Puas cov hauv paus plaub hau kuj muaj "dormant hloov"? Nrog rau kev loj hlob sai ntawm biotechnology, ib qho tsis paub peptide hu ua PTD-DBM tau txais kev saib xyuas thoob plaws hauv zej zog cov tshuaj kho dua tshiab. Nws tsis yog tsuas yog xav tias yuav muaj peev xwm "tsis yog-hormonal" kev xaiv rau kev tawm tsam cov plaub hau, tab sis kuj yog ib txoj hauv kev kom nkag siab tias qhov kev sim no, kev txiav- ntug thev naus laus zis yuav hloov peb txoj kev nkag siab ntawm kev kho plaub hau li cas. Cia peb nthuav tawm nws cov lus tsis meej ua ke.
PTD yog dab tsi -DBM
PTD-DBM hmoov, luv luv rau Protein Transduction Domain Fusion Disheveled Binding Motif, yog ib qho kev tsim peptide tam sim no nyob rau hauv kev tshawb nrhiav rau nws lub peev xwm los txhawb cov plaub hau kev loj hlob thiab txhawb cov plaub hau follicle regeneration. Cov kws tshawb fawb tshwj xeeb hauv PTD-DBM vim tias nws tuaj yeem cuam tshuam rau Wnt/ -catenin signaling pathway, ib txoj hauv kev lom neeg tseem ceeb koom nrog hauv kev tsim cov hauv paus plaub hau, qia cell ua haujlwm, thiab lub voj voog loj hlob ntawm cov plaub hau. Lub peptide cov txheej txheem ntawm kev ua haujlwm cuam tshuam nrog kev cuam tshuam ntawm CXXC5 thiab Disheveled (Dvl), kev sib cuam tshuam xav kom inhibit Wnt signaling. Los ntawm inhibiting qhov kev cuam tshuam no, PTD-DBM tuaj yeem pab rov ua cov hauv paus plaub hau dormant thiab txhawb cov plaub hau tshiab. Cov kev tshawb fawb preclinical, tshwj xeeb tshaj yog nyob rau hauv cov qauv tsiaj, tau pom nws cov txiaj ntsig zoo hauv kev txhawb cov plaub hau rov tsim dua tshiab thiab txhim kho cov plaub hau follicle. Tam sim no, feem ntau cov formulation ntawm cov tshuaj no yog cov tshuaj pleev ib ce los yog cov plaub hau, qee zaum siv ua ke nrog cov tebchaw xws li methyl vanillin lossis valproic acid los txhim kho nws cov bioactivity. Vim nws cov peptide-raws li cov txheej txheem ntawm kev ua, PTD{11}}DBM tau txais txiaj ntsig zoo hauv kev tshawb fawb kom zoo nkauj, tshuaj kho dua tshiab, thiab kev tshawb fawb kho plaub hau. Tam sim no, PTD-DBM tseem suav tias yog ib qho kev sim lossis kev tshawb fawb. Tseem, raws li kev txaus siab ntawm peptide-raws li kev siv thev naus laus zis txuas ntxiv mus ntxiv, nws tau dhau los ua ib qho tseem ceeb hauv kev tshawb fawb txog plaub hau, tshwj xeeb tshaj yog rau cov kws tshawb fawb tshawb nrhiav tom ntej - tiam mus kom ze rau tawv taub hau thiab cov hauv paus plaub hau kev noj qab haus huv. Yog tias koj txaus siab rau PTD-DBM, thov hu rau Xi'an Sonwu.
Dab tsi yog qhov sib xyaw ntawm PTD-DBM thiab valproic acid?
PTD-DBM thiab valproic acid yog ib qho kev sim cov plaub hau kev loj hlob ua ke uas ua ke nrog peptide PTD-DBM (ib qho protein hloov pauv lub npe-disheveled binding motif) nrog valproic acid (ib txwm siv los tiv thaiv- mob vwm thiab mus ob peb vas stabilizer). Hauv kev tshawb fawb plaub hau, ob yam no tau kawm ua ke vim tias lawv tuaj yeem muaj kev sib koom ua ke, txhawb txoj hauv kev cuam tshuam nrog cov plaub hau follicle regeneration thiab loj hlob.
Mechanism of Action of the Combination Therapy: Ob leeg PTD-DBM thiab valproic acid qhib Wnt/ -catenin signaling pathway, uas ua lub luag haujlwm tseem ceeb hauv cov txheej txheem xws li kev tsim cov hauv paus plaub hau, qia cell ua haujlwm, cov hauv paus plaub hau nkag mus rau theem anagen (loj hlob), thiab kev tsim cov plaub hau.
PTD-DBM lub hom phiaj los thaiv kev cuam tshuam ntawm CXXC5 thiab Disheveled (Dvl), yog li tshem tawm cov teeb liab inhibitory uas inhibits Wnt kev ua haujlwm. Lub caij no, valproic acid ntseeg tau txhim kho Wnt / -catenin signaling los ntawm inhibiting histone deacetylase (HDAC), muaj peev xwm txhawb cov plaub hau follicle activation thiab cell regeneration. This combination is being investigated as a next-generation compound supporting benefits such as increased hair density, follicle stimulation, scalp regeneration, and maintenance of the hair growth cycle.
