ZD6474 hmoov

Dab tsi yog Tus Qauv Ntawm ZD6474

ZD6474 hmoovyog quinazoline, uas yog 7-[(1-methylpiperidin-4-yl)methoxy]quinazoline nrog ntxiv methoxy-bromo pawg ntawm txoj haujlwm 6 thiab 4 raws li -2-fluorophenylamino hloov. ZD6474 yog tyrosine kinase inhibitor tshuaj. Qhov vascular endothelial growth factor receptor (VEGFR) inhibitor ua haujlwm los ntawm kev thaiv cov cim los ntawm cov hlwb loj hlob uas pab lawv loj hlob thiab kis tau. Vandetanib feem ntau yog siv rau qee qhov kev loj hlob uas tsis tuaj yeem kho nrog kev phais (hauv zos loj zuj zus thiab tsis tuaj yeem kho tau) lossis muaj metastasized (kis mus rau lwm qhov ntawm lub cev), xws li cov qog tsis me me hauv lub ntsws loj hlob (NSCLC) thiab qee cov thyroid loj hlob (MTC) . Vandetanib hmoov kev kho mob feem ntau ua rau kev nce siab nyob rau hauv cov ntshav aminotransferases thaum tswj hwm; Txawm li cas los xij, nws tsis cuam tshuam nrog qhov tshwm sim ntawm qhov tshwm sim ntawm qhov tshwm sim ntawm qhov tshwm sim jaundice thiab mob siab rau lub siab. Raws li kev tshawb fawb pharmacokinetic, vandetanib tau nqus tau zoo los ntawm txoj hnyuv thiab siv sijhawm li peb lub hlis kom mus txog qhov muaj zog hauv lub xeev. Peak plasma concentrations mus txog 4 mus rau 10 teev tom qab noj, thiab qhov nruab nrab plasma ib nrab-lub neej yog 19 hnub. Nws yog yuav luag nkaus xwb (90-96%) txuam nrog plasma proteins xws li albumin hauv cov ntshav. Nws yog metabolized rau N-desmethyl vandetanib los ntawm CYP3A4 thiab vandetanib-N-oxide los ntawm FMO1 thiab 3. Lawv yog tag nrho cov nquag metabolites. Cov tshuaj ZD6474 raug tshem tawm hauv nws daim ntawv tsis hloov pauv thiab nws cov metabolites muaj nyob hauv cov zis (25%) thiab quav (44%). Yog tias koj xav paub ntau ntxiv txog nws, tsuas yog hu rau Xi'an Sonwu Biotech Co., Ltd.

Certificate Of Analysis

ZD6474 Chaw tsim tshuaj paus

Xi'an Sonwu muaj ntau tshaj kaum xyoo ntawm kev tshawb fawb thiab kev tsim kho, kev tsim khoom, thiab kev muag khoom ntawm ntau yam khoom siv kho mob, sib tw nqi nrog qhov zoo tshaj plaws thiab kev pabcuam. Xi'an Sonwu yog cov kws tshaj lij Suav chaw tsim khoom ntawm cov nroj tsuag thiab kev noj qab haus huv cov ntaub ntawv raw khoom.Xi'an Sonwu Biotech Co. ltd. muaj kev paub dhau los hauv kev lag luam thoob ntiaj teb thiab kev noj qab haus huv kev lag luam. Hais txog kev ntseeg raws li kev ntseeg thiab ua ntej yog peb lub tuam txhab txoj cai. Peb nruj me ntsis tswj cov khoom zoo, uas txhais tau tias kev xaiv pib los ntawm raw khoom. Dhau li ntawd, peb lis txhua yam thiab txo tus nqi mus rau qhov siab tshaj plaws, ces peb cov neeg siv khoom tuaj yeem tau txais cov khoom lag luam zoo. Peb txaus siab muab cov kev pabcuam zoo tshaj plaws thiab cov khoom zoo rau peb cov neeg siv khoom.Raws li cov no, cov neeg siv khoom tau muab cov lus qhia zoo rau peb cov khoom. Yog li nrhiav Xi'an Sonwu Biotech Co. Ltd. thaum yuav nws.

