GHK-CU yog dab tsi?
GHK Cu hmoov, lub npe tag nrho yog tooj liab glycyl-histidine-tripeptide, yog ib qho chaw ntawm glycyl histidine tripeptide (GHK) ua ke nrog tooj liab.
GHK-Cu yog ib qho nyuaj ua los ntawm peb cov amino acids thiab tooj liab ion, nrog cov tooj liab ion ua qhov chaw ncig los ntawm peb cov amino acid molecules. tooj liab yog ib qho tseem ceeb micronutrient rau tib neeg noj qab haus huv. Nws muaj cov txiaj ntsig tseem ceeb ntawm kev loj hlob thiab kev ua haujlwm ntawm cov ntshav, lub hauv paus paj hlwb, lub cev tsis muaj zog, plaub hau, tawv nqaij, pob txha, thiab cov kab mob hauv nruab nrog cev xws li lub hlwb, daim siab, thiab lub plawv. Cov kws tshawb fawb tau lees paub tias hauv lub luag haujlwm ntawm daim tawv nqaij, tooj liab tuaj yeem ua lub luag haujlwm ntawm kev tiv thaiv oxidation, txhawb collagen hyperplasia, thiab pab kho qhov txhab. Tib neeg lub cev physiological ib feem ntawm tooj liab atoms yog tsuas yog los ntawm cov cab kuj ntawm cov amino acid complex (peptide), uas tso cai rau cov bivalent tooj liab ion tivthaiv nrog biochemical los mus rau hauv lub hlwb thiab ua physiological functions. Lub complex yog GHK-Cu. GHK-Cu, Ameslikas cais los ntawm tib neeg plasma thiab tseem pom nyob rau hauv qaub ncaug thiab zis, yog ib qho tshwm sim me me-molecule tooj liab-peptide complex. Cov qib ntawm GHK-Cu hauv ntshav yog kwv yees li 200 ng / ml thaum muaj hnub nyoog 20 xyoo, thiab qib poob mus rau 80 ng / ml ntawm 60. Raws li kev tshawb fawb, GHK-Cu ntseeg tau los txhawb kev kho qhov txhab, nyiam lub cev tiv thaiv kab mob, muaj cov tshuaj tua kab mob antioxidant thiab tiv thaiv kab mob, txhawb nqa collagen thiab glycosaminoglycan synthesis hauv daim tawv nqaij fibroblasts, thiab txhawb cov hlab ntsha. Kev tshawb fawb tsis ntev los no tau pom tias nws tuaj yeem tswj hwm qhov kev qhia ntawm ntau tus neeg cov noob, feem ntau thim rov qab cov noob qhia mus rau lub xeev noj qab haus huv. Yog li ntawd, nyob rau hauv lub lag luam tam sim no, GHK-Cu yog tsuas yog siv nyob rau hauv lub cosmetic kev lag luam thiab yog nrov heev raws li ib tug kho thiab anti-aging khoom.
Cov teebmeem & Cov txiaj ntsig ntawm GHK Cu
GHK Cu hmoov muaj ntau yam txiaj ntsig rau tib neeg lub cev, lub npe nrov tshaj plaws yog nws siv rau tib neeg cov tawv nqaij. Nws tuaj yeem txhawb kev tsim cov collagen, ua kom cov hlab ntsha loj hlob tuaj thiab muaj peev xwm antioxidant, thiab txhawb kev tsim cov glucosaminoglycans los pab cov tawv nqaij rov qab los kho nws tus kheej. Tom qab ntawd, nws tuaj yeem txhawb kev loj hlob thiab sib txawv ntawm cov hlwb epithelial, yog li ua kom lub qhov txhab zoo. Tsis tas li ntawd, nws tseem tuaj yeem txhawb kev loj hlob ntawm cov hauv paus plaub hau, nce qhov loj ntawm cov hauv paus plaub hau, thiab txhawb cov plaub hau kev loj hlob. Cov ntsiab lus yog raws li nram no:
1) Txhim kho daim tawv nqaij antioxidant muaj peev xwm
Rau daim tawv nqaij, "tooj liab" nqa los ntawm GHK-Cu yog ib qho tseem ceeb ntawm cov tshuaj tiv thaiv enzymatic nyob rau hauv basal txheej ntawm daim tawv nqaij. GHK-Cu muaj cov khoom tseem ceeb antioxidant thiab dawb radical scavenging muaj peev xwm, tiv thaiv cov tawv nqaij hlwb, collagen, thiab elastin los ntawm peroxidative puas. Cov kev tshawb fawb tau pom tias GHK-Cu tuaj yeem ua ke nrog O3 hauv cov ntshav thiab cov kua nruab nrog cev thiab cuam tshuam rau O3-induced lipid peroxidation.
Yog li ntawd, siv "tooj liab" los tiv thaiv daim tawv nqaij los ntawm kev puas tsuaj yog ib qho tseem ceeb ntawm kev tshawb fawb tshuaj pleev ib ce niaj hnub, ib yam li qee cov hlau raug tiv thaiv los ntawm "tooj liab plating." Thaum siv cov khoom tu tawv nqaij uas muaj GHK-Cu, GHK-Cu nqa tooj liab ions rau hauv daim tawv nqaij. Cov enzymes tso tawm cov active tooj liab ions tom qab ntsib ntau yam enzymes lom hauv daim tawv nqaij. Thaum cov tooj liab ions ua ke nrog dawb radical O3, cov dawb radicals yog quenched, yog li tiv thaiv daim tawv nqaij los ntawm oxidative puas.
