuaj yeem cuam tshuam cov metabolism ntawm vincristine.
2. Kev siv ua ke nrog phenytoin sodium tuaj yeem txo qhov nqus ntawm phenytoin sodium los yog ua rau hypermetabolism.
3. Kev siv ua ke nrog cov platinum uas muaj cov tshuaj tiv thaiv sub thiab cov kab mob malignant tuaj yeem txhim kho lub yim khub ntawm cov hlab ntsha tawg.
4. Ua ke nrog L-asparaginase, nws tuaj yeem txhim kho cov hlab ntsha thiab cov hlab ntshav. Nws tuaj yeem muab 12 mus rau 24 teev ua ntej kev tswj hwm L-asparaginase kom txo cov tshuaj lom.

Hoobkas

1. Xi'an Sonwu Biotech Co., Ltd. muaj cov khoom muag txaus vim nws muaj lub Hoobkas tsim, ua, thiab khaws cov khoom. Xi'an Sonwu cov khoom tsim tau zoo huv si, muaj kev sib raug zoo, thiab khaws cia zoo. Cov kws tshawb nrhiav tuaj yeem tsim cov khoom tshiab, cov khoom zoo nyob hauv Xi'an Sonwu.
2. Xi'an Sonwu muaj cov lus qhia nruj me ntsis txog cov neeg ua haujlwm qib, xws li kev muag khoom thiab kev sim mus rau kev tsim khoom thiab kev sim. Rigid cov ntaub ntawv txhawb nqa thiab kev pab cuam tom qab muag tau lav tag nrho cov khoom escorting.

Daim ntawv pov thawj

Pob

Logistics

Dhau li lav cov khoom, lwm qhov tseem ceeb tshaj plaws yog cov neeg siv khoom tuaj yeem tau txais cov khoom zoo. Yog li, Xi'an Sonwu muab txhua yam kev xa khoom raws li kev xav tau sib txawv.

FAQ
Qhov ntau npaum li cas ntawm vincristine nyob rau hauv ib tug chemotherapy regimen nyob ntawm ntau yam, nrog rau hom kab mob raug kho, tus neeg mob lub cev nto cheeb tsam (BSA), tag nrho cov kev noj qab haus huv, lub raum thiab lub siab ua hauj lwm, thiab lwm yam tshuaj chemotherapy nyob rau hauv kev kho mob ua ke. Cov hauv qab no yog cov ntsiab lus dav dav ntawm kev txiav txim siab dosing:

Cov neeg laus noj ntau npaum:
Rau cov neeg laus feem ntau cov kab mob, qhov ntau npaum li cas rau nws yog 1.4 mg / m2 (mg ib square meter ntawm lub cev nto) ib lub lis piam. Txawm hais tias tus neeg mob qib BSA, qhov siab tshaj plaws txhua lub limtiam txwv ntawm 2 mg feem ntau yog qhia vim nws cov tshuaj neurotoxicity kom txo tau qhov kev pheej hmoo ntawm mob neuropathy hnyav. Cov koob tshuaj me me tuaj yeem muab ntxiv tsis tu ncua hauv qee qhov kev npaj kho mob.

Pediatric koob tshuaj:
Cov neeg mob menyuam yaus qhov koob tshuaj kuj suav nrog BSA, feem ntau siv tib lub lis piam koob ntawm 1.4 mg / m². Txawm li cas los xij, cov menyuam yaus yuav muaj qhov sib txawv ntawm qhov ntau npaum li cas raws li hnub nyoog thiab qhov loj.
Yog tias koj xav paub cov chaw tsim tshuaj tua kab mob vincristine, koj tuaj yeem tiv tauj Xi'an Sonwu. Nyem rau email, thiab tom qab ntawd koj tau txais cov khoom zooVincristine sulfate hmoov.
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