Xi'an Sonwu tag nrho ua kom cov khoom zoo, yog li cov qauv tuaj yeem muab tau. Ntawm no yog qhov ntau.

Cov neeg siv khoom zoo lus

Dab tsi yog Mechanism Ntawm Kev Ua Ntawm ZD6474

ZD6474 tau pom zoo los ntawm FDA rau kev kho mob ntawm cov neeg laus cov neeg mob uas tsis tuaj yeem kho tsis tau, hauv cheeb tsam siab, lossis metastatic medullary thyroid loj hlob rau lub Plaub Hlis 6, 2011. Cov kws tshawb fawb pom tias nws muaj qhov nruab nrab bioavailability ntawm 21.4%. ZD6474's mechanism ntawm kev txiav txim yog raws li ib tug protein kinase inhibitor los ntawm occupying lub ATP adenine khi qhov chaw uas nws tsim ib tug hydrogen daim ntawv cog lus nrog nws cov N-1 nitrogen thiab cov protein's Cys-912 residue. Cov tshuaj no ua haujlwm los ntawm kev thaiv qee cov proteins hauv lub cev uas pab cov hlwb loj hlob thiab kis tau. Los ntawm inhibiting cov proteins no, vascular endothelial kev loj hlob zoo (VEGF) RTK yog thaiv nyob rau hauv vitro angiogenesis qauv, thiab epidermal loj hlob zoo tshaj plaws (EGF) RTK-nyob cell ciaj sia taus yog inhibited nyob rau hauv vitro. Thaiv VEGF receptors txwv kev tsiv teb tsaws ntawm tes, kev loj hlob, kev muaj sia nyob, thiab kev loj hlob ntawm cov hlab ntsha tshiab, uas yog qhov tseem ceeb rau kev txhawb nqa kev loj hlob ntawm canker. Vandetanib hmoov pab qeeb lossis nres kev loj hlob ntawm cov kab mob canker, yog li ncua kev loj hlob ntawm tus kab mob.

ZD6474 Dose

ZD6474 hmoovyog muab 300 mg PO txhua hnub (nrog lossis tsis muaj zaub mov) kom txog thaum muaj kab mob kis los yog tsis muaj tshuaj lom.

Txo koob tshuaj

Qib Siab dua lossis sib npaug ntawm 3 toxicity: Txo rau 200 mg ib hnub; tom qab ntawd ntxiv txo mus rau 100 mg ib hnub yog tias tsim nyog

cuam ​​tshuam kev kho mob

Corrected QT interval, Fridericia (QTcB) interval >500 msec: rov pib dua koob tshuaj ib zaug QTcF Tsawg dua lossis sib npaug rau 450 msec

Qib Siab dua lossis sib npaug rau 3 toxicity: Thaum toxicity txo mus rau

Recurrent toxicity: Yog xav tau kev kho mob ntxiv, txo qhov koob tshuaj rau 100 mg ib zaug toxicity txo mus rau

lub raum insufficiency

CrCl Ntau dua lossis sib npaug li 50 mL / min: Tsis tas yuav tsum tau hloov koob tshuaj

Nruab nrab (CrCl 30 rau<50 mL/min): Reduce starting dose to 200 mg PO qDay

Mob hnyav (CrCl<30 mL/min): Not recommended

Cov kab mob hauv lub raum kawg uas yuav tsum tau lim ntshav: tseem tsis tau kawm

daim siab puas

Mild (Child-Pugh A): Tsis muaj kev hloov kho ntau npaum li cas tau piav qhia hauv cov chaw tsim khoom daim ntawv lo

Nruab nrab mus rau hnyav (Child-Pugh B lossis C): Tsis pom zoo

ZD6474's anti-RET kev txiav txim yog resistant rau RET mutation V804M.

Vandetanib yuav tsum tsis txhob siv los ua thawj kab ntawm kev kho mob rau cov neeg mob uas QTcF ncua sijhawm ntev dua 450 msec. ZD6474 yuav tsum tsis txhob muab rau cov neeg mob uas muaj keeb kwm ntawm bradyarrhythmias, congenital long QT syndrome, torsade de pointes, los yog decompensated plawv tsis ua hauj lwm. Nco ntsoov tias nws yog ib qho tshuaj uas yuav tsum tau noj raws li kws kho mob saib xyuas xwb. Nws yog ib qho tseem ceeb kom ua tib zoo ua raws li koj tus kws kho mob cov lus pom zoo thaum siv ZD6474 thiab tshaj tawm cov tsos mob tsis zoo lossis kev tshwm sim. Zoo li txhua yam tshuaj, qhov no tuaj yeem muaj qhov cuam tshuam tsis zoo thiab cuam tshuam nrog lwm cov tshuaj.

