Emtricitabine APIUa si lub luag haujlwm tseem ceeb li cov neeg saib xyuas uas ntsiag to tiv thaiv kab mob kis tus kab mob. Raws li tus tswv cuab tseem ceeb ntawm lub nucleoside rov qab cov inhibitor (NRTI) tsev neeg, nws tsis yog lub pob zeb tiv thaiv kev sib xyaw ua ke rau cov neeg siab. Cia peb mus saib ze li cas emtricitabine precisely phiaj hom kab mob thiab kev hloov pauv hloov pauv nws yog coj mus rau tib neeg kev noj qab haus huv. Yog tias koj xav yuav emtricitabine, thov hu rau Xi'an Sonwu; Xi'an Sonwu tuaj yeem muab thiab npaj khoom xa tuaj.
Dab tsi emtricitabine
Cov tshuaj antiviral emtricitabine yog feem ntau siv los kho tus kabmob HIV, ob qho tib si rau kev tiv thaiv thiab kho tus kabmob HIV hauv cov neeg laus. Nws kuj yog siv qee kis los kho tus kab mob siab B. Nws yog rau Nucleoside CrackSase inhibitor (NRTI) chav kawm. Nws tseem txhim kho cov keeb kwm kev sib txawv, piv txwv, thiab cov tsis muaj zog thiab muaj kev nyab xeeb thaum kho.
Nws thaiv tus kabmob HIV los ntawm cov khoom siv caj ces los ntawm Transcriptase rov qab, yog li tiv thaiv kev sib kis tus kab mob proval. Nws ua mimics lub tsev thaiv DNA. Thaum tus kabmob sim ua kom nws cov khoom siv caj ces, cov tshuaj tau sib xyaw rau hauv cov saw zuj zus DNA saw hlau. Qhov kev sib xyaw ua ke no muaj peev xwm ua kom muaj peev xwm txuas ntxiv, ua kom tiv thaiv tus kab mob kis ntxiv, thiab txo tus kab mob kis hauv lub cev.
Yuav ua li cas emtricitabine ua haujlwm
Emtricitabine feem ntau yog siv los kho cov kab mob HIV thiab tus kabmob siab B (HBV). Nws dag tus kab mob rau hauv kev siv lub tsev tsis zoo thaum sim ua kom nws cov khoom siv caj ces. Thaum cov teeb meem lub tsev tsis xws luag yog ntxiv, cov txheej txheem kev hloov ua haujlwm hauv cov ntawv luam tawm tshiab. Nws ua raws li txoj saw terminator thaum ntau lawm cov khoom lag luam DNA.
Lub tshuab kev ua yog raws li hauv qab no:
1. Lub tsev block mimicry. Tshwj xeeb, nws mimics cytidine, ib qho ntawm cov vaj tsev lub tsev thaiv (nucleosides) ntawm DNA.
2. Kev ua kom zoo. Ib zaug hauv sab hauv kis cov neeg mob hlwb, emtricitabine yuav tsum ua kom tiav. Cellular enzymes ntxiv pawg phosphot rau nws, hloov nws mus rau nws daim ntawv nquag, emtricitabine triphosphate.
3. Hauv lub xov tooj ntawm tes, nws daim ntawv nquag (emtricitabine Triphosphate) sib tw nrog lub ntuj nucleotide deoxycytidine triphosphate (DPTP).
4. Nws sib koom ua ke ua kis phom DNA. Thaum HIV lossis HBV sim theej theej theej tawm hauv tib neeg lub hlwb, nws tso cai rau tus kis tus kab mob kis tseem ceeb hu ua transcriptase. Qhov kev ua yeeb yam enzyme no yog tsim cov kab mob DNA ntawm tus kab mob RNome (nyob rau hauv cov kab mob HIV (nyob rau hauv cov RNA ua ntej Pre- genome rau hauv DNA (nyob rau hauv cov ntaub ntawv ntawm HBV). Rov Qab Transcriptase yuam kev xaiv emtricitabine TriphosphathPhate hloov DVSPLING DPTP thiab koom nrog nws mus rau hauv cov saw loj zuj zus DNA.
5. Saw txiav. Qhov no yog qhov ruam tseem ceeb. Nws tsis muaj cov pab pawg ua haujlwm tseem ceeb (3 '- hydroxyl) pom hauv ntuj nucleosides. Cov pab pawg no yog qhov tseem ceeb rau kev hloov pauv rov qab xa cov nucleotide ntxiv hauv cov saw hlau. Vim tias tsis muaj cov pab pawg no, ib zaug ntxiv, DNA saw tsis txuas ntxiv mus ntxiv, yog li prescaturely halting kis synthesis.
