Ordinary penicillin feem ntau tsis muaj txiaj ntsig tiv thaiv kab mob ntse uas tsim "degrading enzymes." Yog li, cov kws tshawb fawb tau hloov kho cov tshuaj li cas los hloov oxacillin mus rau hauv lub zog nemesis tiv thaiv cov tshuaj tiv thaiv Staphylococcus aureus? Cov tshuaj tua kab mob no yog dab tsi, uas tuaj yeem ua tiav lub hom phiaj ntawm cov kab mob phab ntsa thiab tsis yooj yim tawg los ntawm cov kab mob, ua si hauv peb lub cev?
Cov tshuaj tua kab mob oxacillin yog dab tsi
Oxacillin hmoovyog -lactam tshuaj tua kab mob, nyob rau hauv cov chav kawm penicillin. Tshwj xeeb, nws yog penicillinase- tiv taus penicillin, lossis tshuaj tiv thaiv -staphylococcal penicillin. Nws tau tsim los tawm tsam cov kab mob uas tsim penicillinase, ib qho enzyme uas zom cov tshuaj tua kab mob penicillin, txo lawv cov txiaj ntsig. Oxacillin feem ntau yog siv los kho Gram- cov kab mob zoo, tshwj xeeb tshaj yog tshwm sim los ntawm methicillin-sensitive Staphylococcus aureus (MSSA). Kev siv tshuaj kho mob feem ntau suav nrog cov kab mob ntawm daim tawv nqaij thiab cov nqaij mos, osteomyelitis, mob ntsws, endocarditis, thiab cov kab mob hauv cov hlab ntsha los ntawm cov kab mob staphylococci. Vim nws tsis kam mus rau cov kab mob penicillinase, oxacillin tseem yog ib qho tseem ceeb rau kev kho cov kab mob staphylococcal. Cov tshuaj tua kab mob ntsig txog hauv tib chav kawm ntawm cov tshuaj tiv thaiv -staphylococcal penicillins suav nrog nafcillin, dicloxacillin, thiab cloxacillin. Yog tias koj xav tau oxacillin, thov hu rau Xi'an Sonwu.
oxacillin cuam tshuam li cas rau cov kab mob
Oxacillin, ib hom kab mob bactericidal -lactam tshuaj tua kab mob, inhibits kab mob cell phab ntsa synthesis. Nws ncaj qha tua cov kab mob uas raug mob, es tsis yog tsuas yog ua rau lawv txoj kev loj hlob qeeb. Nws cov txheej txheem ntawm kev ua haujlwm feem ntau cuam tshuam nrog cov kab mob tshwj xeeb enzymes hu ua penicillin-binding proteins (PBPs), uas ua lub luag haujlwm tseem ceeb hauv cov theem kawg ntawm cov kab mob ntawm phab ntsa tsim. Cov proteins no catalyze tus ntoo khaub lig-txuas ntawm peptidoglycan chains, ib qho tseem ceeb hauv lub network uas muab lub zog, rigidity, thiab kev tiv thaiv rau lub phab ntsa ntawm cov kab mob. Los ntawm kev khi rau thiab thaiv cov PBPs, qhov sib xyaw ua ke cuam tshuam nrog kev sib sau ua ke thiab kho cov kab mob ntawm cov phab ntsa, tiv thaiv cov kab mob los ntawm kev tswj cov txheej txheem kev ncaj ncees thaum lub sij hawm loj hlob thiab kev faib tawm. Raws li qhov tshwm sim, phab ntsa ntawm tes tsis tuaj yeem tiv taus osmotic siab, thaum kawg ua rau cov kab mob ntawm tes tawg, lysis, thiab tuag.
Cov tshuaj no muaj nyob rau hauv cov tshuaj tiv thaiv -penicillinase penicillin chav kawm, ib chav kawm ntawm cov tshuaj tua kab mob tshwj xeeb tsim los tiv thaiv kab mob rau penicillinases ( -lactamases). Ntau hom Staphylococcus tsim cov enzymes no, uas ua kom cov tshuaj tua kab mob penicillin sai sai los ntawm kev rhuav tshem ntawm -lactam ring-ib qho tseem ceeb ntawm cov tshuaj tua kab mob penicillin. Cov qauv tshuaj ntawm cov tshuaj no tau hloov kho los tiv thaiv kev degradation los ntawm cov enzymes, yog li tswj nws cov haujlwm tiv thaiv ntau yam penicillinase- tsim cov kab mob Gram- zoo, tshwj xeeb tshaj yog methicillin-sensitive Staphylococcus aureus (MSSA). Vim nws txoj kev ruaj ntseg, qhov sib xyaw no tau siv los kho cov kab mob MSSA hnyav rau ntawm daim tawv nqaij, cov nqaij mos, pob txha, pob qij txha, lub plawv li qub, thiab cov ntshav.