ZD6474 Cov Kev Pab Cuam Tshuam

Ntawm 100 tus neeg tau txais Vandetanib, ntau tshaj 20 thiab txog 100 yuav muaj:
Ntshav siab tuaj yeem ua rau kiv taub hau, thiab qhov muag tsis pom kev.
Mob plab, xeev siab, tsis qab los noj mov.
Mob plab.
Kev nkees.
Mob taub hau.
Pob txuv, pob khaus, tawv nqaij qhuav, hloov ntawm cov rau tes, ua rau muaj kev pheej hmoo ntawm tshav kub.

Hoobkas ib puag ncig

Xi'an Sonwu ntau lawm Hoobkas yog zoo-tsim, huv si, thiab huv si, nrog txaus Tshuag. Raws li kev coj noj coj ua ntawm lub tuam txhab, cov kws tshawb fawb tau hais kom tsim cov khoom tshiab. Cov hauv qab no yog qhov chaw sim ntawm peb lub chaw soj nstuam, cov cuab yeej ntsuas qib siab, thiab cov kws tshaj lij kev sim, nrog tus cwj pwm nruj los muab cov ntaub ntawv tseem ceeb rau peb cov khoom thiab muab peb cov neeg siv khoom nrog kev paub zoo.

Daim ntawv pov thawj

Ntim

Logistics

Ntxiv nrog rau kev lees paub cov khoom zoo, lwm qhov tseem ceeb tshaj plaws yog cov neeg tuaj yeem tau txais cov khoom lag luam zoo. Yog li, Xi'an Sonwu muab txhua yam kev xa khoom raws li kev xav tau sib txawv.

Vim Li Cas Xaiv XI'an Sonwu

1. Zoo tshaj plaws

Xaiv cov khoom siv raw zoo tshaj plaws, thiab nrog kev pab ntawm cov cuab yeej tshaj lij thiab pab pawg tshawb fawb, xyuas kom cov khoom zoo tshaj plaws.

2. Kev pabcuam OEM

Tsis tsuas yog hmoov cov khoom, tab sis kuj customized cov khoom yuav muab, xws li customized capsules shells, customized fwj, customized ntim thiab customized daim ntawv lo. Nrog kev nplua nuj ntawm OEM, Xi'an Sonwu lav zoo xa tuaj raws sijhawm nrog cov khoom siab.

3. Kev pabcuam zoo

Ntau tshaj 10- xyoo kev ua lag luam ua rau Xi'an Sonwu tuaj yeem pab cov neeg siv khoom daws txhua yam teeb meem, thiab muab cov kev pabcuam tshaj lij ua ntej thiab tom qab muag, xyuas kom cov neeg siv khoom tau txais cov khoom zoo.

4. Lub zog muaj zog

Peb muaj peb tus kheej tsim kev cob qhia thiab OEM Hoobkas, thiab lab.

5. Muaj kev paub

Ua lag luam xa tawm mus rau thoob plaws ntiaj teb rau ntau tshaj 8 xyoo.

6. Pab neeg tshaj lij

Muaj cov R & zoo meej, pab pawg muag khoom thiab pabcuam.

7. Kev Pabcuam Siab Siab

Muaj zoo meej R &, kev muag khoom thiab pab neeg ua haujlwm.Muaj nyob rau hauv kev lag luam rau ntau xyoo, cov neeg siv khoom qhuas tau mus txog 99%.

8. Cov neeg siv khoom tshuaj xyuas

Tau nyob hauv kev lag luam ntau xyoo, cov neeg siv khoom qhuas tus nqi tau mus txog 99%.

Thiab yog tias koj xav paub covZD6474 hmoovnqe, thov hu rau XI'an Sonwu.

Email:sales@sonwu.com

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