Linaclotide hmoov

Linaclotide Peptide Description
Linaclotide hmoov, polypeptide muaj 14 amino acids, yog Tuam Tshoj tus thawj coj mus muag agonist rau plab hnyuv epithelial hlwb guanylate cyclase C (GC-C). Nws cov txheej txheem ntawm kev ua yog txawv ntawm cov kws kho mob IBS-C uas twb muaj lawm, thiab nws tuaj yeem txhim kho cov neeg mob cov tsos mob zoo. Nws tuaj yeem kho cem quav cem quav (IBS-C) thiab mob plab idiopathic constipation (CIC). API linaclotide yog ib qho guanylate cyclase C agonist uas khi rau txoj hnyuv GC-C, uas ua rau kom siab intracellular thiab cGMP concentrations. Nce intracellular cGMP tuaj yeem tsim cov kua dej hauv plab hnyuv, ua kom lub plab zom mov, thiab yog li ua kom muaj qhov tso zis ntau zaus. Kev nce qib ntawm extracellular cGMP tuaj yeem txo qhov rhiab heev ntawm cov hlab ntsha ntawm qhov mob thiab txo qhov mob plab. Nws yog thawj cov tshuaj los kho cem quav nrog cov txheej txheem ntawm kev txiav txim. Tsis tas li ntawd, nws yog oligopeptide agonist rau guanylate cyclase 2C thiab tseem nyob hauv plab hnyuv tom qab noj qhov ncauj. Nws cov khoom degradation feem ntau yog faib rau hauv lub plab zom mov, yog li nws tsis tshua ua rau lub raum thiab lub siab puas tsuaj, thiab nws cov txiaj ntsig tsis cuam tshuam los ntawm daim siab thiab lub raum ua haujlwm. Linaclotide tsis tshua ua rau lub raum thiab lub siab puas tsuaj txhua hnub, yog li yog tias koj txaus siab rau cov lag luam wholesale linaclotide, thov hu rau Xi'an 'Sonwu.

Certificate of Analysis

Qhov twg Yuav Linaclotide
Xi'an Sonwu Biotech Co., Ltd. yog ib lub chaw tsim khoom thiab distributor nrog ntau tshaj kaum xyoo ntawm kev paub. Nws muaj kev koom tes dav thiab ruaj khov nrog cov teb chaws thoob ntiaj teb hauv Asmeskas, Asia, Europe, thiab Oceania. Xi'an Sonwu yeej ib txwm hais rau cov khoom zoo ua ntej. Pab txhua tus neeg siv khoom zoo thiab txaus siab rau txhua tus neeg siv khoom yog Xi'an Sonwu txoj kev nrhiav. Xi'an Sonwu nruj me ntsis tswj txhua kauj ruam, los ntawm kev xaiv cov khoom siv raw thiab nrhiav cov khoom zoo los ntawm txhua yam, xws li kev xaiv cov khoom siv, kev tsim khoom, kev kuaj cov qauv, thiab cov neeg ua haujlwm tshaj lij. Tsis tas li ntawd, Xi'an Sonwu siv zog ua txhua yam kom txo tau cov nqi thiab tso cai rau cov neeg siv khoom kom tau txais cov khoom lag luam nrog cov nqi siab. Raws li cov no, cov neeg siv khoom tau muab cov lus pom zoo ntawm cov khoom. Yog li yog tias koj xav tau API linaclotide, thov hu rau Xi'an Sonwu.
Xi'an Sonwu nkaus ua cov khoom tshwj xeeb zoo thiab muab cov qauv. Ntawm no yog qhov ntau.

Cov neeg siv khoom 'Cov lus pom zoo

Dab tsi yog Linaclotide siv rau
1. Sab hauv lub cev ua kom lub cev muaj zog thiab tso zis