Cov kev tshawb fawb tsiaj thiab cov chaw kuaj mob tau pom tias muaj txiaj ntsig zoo, nrog qee qhov kev sim qhia tau hais tias kev sib xyaw ua ke ua kom cov plaub hau rov tsim dua tshiab thiab txhim kho cov plaub hau follicle piv rau kev tswj tsis tau kho. Tam sim no, kev txaus siab rau qhov kev sib xyaw ua ke no feem ntau yog los ntawm cov tshuaj kho dua tshiab thiab kev tshawb fawb peptide kom zoo nkauj, tsis yog kev kho mob tseem ceeb hauv kev kho mob dermatology.
Dab tsi yog cov txiaj ntsig ntawm PTD-DBM peptide therapy?
PTD-DBM peptide therapy yog ib qho kev sim peptide therapy tam sim no feem ntau kawm rau kev kho plaub hau thiab follicle regeneration. Cov peptide no yog lub hom phiaj los qhib Wnt/ -catenin signaling pathway, uas ua lub luag haujlwm tseem ceeb hauv kev loj hlob ntawm cov plaub hau follicle thiab qia cell activation.
Cov txiaj ntsig muaj peev xwm ntawm PTD-DBM:
1. Txhawb cov plaub hau rov tsim dua tshiab
Qhov txiaj ntsig tseem ceeb tam sim no tau kawm yog qhov kev txhawb nqa ntawm cov plaub hau tshiab, tshwj xeeb tshaj yog nyob rau hauv androgenetic alopecia (txiv neej / poj niam qauv baldness). Cov kev tshawb fawb tsiaj tau pom tias muaj cov plaub hau ntau ntxiv thiab ntev anagen theem hauv cov hauv paus plaub hau.
2. Ua kom cov hauv paus plaub hau dormant
Cov tshuaj no tuaj yeem pab cov hauv paus plaub hau rov qab los ntawm telogen (regression) theem mus rau anagen (loj hlob) theem. Qhov no yog qhov tseem ceeb vim tias cov plaub hau nyias feem ntau cuam tshuam nrog cov hauv paus plaub hau "stagnating" hauv lub xeev dormant.
3. Ua kom Wnt/ -catenin signaling pathway
Cov peptide no thaiv CXXC5-Dvl kev sib cuam tshuam, yog li tso lub ntuj "brake" ntawm Wnt signaling. Txoj hauv kev no yog qhov tseem ceeb rau cov txheej txheem hauv qab no: kev ua kom cov plaub hau follicle qia cell, cov plaub hau follicle regeneration, dermal papilla cell proliferation, thiab cov plaub hau ncej.
4. Muaj peev xwm ua kom cov plaub hau tuab
Cov kev tshawb fawb preclinical qhia tias cov tshuaj no tuaj yeem txhim kho cov plaub hau follicle loj thiab cov plaub hau txoj kab uas hla, yog li ua rau cov plaub hau tuab.
5. Tsis yog-Hormonal Hair Loss Treatment
Tsis zoo li cov kev kho mob xws li finasteride, nws feem ntau ua rau txoj kev rov tsim dua tshiab, tsis yog dihydrotestosterone (DHT) lossis lwm yam tshuaj hormones. Qhov no distinguishes nws mechanism ntawm kev txiav txim los ntawm tus qauv plaub hau tsis tshuaj.
6. Muaj peev xwm kho qhov mob thiab rov tsim dua tshiab
Qee qhov kev tshawb fawb thaum ntxov qhia tias nws tuaj yeem txhawb qhov txhab -induced plaub hau follicle regeneration thiab cov ntaub so ntswg regeneration los ntawm activating Wnt signaling txoj kev.
Tam sim no, feem ntau PTD-DBM kev tshawb fawb tsom mus rau kev tshawb fawb nas, kev tshawb fawb kab lis kev cai ntawm tes, thiab kev sim tib neeg cov plaub hau follicle organoculture. Cov kws tshawb fawb tab tom tshawb xyuas cov ntawv thov ntawm PTD-DBM hauv cov txiv neej qauv baldness, plaub hau follicle regeneration, plaub hau qia cell ua kom, thiab kev kho mob ua ke nrog microneedling lossis lwm yam stimulants loj hlob. Yog li ntawd, nws yog ib qho kev tshawb nrhiav peptide.
Rau cov ntsiab lus ntawm tus nqi ntawm PTD-DBM hmoov lossis cov ntaub ntawv khoom ntxiv, thov hu ncaj qha rau Xi'an Sonwu.
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Siv: https://www.peptidesinstitute.org/peptides/ptd-dbm?utm_source=chatgpt.com