Cov tshuaj Triclabendazole
Veterinary triclabendazole hmoovyog ib qho ntawm cov khoom uas muaj cov teebmeem zoo heev ntawm fasciola flukes thiab disc flukes hauv nyuj thiab yaj. Nws yog ib qho tshuaj zoo tshaj plaws los tua fasciola hepatica. Fasciola yog ib hom kab mob cab. Feem ntau hais lus, kab mob muaj xws li nematodes, tapeworms, trematodes, schistosomiasis, coccidia, Trypanosoma, muab, trichomonas, thiab lwm yam, thiab cov tshuaj tua kab siv rau txhua hom kuj txawv. Thaum siv cov tshuaj, nws yog ib qho tsim nyog yuav tau noj cov tshuaj sib hloov, tshuaj tua kab mob, thiab cov tshuaj sib xyaw ua ke raws li lwm yam kab mob parasites. Cov ntshiab triclabendazole tuaj yeem siv ua ke nrog levamisole thiab methotrexate.
Yuav ua li cas yog lub mechanism ntawm kev txiav txim ntawm triclabendazole
Cov tshuaj tua kab mob ntawm triclabendazole tawm tsam trematodes tseem tsis tau paub meej, thiab nws cov metabolites, sulfoxide thiab sulfone, suav tias yog cov khoom tseem ceeb. Nws cov tshuaj tua kab yog nqaim thiab tsuas yog pom tias muaj cov tshuaj tua kab mob rau cov neeg laus thiab cov larvae ntawm Fasciola hepatica thiab Paragonimus. Nws tsis muaj txiaj ntsig tiv thaiv Clonorchis Sinensis. Tam sim no muaj ob qho kev piav qhia rau cov kab mob tua kab mob ntawm triclabendazole tawm tsam trematodes:
Ua ntej, nws ua haujlwm tsuas yog los ntawm kev cuam tshuam thiab inhibiting cov qauv thiab kev ua haujlwm ntawm microtubules hauv cov cab. Cov txiaj ntsig kev sim ntawm triclabendazole tawm tsam Fasciola hepatica pom tias cov tshuaj muaj cov nyhuv inhibiting colchicine. Cov nyhuv no txhais tau hais tias tubulin raug khi, thiab tso tawm cov kab mob parasite proteolytic enzymes yog inhibited.
Qhov thib ob, cov tshuaj cov txheej txheem ntawm kev ua haujlwm yog inhibit protein synthesis hauv cov cab. Kev sim tau pom tias chromatin nyob rau hauv lub nucleus ntawm Fasciola hepatica hlwb yog condensed, lub nucleolus ploj, RNA synthesis txo, thiab ribosome txo. Qhov txiaj ntsig no tau qhia tias qhov sib txawv ntawm cov neeg laus thawj cov kab mob spermatogonia yog inhibited, yog li tiv thaiv kev tsim ntawm spermatocytes thiab spermatozoa. Cov txheej txheem saum toj no yog kev ywj pheej thiab sib cuam tshuam. Cov tshuaj no feem ntau ua rau microtubules nyob rau theem pib thiab feem ntau inhibit protein synthesis nyob rau theem tom ntej.
Kuj tseem muaj qee qhov kev sim tau pom tias triclabendazole kuj tseem tuaj yeem cuam tshuam cov metabolism ntawm nucleic acids. Triclabendazole tau siv nyob rau hauv vivo thiab hauv vitro insecticidal thwmsim rau cov dev hauv tsev uas kis tus kab mob Paragonimus westermani. Cov kab mob 'protein thiab DNA cov ntsiab lus poob qis dua piv rau pawg tswj hwm. Qhov txiaj ntsig no ua pov thawj tias triclabendazole feem ntau inhibits thiab rhuav tshem cov protein synthesis thiab metabolism ntawm Paragonimus. Ntxiv mus, qhov kev sim kuj pom tau tias triclabendazole muaj qhov cuam tshuam zoo rau lub cev phab ntsa ntawm Paragonimus wetermani thiab ultrastructure ntawm yolk cells. Kev soj ntsuam thiab xa cov tshuab hluav taws xob ntsuas hluav taws xob soj ntsuam ntawm Paragonimus parasites tua los ntawm triclabendazole hauv vivo thiab hauv vitro hauv cov dev uas cov tshuaj ua rau kev ploj ntawm Golgi lub cev hauv cortical thiab yolk hlwb ntawm cov kab mob, nthuav tawm, thiab deterioration ntawm endoplasmic reticulum, denaturation ntawm mitochondria, thiab cell. daim nyias nyias. Tag nrho cov no txhawb cov lus piav qhia tias cov tshuaj ua rau lub microtubule system thiab cov txheej txheem membrane. Txawm hais tias hauv vivo lossis hauv vitro, triclabendazole tsis muaj qhov cuam tshuam loj rau glycogen granules hauv cov kab mob cab.
