Puas yog Trelagliptin qhov kev kho mob zoo rau cov ntshav qab zib rau koj? Xav hauv siab, tsis tas yuav nco ntsoov nco ntsoov. Suab yooj yim, txoj cai? Nws pab tswj cov hlab ntshav khov kho thaum txo qis kev pheej hmoo ntawm hypoglycemia. Kab lus no yuav delve ntxaum rau hauv nws cov tshuab kev ua thiab uas yuav tsum txiav txim siab noj nws.
Dab tsi yog 99 trelagliptin
99 Telagliptin HmoovYog cov tsiaj hmoov ntawm Trelagliptin, feem ntau siv los kho Hom 2 Ntshav Qab Zib. Nws yog dipeptidyl peptidase - 4 (dpp {}} 4) inhibitor, tshaj tawm "kev rau txim rau kev phem thiab kev txhawb nqa zoo thiab txhawb kom zoo." Ib qho tseem ceeb ntawm cov khoom no yog nws cov khoom siv sib txawv ntawm cov dPP-4 inhibitors, txhim kho tus neeg mob ua kev ua raws. Nws siv tau cov dej qab zib kom huv si kom qab cov ntshav qab zib Postprandial incrandins txhim kho pancreatic borcreatic borcreatic borge rhiab, txhawb kev zais pa insulin, thiab tsis muaj txiaj ntsig zoo ntawm cov ntshav qab zib. Hauv kev sim tshuaj mob, cov tshuaj no tau ua kom pom cov ntshav zoo heev - txo qis kev ua tau zoo thiab kev nyab xeeb. Tsis tas li ntawd, nws muaj tsawg kawg rau lub cev hnyav thiab yog kev nyab xeeb rau cov hlab plawv, ua rau nws haum rau kev kho mob ntshav qab zib ntev. Yog tias koj txaus siab rau Trelagliptin, thov hu rau Xi'an Soniau.
Dab tsi yog cov tshuab ntawm kev ua ntawm Trelagliptin
Trelagliptin txhim kho Glycicic tswj hauv cov neeg mob muaj ntshav qab zib hom 2 -}}}}. Nws ntev {{{}}} kav ntev dpp {}}}}} kev nqis tes thiab kev kho kom zoo rau hom 2 ntshav qab zib. Nws qhov tshwj xeeb pharmacokinetics pab txhawb Glycemic tswj nrog kev phiv tawm tsawg. Cov ncauj lus kom ntxaws tshuaj xyuas ntawm nws cov tshuab ntawm kev ua yog raws li hauv qab no.
1. Kev cuam tshuam ntawm DPP -} 4 enzyme. Nws rov qab thiab sib tw khi rau dPP - 4 enzyme, yog li thaiv nws cov haujlwm. Qhov inhibition zoo tiv thaiv kev tsis txaus siab ntawm cov tshuaj hormones sai sai, suav nrog Genp-1 (glucagon-zoo li peptide-1) thiab gip (qab zib roj shoulin zais cia polypepride).
2. Lub caij nyoog ntawm Incretin kev ua haujlwm. Cov tshuaj hormones hormones intertretin yog tso tawm los ntawm cov hnyuv tom qab noj zaub mov thiab feem ntau muaj ib nrab hnub noj mov (1 {} lub neej (1}} lub neej (1}} 2 feeb) vim yog DPP-4. Trelagliptin ua haujlwm los ntawm kev ntsuas nws cov haujlwm, yog li txhim kho insulin zais pa thiab cov piam thaj glucose los ntawm cov nqaij pancreatic. Trelagliptin tseem inhibits glucagon tso tawm los ntawm pancreatic cell (txo cov hepatic qabzum ntau lawm). Trelagliptin tseem muaj cov nyhuv me (ntawm GLP-1) los ntawm kev ua kom qeeb qeeb, pab txo cov ntshav ntshav qab zib.
3. Cov kua nplaum - beurse nyhuv. Nws cov ntsiab lus tseem ceeb yog tias nws yog glucose -} Nyob ntawm qhov tsis txaus ntseeg tsuas yog ua kom ntshav qab zib (xws li tom qab noj mov). Nws kuj tseem tsawg txoj kev pheej hmoo ntawm hypoglycemia, yog li nws cov txiaj ntsig zoo li cov ntshav muaj ntshav qab ntshav qab zib rov qab.
4. Nws cov tshuaj pharapacokinetics muab cov nyhuv muaj zog, nrog rau kev sib cais qeeb los ntawm DPP-4 (kwv yees li 30 feeb, piv rau ob peb feeb rau lwm tus DPP-4 inhibitors). Qhov no pab txhawb kev ruaj khov tiv thaiv enzymatic degradation.