Ntxiv nrog rau nws cov txiaj ntsig tiv thaiv MSSA, cov tshuaj no kuj tseem tuaj yeem tiv thaiv qee yam kab mob Gram -cov kab mob zoo, suav nrog qee tus Streptococcus spp. Txawm li cas los xij, nws cov kab mob tua kab mob yog nqaim dua li ntawm qee qhov dav -spectrum -lactam tshuaj tua kab mob, thiab nws tsis muaj txiaj ntsig rau feem ntau Gram- cov kab mob tsis zoo. Nws yuav tsum yog feem ntau tsis muaj txiaj ntsig tiv thaiv methicillin-resistant Staphylococcus aureus (MRSA). MRSA hom kab mob txhim kho los ntawm kev tsim cov tshuaj penicillin hloov pauv -binding proteins (PBPs), tshwj xeeb tshaj yog PBP2a. PBP2a muaj qhov txo qis kev sib raug zoo rau -lactam tshuaj tua kab mob. Txawm hais tias cov tshuaj tiv thaiv tsis zoo rau -lactamase kev puas tsuaj, nws tsis tuaj yeem khi rau cov protein hloov pauv no, cia cov kab mob MRSA txuas ntxiv ua cov phab ntsa ntawm tes txawm tias muaj cov tshuaj.
Yog oxacillin zoo ib yam li penicillin
Yog-oxacillin zoo ib yam li penicillin, tab sis oxacillin muaj txiaj ntsig zoo hauv kev tawm tsam qee yam kab mob. Cias muab tso, koj tuaj yeem xav txog penicillin yog thawj cov tshuaj tua kab mob, thaum oxacillin yog ib qho kev txhawb zog tshwj xeeb uas tsim los tawm tsam cov kab mob uas "kawm ua kom puas penicillin."
Penicillin thiab oxacillin yog tib cov tshuaj tua kab mob: -lactam tshuaj tua kab mob. Lawv cov txheej txheem ntawm kev ua haujlwm yog qhov tseem ceeb tib yam -los ntawm kev khi rau penicillin-binding proteins (PBPs), lawv thaiv cov kab mob cell phab ntsa synthesis, thaum kawg tua cov kab mob.
Qhov tseem ceeb sib xws:
Tib lub tswv yim ntawm kev ua (inhibition ntawm cov kab mob ntawm phab ntsa ntawm tes)
Tib core -lactam nplhaib qauv
Ob leeg muaj cov kab mob bactericidal (lawv tua cov kab mob, tsis yog inhibit lawv txoj kev loj hlob)
Qhov sib txawv tseem ceeb:
Ordinary penicillin tau yooj yim tawg los ntawm penicillinases ( -lactamases) tsim los ntawm qee cov kab mob.
Oxacillin yog penicillinase- tiv taus penicillin, txhais tau tias nws tau raug hloov kho los tiv thaiv penicillinases uas tsim los ntawm cov kab mob xws li Staphylococcus aureus (MSSA).
Dab tsi yog Cov Kev Mob Feem Ntau Ntawm Oxacillin
Oxacillin tuaj yeem ua rau muaj ntau yam kev mob tshwm sim, feem ntau yog me me mus rau nruab nrab, zoo ib yam li lwm cov tshuaj tua kab mob penicillin. Feem ntau tshaj tawm cov kev mob tshwm sim muaj xws li lub plab zom mov, tawv nqaij, lossis qhov chaw txhaj tshuaj.
Cov kev mob tshwm sim feem ntau ntawm cov tshuaj no:
Ntshai
ntuav
Mob plab
Mob plab
Raj
Kev tsis haum tshuaj me me
Qhov chaw txhaj tshuaj mob lossis khaus khaus
Transient nce siab ntawm daim siab enzymes
Qee tus neeg mob kuj tuaj yeem mob taub hau, qaug zog, lossis kub taub hau thaum kho.
Vim hais tias oxacillin yog penicillin, cov neeg mob uas muaj keeb kwm ntawm kev ua xua rau penicillin tej zaum yuav muaj kev pheej hmoo siab ntawm kev tsis haum tshuaj. Yog tias koj muaj pob khaus hnyav, ua tsis taus pa, mob raws plab, lossis cov tsos mob ntawm daim siab mob thaum kho, nws raug nquahu kom nrhiav kev kho mob.
Rau cov ntsiab lus ntawm tus nqi ntawm oxacillin hmoov lossis cov ntaub ntawv khoom ntxiv, thov hu ncaj qha rau Xi'an Sonwu.
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Cov ntaub ntawv: https://egnlab.com/en/medications/marbofloxacin