6. Thaiv cov kab mob kis. Yog tsis muaj daim ntawv luam tawm thiab ua haujlwm tsis tau, tus kabmob tsis tuaj yeem sib xyaw rau hauv lub xov tooj ntawm tes DNA lossis ua cov kab mob tshiab kis. Qhov no siv tau HIV lossis HBV replycle lub voj voog hauv lub xov tooj ntawm tes.
Dab tsi yog cov txiaj ntsig ntawm emtricitabine
Kev kho mob HIV (tib neeg cov kab mob txhaj tshuaj tiv thaiv tib neeg nyob rau ntawm cov tshuaj no antiretroveiral. Nws siv muaj ntau yam txiaj ntsig, ob qho tib si hauv kev kho tus mob uas twb muaj lawm thiab hauv kev tiv thaiv lawv. Cov hauv qab no yog nws cov txiaj ntsig.
1. Kev kho mob HIV zoo.
Ua ib feem ntawm kev kho kev kho, nws yog qhov tseem ceeb rau kev tswj hwm HIV muaj txiaj ntsig zoo. Thaum siv nrog lwm cov tshuaj antiretroviral, nws pab ua kom muaj lub nra tsis muaj zog thiab boosts tsis muaj zog.
2. Tiv thaiv cov nyhuv (prep).
Nws yog qhov tseem ceeb ntawm prep, ib txoj kev tiv thaiv rau cov tib neeg ntawm kev pheej hmoo ntawm HIV kev kis tus kabmob HIV. Kev siv tsis tu ncua muaj peev xwm txo qhov kev pheej hmoo ntawm tus kabmob HIV hauv kev pheej hmoo siab nyob rau hauv high- txoj kev pheej hmoo.
3. Cov txiaj ntsig kev nyab xeeb profile.
Piv nrog rau lwm cov tshuaj antiretroviral, nws yog feem ntau zoo tsim nyog rau thiab muaj qee qhov kev mob tshwm sim.
4. Txo cov kab mob tsis kam.
Thaum tsis kam tuaj yeem tsim nrog txhua yam tshuaj antiretroviral, qhov tshwm sim ntawm kev sib hloov tsis tshua muaj kev sib hloov yog qhov tsawg kawg nkaus thaum cov khoom lag luam no tau siv ua ke nrog lwm cov tshuaj.
5. Versatile Dosage Try
Tuaj yeem siv ua ke nrog lwm cov tshuaj antiretroviral. Qhov no ua kom yooj yim kho cov regimens thiab txhim kho kev ua raws.
6. Ntev ib nrab - lub neej
Cov tshuaj no ntev ib nrab - lub neej tswj hwm nws cov hauj lwm zoo thiab txo qhov ntxim nyiam ntawm cov koob tshuaj. Qhov no cov ntaub ntawv xovtooj no ua rau nws cov hauj lwm zoo, tshwj xeeb hauv kev kho ua ntej.
7. HIV RNA RANNESS
Txo cov khaub ncaws hnav. Cov tshuaj no ua rau muaj ntshav HIV, ua rau lub hom phiaj ntawm cov kev txwv ntawm kev noj qab haus huv thiab txo qis kev pheej hmoo ntawm kev kis tau.
8. Kev tiv thaiv lub cev tsis muaj zog
Nws pab tswj hwm lossis nce CD4 t cell suav, uas yog qhov tseem ceeb rau kev tswj hwm kev noj qab haus huv tag nrho thiab zoo}- tus kheej zoo. Nws muaj cov txiaj ntsig zoo hauv kev kho thiab tiv thaiv tus kabmob HIV. Nws lub luag haujlwm hauv kev ua ke kho thiab pre - Tshaj tawm cov Prophylaxis (prepores kev nyab xeeb profile thiab kev ua kom haum HIV kev tswj hwm. Rau cov tib neeg muaj kev pheej hmoo rau lossis kis tus kabmob HIV, nws muab kev tiv thaiv kab mob rau cov kab mob thiab cov teeb meem.
Txog kev nug txog emtricitabine APTING, txaus siab rau Xi'an Songwu, lossis lwm cov lus nug khoom, thov hu rau Xi'an Sonwu ncaj qha.
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