Raws li lub load-nqa peptide, kev tiv thaiv mechanism ntawm GHK-Cu ntawm daim tawv nqaij tseem tsis tau to taub tag nrho. Txawm li cas los xij, nws yog qhov tseeb tias, ntxiv rau kev ua haujlwm antioxidant ntawm xiav tooj liab peptide, GHK-Cu koom nrog thiab koom nrog hauv kev sib txuas ntawm qee cov enzymes tseem ceeb los tswj cov tawv nqaij noj qab haus huv, xws li muaj zog antioxidant - superoxide dismutase SOD, elastin, thiab collagen cross-linking tseem ceeb enzyme - lysyl oxidase. Yog li ntawd, xiav tooj liab peptide tuaj yeem tiv thaiv daim tawv nqaij los ntawm oxidation, yog li tswj xyuas cov tawv nqaij hluas.
2) Txhawb nqa daim tawv nqaij loj hlob, sib txawv, thiab kho
Kev kho mob thiab kev tsim kho ntawm daim tawv nqaij muaj xws li cov lus teb los tiv thaiv kab mob, kev loj hlob ntawm tes, kev hloov pauv ntawm tes, kev hloov kho matrix, thiab lwm yam. Cov lus teb inflammatory ntau dhau tuaj yeem ncua qhov txhab kho thiab ua rau caws pliav. Hauv tib neeg cov hniav fibroblasts, tooj liab peptide complexes GGH, GHK, thiab lwm yam, tuaj yeem txo qhov tso tawm ntawm IL-6 induced los ntawm TNF-alpha. Txawm li cas los xij, lwm qhov chaw tooj liab tsis muaj txiaj ntsig zoo li no. Cov kws tshawb fawb tau xaus lus tias GHK thiab GHK-Cu tuaj yeem siv los ua cov tshuaj tiv thaiv kab mob tsis yog glucocorticoids.
Rau GHK-Cu, qhov tseem ceeb tshaj plaws yog tias GHK tsim cov txheej txheem nrog Cu ions, uas yog qhov tseem ceeb heev vim tias ntau cov enzymes hauv tib neeg lub cev thiab tawv nqaij yuav tsum tau Cu ions. Cov enzymes no koom nrog hauv kev tsim cov ntaub so ntswg, tiv thaiv antioxidant, thiab kev ua haujlwm ntawm tes hauv kev ua pa. Cu ions kuj tseem ua lub cim qhia, uas tuaj yeem cuam tshuam rau tus cwj pwm thiab cov metabolism hauv hlwb. Tsis tas li ntawd, GHK tuaj yeem ua raws li cov cell adhesion molecule, uas tuaj yeem pab cov hlwb ua raws li cov kab mob extracellular matrix, thiab pab cov cell tsiv teb tsaws, proliferate, sib txawv, thiab kho cov tawv nqaij.
3) Txhawb kev tsim kho ntawm daim tawv nqaij qia hlwb
Regeneration ntawm daim tawv nqaij nyob ntawm seb muaj kev vam meej thiab loj hlob ntawm daim tawv nqaij qia hlwb. Cov tawv nqaij hyperplasia pib ntawm lub hauv paus nrog keratinocytes txuas rau hauv qab daus daim nyias nyias. Terminal sib txawv pib thaum cov cell tawm hauv qab daus daim nyias nyias. Stem cells muaj lub peev xwm tsis muaj kev txwv rau kev rov ua dua nws tus kheej, tab sis lawv cov peev txheej loj hlob zuj zus nrog lub hnub nyoog. Thiab GHK-Cu tuaj yeem pab txhawb kev tsim kho ntawm daim tawv nqaij qia hlwb.
4) Txhawb kev kho cov DNA puas
Fibroblasts yog cov hlwb tseem ceeb hauv kev kho qhov txhab thiab kho cov ntaub so ntswg. Lawv synthesize ntau yam ntawm cov extracellular matrix thiab tsim ntau yam kev loj hlob (cov yam ntxwv no tswj cell migration thiab proliferation, angiogenesis, epithelialization, thiab lwm yam). Cov hluav taws xob puas tsuaj rau DNA ntawm cov hlwb, uas ua rau lub cev tsis muaj zog.
Cov kws tshawb fawb tau siv fibroblasts los ntawm caj dab raug hluav taws xob thiab ntxiv GHK rau qhov nruab nrab tsis muaj ntshav, thaum pab pawg tswj tsis tau ntxiv GHK. Txawm hais tias cov hlwb hauv pawg tswj tau tuaj yeem muaj sia nyob thiab rov tsim dua tshiab, lawv txoj kev loj hlob nkhaus tau txawv ntawm cov hlwb li qub. Kev loj hlob ntawm cov hlwb irradiated tau ncua sijhawm piv nrog cov hlwb li qub hauv 24h thiab 48h kev soj ntsuam. Hauv qhov sib piv, irradiated hlwb kho nrog GHK loj hlob sai dua (coj zoo ib yam li cov hlwb ib txwm). Tsis tas li ntawd, GHK-kho cov hlwb ua rau muaj kev loj hlob tseem ceeb dua rau kev kho qhov txhab.
Txij li GHK tuaj yeem rov ua haujlwm ntawm cov hlwb irradiated, nws tsim nyog ntseeg tias GHK tuaj yeem kho DNA puas.
Raws li tus kws tshaj lij GHK-Cu hmoov chaw tsim khoom, Xi'an Sonwu tuaj yeem muab cov hmoov zoo ntawm tus nqi sib tw. Yog tias koj xav tau, tsis txhob yig tiv tauj Xi'an Sonwu.
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