Dab tsi yog lub sijhawm ntawm kev ua ntawm Trelagliptin
Ib nrab - lub neej ntawm Trelagliptin yog kwv yees li 54.3 teev. Qhov ntev ib nrab ib nrab- lub neej txo cov koob tsheej ntau, lub ntsiab lus tias cov ntshav ntau yuav siv sijhawm li peb hnub rau Halve. Vim tias cov tshuaj muaj qhov kev tshem tawm tsawg heev, nws yog excreted zoo tsis hloov pauv los ntawm ob lub raum, ua rau muaj kev tshem tawm qeeb qeeb tshaj li cov tshuaj sib xws. Nws khi nruj nreem rau DPP-4 enzyme thiab cov khoom ua pov thawj qeeb dua li ntawm lwm tus DPP-4 inhibitors, xws li sitagliptin (3.5 feeb) lossis vildagliptin (<2 minutes). This significantly improves patient convenience and compliance, contributing to its sustained efficacy.
Cov tshuaj cov qauv tshuaj tiv thaiv kev tiv thaiv metabolic tsis txaus siab, ua rau metabolic ruaj khov thiab lub sijhawm ntev ntawm kev nqis tes ua. Hauv kev tshawb nrhiav kev coj ua, qhov no txuas ntxiv ib nrab - Lub neej tuaj yeem txo cov ntshav qab zib kom txo qis kev ua si ntawm cov kev ua ub no (glp}} 1 / gip). Hauv kev sib piv, qee qhov kev tshawb fawb tau pom ntau qhov ntau ntawm ib nrab ntawm lub neej, txij li 95 teev, vim muaj kev sib txawv ntawm cov tib neeg ntawm cov tib neeg; Txawm li cas los xij, tus nqi kev pom zoo yog nyob ib ncig ntawm 54 teev.
Dab tsi yog cov kev cuam tshuam ntawm cov tshuaj Trelagliptin
Trelagliptin yog qhov pom dav dav rau nws qhov ua tau zoo hauv kev kho ntshav qab zib. Nws ua haujlwm los ntawm kev tswj cov ntshav qab zib. Txawm hais tias Trelagliptin ua haujlwm tau zoo rau kev tswj cov ntshav qab zib, nws yog ib qho tseem ceeb kom muaj kev pom zoo ntawm cov kev mob tshwm sim.
1. Ib qho ntawm cov kev mob tshwm sim feem ntau yog cov kev ntxhov siab hauv plab. Qhov no tuaj yeem suav nrog cov tsos mob xws li xeev siab thiab ntuav. Mob plab tsis xis nyob thiab raws plab. Cov tsos mob no feem ntau yog tsawg tsawg thiab zoo li ploj mus ntawm lawv tus kheej li lub cev hloov mus rau cov tshuaj. Txawm li cas los xij, yog cov tsos mob pheej mob siab los yog kev txom nyem, nws yog ib qho tseem ceeb kom tham nrog tus kws kho mob.
2. Mob taub hau yog lwm sab kev phiv. Qee tus neeg mob yuav tau ntsib kev ua haujlwm ua kom haum, xws li Nasopylitis (mob ntawm lub qhov ntswg thiab caj pas). Cov tsos mob tshwm sim muaj xws li los ntawm kev tsim lossis cov pob tw ntswg, mob caj pas, thiab hnoos. Thaum cov tsos mob no ib txwm tsis mob hnyav, lawv tuaj yeem ua las voos yog tias lawv txuas ntxiv mus.
3. Kev mob siab ntsws (lossis cov ntshav qab tsawg) yog lwm cov txiaj ntsig sab muaj peev xwm, tshwj xeeb tshaj yog thaum siv ua ke nrog lwm cov tshuaj antihisperglycemic. Cov tsos mob ntawm hypoglycemia suav nrog kiv kiv taub hau, tawm hws, tsis meej pem, thiab tsis muaj zog.
4. Qee tus neeg mob noj Trelagliptin kuj tseem tuaj yeem paub cov leeg mob, suav nrog kev mob sib koom tes thiab mob ib ce. Tshaj - {-}}}}}}}}}}}}}}}}}}}}}}} Cov tshuaj txhuam yog nquag siv los kho cov tsos mob no, uas tej zaum yuav sib txawv. Txawm li cas los xij, yog tias qhov mob hnyav lossis cuam tshuam rau koj cov haujlwm ib txwm, koj yuav tsum mus ntsib kws kho mob.
Txog kev nug txog 99trelagliptin hmoov tus nqi, txaus siab rau Xi'an Sonwu, lossis lwm cov lus nug khoom, thov hu rau Xi'an Sonwu ncaj qha.
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