Kev siv Triclabendazole
Triclabendazole tau siv ntawm ib koob ntawm 50 mg / kg ib hnub rau ob hnub sib law liag los kho ob sab Paragonimus uteri kab mob hauv paj rwb nas, thiab cov tshuaj tua kab nce mus txog 100 feem pua. Siv triclabendazole ntawm 10 mg / kg ib hnub rau ob hnub sib law liag los kho tus kab mob Paragonimus westermani hauv cov dev hauv tsev, qhov nruab nrab ntawm cov tshuaj tua kab yog 98.5 feem pua, thiab muaj qhov poob qis hauv cov kab mob uas muaj sia nyob. Qhov hnyav poob qis, qhia tau tias Cov tshuaj muaj tshuaj lom zoo heev ntawm Paragonimus wetermani. Piv nrog rau pawg tswj hwm, cov kab hlwv cov kab mob hauv lub ntsws ntawm pab pawg kho mob thiab qhov loj ntawm cov kab hlwv shrunk thiab hardened; nws yog xim dub, uas yog tshwm sim los ntawm kev tuag thiab decomposition ntawm cov cab thiab maj mam nqus los ntawm lub cev. Raws li lub sij hawm mus tom qab kev kho mob, cov hlwv txuas ntxiv zuj zus los yog ploj mus.
Tsis tas li ntawd, ntau lub qe tuag tuaj yeem pom ntawm cov kab mob pathological ntawm kab cyst. Triclabendazole tau siv los kho cov nas uas muaj kab mob U. stienzii, tag nrho cov koob tshuaj yog 300 mg / kg (2 hnub), 450 mg / kg (3 hnub), thiab 600 mg kg (3 hnub), tus nqi tua ntawm cov larvae yog 50. feem pua, 80 feem pua, thiab 87 feem pua. Triclabendazole tau siv ntawm ib koob ntawm 8 mg / kg ib hnub los tua cov kab mob ntawm Paragonimus westermani hauv cov nas rau ob hnub sib law liag, thiab qhov txo qis yog 38.3 feem pua.
Kev siv tshuaj Triclabendazole
Raw triclabendazole tau siv dav hauv cov tebchaws thoob plaws ntiaj teb thiab muaj txiaj ntsig zoo rau cov ruminants xws li nyuj, yaj, thiab tshis. Yaj: Ib koob tshuaj triclabendazole qis (txawm tias qis li 2.5 mg / kg) muaj qhov ua tau zoo ntawm 98 feem pua rau 100 feem pua rau 12-cov neeg laus hnub nyoog yaj, 5 mg / kg rau 10-lub lim tiam - laus laus, thiab 10 mg/kg rau yaj Rau 6-8 lub lim tiam muaj hnub nyoog worm lub cev, 12.5 mg/kg yog rau 1-4 lub lis piam hnub nyoog tsis paub qab hau worm lub cev, 15 mg / kg yog ze li ntawm 100 feem pua rau 1 hnub hnub nyoog worm lub cev zoo npaum li cas.
Nyuj: Cov nyhuv ntawm triclabendazole rau kev tshem tawm Fasciola hepatica ntawm cov tsiaj nyeg zoo ib yam li cov yaj. Qhov txiaj ntsig zoo ntawm 6 mg / kg yog 95 feem pua ~ 99.5 feem pua rau 8-14 cov neeg laus hnub nyoog ib asthiv; 12 mg/kg yog 79 feem pua thiab 87 feem pua , raws li, rau 2-lub lim tiam, 4-lub lim tiam, thiab 8- cov neeg laus hnub nyoog, 99.4 feem pua. Cov nyhuv ntawm 12 mg / kg rau cov neeg laus cab ntawm Fasciola bovis zoo ib yam li Fasciola hepatica.
Lwm tus: 10 mg / kg rau Fasciola mos lwj daim siab thiab fasciola loj.
12 mg / kg kuj tseem siv tau rau Fasciola nees siab.
Triclabendazole rau muag
Lub toxicity ntawm cov khoom no yog negligible, thiab kev kho mob koob tshuaj tsis muaj lus teb rau cov tsiaj, tab sis nws yog heev toxicity rau ntses.
Cov tshuaj yuav tsum tau rov ua dua ib zaug tom qab tsib lub lis piam los kho tus mob hepatic fascioliasis.
Nws yog txwv tsis pub thaum lub sij hawm pub mis.
Tsis tas li ntawd, txiav txim los ntawm peb lub tuam txhab ntau tshaj kaum xyoo ntawm kev tsim khoom. Feem ntau, triclabendazole feem ntau yog sib xyaw nrog lwm cov tshuaj kho tsiaj. Peb tsis tuaj yeem muab cov triclabendazole nyoos rau koj tab sis kuj tseem muab rau koj lwm cov khoom lag luam kws kho tsiaj. Yog tias koj xav tau triclabendazole lossis muaj lus nug ntxiv txog cov khoom no, nyem rau ntawm email chaw nyob, thiab kuv yuav muab cov lus qhia zoo lossis kev daws teeb meem rau koj qhov teeb meem.
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