Linaclotide hmoovtuaj yeem ua rau kom cov tshuaj chloride thiab bicarbonate nyob rau hauv cov hnyuv me thiab thaum kawg ua kom cov kua hauv plab hnyuv loj, nce tus nqi ntawm cov hnyuv hloov, thiab lwm yam., kom ua tiav cov nyhuv tso zis, txo qhov mob plab, thiab lwm yam. Yog tias txoj hnyuv tsis huv, nws yuav cuam tshuam rau txoj hnyuv mucosa qhov kev soj ntsuam kom txoj kev colonoscopy tuaj yeem tau txais txiaj ntsig zoo. Linaclotide tuaj yeem pab cov neeg mob kom defecate thiab ntxuav cov hnyuv, yog li nws kuj tuaj yeem siv los ua tshuaj ua ntej colonoscopy. Linaclotide thiab nws cov metabolites nquag ua rau cystic fibrosis cross-membrane hloov pauv hloov pauv (CFTR). CGMP intracellular CGMP tuaj yeem ua rau kom muaj cov tshuaj chloride thiab bicarbonate nyob rau hauv cov kab noj hniav me me thiab nws thiaj li ua rau cov kua hauv plab me me thiab cov hnyuv.

2. Kev kho mob plab hnyuv syndrome thiab alleviating cov kab mob ntawm flora nyob rau hauv txoj hnyuv

Irritable plob tsis so tswj syndrome feem ntau yog tshwm sim los ntawm kev sib xyaw ua ke ntawm kev puas siab puas ntsws thiab lub cev qhov kev ntxhov siab. Ntau tus neeg mob yuav raug cuam tshuam los ntawm caj ces, ib puag ncig, puas siab puas ntsws, lossis kev sib raug zoo, ua rau muaj kev hloov pauv hauv plab. Cov khoom xyaw hauv cov tshuaj feem ntau yog linaclotide. Cov tshuaj no belongs rau agonist ntawm guanylate cyclase C. Los ntawm kev siv cov tshuaj, thiab nws muaj peev xwm ua kom cov dej hauv cov hnyuv thiab ua tiav cov nyhuv lubricating ntawm txoj hnyuv. Tsis tas li ntawd, nws tseem tuaj yeem ua rau cov quav mos thiab ua kom cov quav tso tawm du. Nws tuaj yeem txhawb nqa cov kua dej hauv cov hnyuv thiab nce thiab txhawb cov peristalsis ntawm plab hnyuv du, uas yog qhov zoo rau kev txhim kho cem quav. Tshwj xeeb tshaj yog nyob rau hauv kev thaj yeeb nyab xeeb, vim tsis muaj kev tawm dag zog lossis kev noj zaub mov tsis zoo, nrog rau cov tsos mob cem quav, kev siv cov tshuaj no rau kev kho mob, cov nyhuv yog pom tseeb. Cov neeg mob kuj yuav tsum tau haus dej sov ntau dua los kho cov kab mob siv linaclotide, uas tuaj yeem ua tiav cov txiaj ntsig ntawm cov hnyuv ntub dej zoo dua.

Dab tsi yog Cov Txheej Txheem Ntawm Kev Ua Ntawm Linaclotide
1. Cov txheej txheem rau kev kho cem quav
Linaclotide activates GC-C receptor, thaum GC-C receptor yog tus ntoo khaub lig-membrane receptor tsuas yog qhia hauv plab hnyuv epithelial hlwb. Nws tuaj yeem sib xyaw nrog cov kab mob endogenous, kab mob enterotoxin, thiab cov khoom siv hluavtaws. Ua kom cov concentration ntawm CGMP hauv cell, thiab txhawb phosphorylation ntawm cov protein kinase II (CGMP-DependentProteinKinase Ⅱ (PKG-Ⅱ) (CGMP-DependentProteinKinaSe Ⅱ). PKG-Ⅱ phosphorylation tuaj yeem tswj hwm cystic fibrosis cross-membrane kis cov cai tswj hwm (CFTR), cuam tshuam rau plab hnyuv epithelial hlwb 'ion khov kho. yog CAMP-activated ATP qhov rooj-tswj anion xaiv channel, uas qhia rau saum npoo ntawm cov hnyuv epithelial hlwb. Kev tso tawm ntawm chloride thiab bicarbonate ions kom cov sodium ion yog passively xa mus rau lub extracellular vim ion gradient, uas kuj prompts cov dej molecular permeability rau passively koom nrog t. nws extracellular, uas yuav ua rau kom nce nyob rau hauv cov hnyuv ua kua. Accelerate gastrointestinal migration, yog li ua kom cov quav ntau zaus.

2. Cov txheej txheem kho mob plab
Linaclotide tuaj yeem kho cov hnyuv rhiab heev tom qab ua kom cov receptor, thiab ua kom GC-C tuaj yeem txhim kho cov ntsiab lus ntawm cyclo nyiaj laus hauv lub cell. Thaum cov ntsiab lus ntawm CGMP sab hauv hlwb nce, lub twj tso kua mis sab nraud uas tuaj yeem kho tau los ntawm ntau cov tshuaj tiv thaiv kab mob protein (MRP) 4 lossis 5 tuaj yeem hloov mus rau sab nraud ntawm tes. Qhov siab ntawm extracellular CGMP concentration tuaj yeem cuam tshuam qhov kev zoo siab ntawm cov hlab ntsha tseem ceeb ntawm txoj hnyuv thiab txo qis kev tso tawm ntawm cov neurotransmitters, yog li inhibiting kev sib kis ntawm qhov mob thiab impulse thiab mob rhiab heev. Nws tuaj yeem ua ib feem ntawm GC-C los txhim kho cov ntsiab lus ntawm extracellular CGMP, txhim kho VH ntawm cov neeg mob IBS-C, nce qhov mob, thiab tom qab ntawd txo qhov mob plab. Tsis tas li ntawd, cov hlab ntsha peripheral muaj cov pob txha thiab medullary-dawb sheath fiber, glutamate receptors tam sim no, thiab ionic glutamate receptors kuj koom nrog tsim kev ua xua. Cov kev tshawb fawb tau pom tias extracellular CGMP tuaj yeem cuam tshuam cov lus teb rau ionic glutamic acid receptors. Linaclotide tuaj yeem txo qhov mob los ntawm kev nce siab ntawm CGMP hauv lub voj voog thiab los ntawm cov hlab ntsha.

Dab tsi yog Cov Teeb Meem Ntawm Linaclotide
1. Kev kho mob ntawm API linaclotide plab hnyuv excitement syndrome Cov kab mob plab hnyuv: raws plab, mob plab, plab hnyuv demodulation, plab mob plab, kab mob enteritis, thiab mob taub hau.

2. Kev kho mob tshwj xeeb constipation Feem ntau tus qauv: raws plab, mob plab, plab hnyuv plab, plab plab, kab mob ua pa sab sauv, sinusitis, qee zaus plab zom mov, quav quav, kab mob plab, plab hnyuv, thiab urticaria.

Hoobkas
1. Xi'an Sonwu Biotech Co., Ltd muaj nws lub Hoobkas los tsim, tsim thiab khaws cov khoom, yog li muaj Tshuag txaus. Xi'an Sonwu muaj kev txiav txim kom zoo, huv si, thiab huv si ntau lawm. Nyob rau hauv Xi'an Sonwu, cov kws tshawb fawb tuaj yeem tsim cov khoom tshiab zoo.
2. Xi'an Sonwu muaj cov cai nruj rau cov neeg ua haujlwm faib los ntawm kev tsim khoom thiab kev sim rau kev muag khoom. Txhawm rau kom ntseeg tau tias txhua yam khoom raug thauj mus los, kev txhawb nqa cov ntaub ntawv nruj thiab kev pabcuam tom qab muag tau muab.

Daim ntawv pov thawj

Ntim

Logistics

Dhau li lav cov khoom, lwm qhov tseem ceeb tshaj plaws yog cov neeg siv khoom tuaj yeem tau txais cov khoom zoo. Yog li, Xi'an Sonwu muab txhua yam kev xa khoom raws li kev xav tau sib txawv.

FAQ
1) Constipation ntawm plab hnyuv excitement syndrome:
Cov koob tshuaj pom zoo yog 290 mcg / zaug, ib hnub / sijhawm, thiab noj lub plab khoob tsawg kawg 30 feeb ua ntej hnub thawj pluas noj.
2) Chronic constipation:
Cov koob tshuaj pom zoo yog 145 mcg / sijhawm, ib hnub / sijhawm, thiab noj lub plab khoob tsawg kawg 30 feeb ua ntej hnub thawj pluas noj.
Yog tias koj xav paub tus neeg muag khoom linaclotide, koj tuaj yeem tiv tauj Xi'an Sonwu. Nyem rau email ces koj tau txais high-zoolinaclotide hmoov.
Email:sales@sonwu.com

Cim npe nrov: linaclotide hmoov, Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, ntshiab, raw, mov, kev muag khoom