Quercetin ntxiv
Organic quercetin hmoovthiab nws cov derivatives yog flavonoids dav faib nyob rau hauv cov nroj tsuag lub nceeg vaj thiab muaj ntau yam kev ua ub no lom. Nws muaj nyob rau hauv ntau cov nroj tsuag paj, nplooj, thiab txiv hmab txiv ntoo, feem ntau nyob rau hauv daim ntawv ntawm glycosides, xws li rutin, quercetin, serine, thiab lwm yam. Quercetin tuaj yeem tau los ntawm acid hydrolysis. Cov ntsiab lus ntawm quercetin hauv dos yog qhov siab tshaj plaws, yog li quercetin tseem hu ua dos. Nws muaj ntau yam khoom siv lom neeg, suav nrog antioxidant thiab dawb radical scavenging, anti-fibrosis, anti-viral, analgesic, thiab tiv thaiv kab mob plawv, uas tsim lub hauv paus rau kev tswj hwm kev noj qab haus huv thiab kab mob.
Dab tsi yog cov khoom lom thiab tshuaj ntsuab ntawm quercetin
1. Quercetin muaj qhov cuam tshuam ncaj qha rau superoxide anion, hydroxyl radical, thiab lipid peroxidation dawb radical.
Kev puas tsuaj dawb radical tuaj yeem ua rau lossis ua rau muaj kab mob hnyav xws li cov hlwb tsis zoo, mob stroke, thiab kab mob plawv thiab cuam tshuam nrog kev laus. Dawb radicals yog tsim nyob rau hauv lub cev txhua lub sijhawm. Thaum qhov sib npaug ntawm oxidation thiab tiv thaiv oxidation tawm ntawm qhov sib npaug, cov hlwb yuav puas vim oxidative kev nyuaj siab, nws thiaj li ua rau cov kab mob.
Flavonoids 'dawb radical scavenging peev xwm yog ib feem ntawm OH pawg ntawm cov tshuaj antioxidant active pab pawg-phenol hauv cov qauv molecular. Quercetin thiab nws cov derivatives, uas yog cov flavonoids, yog superoxide anion radical scavengers. Nws muaj 4 OH pawg ntawm chroman nplhaib ntawm polyphenols thiab 4- txoj hauj lwm thiab 3' ntawm lub nplhaib B. Cov pab pawg hydroxyl ntawm 4 'txoj haujlwm thiab qhov tsis txaus ntseeg ob daim ntawv cog lus ntawm 2.3 txoj haujlwm endow quercetin nrog lub peev xwm antioxidant muaj zog. Cov khoom antioxidant ntawm quercetin tsis yog tsuas yog ua raws li kev ntes cov pa dawb radicals xwb tab sis kuj ua raws li nws lub peev xwm los khi cov hlau hloov pauv nrog redox oxidation los tsim cov hlau chelates, yog li deactivating hloov hlau xws li hlau thiab tooj liab. Quercetin tuaj yeem ua rau cov hlau ions nyuaj los tsim cov hlau tsis muaj zog ion complex, tiv thaiv cov hlau ions los ntawm kev koom nrog cov tshuaj lom neeg ntawm ntau cov dawb radicals, xws li Fenton cov tshuaj tiv thaiv. Nyob rau hauv sib piv, cov hlau ion complex tseem tuav cov kev ua ntawm ib tug dawb radical scavenger. Nyob rau tib lub sijhawm, quercetin tuaj yeem tiv thaiv aldose reductase, thiab txo NADPH noj, yog li txhim kho lub cev muaj peev xwm antioxidant.
2. Quercetin ua raws li cov protein kinase inhibitor thiab modulates protein kinase signaling txoj kev
Ntshiab quercetin yog ib qho protein kinase inhibitor uas muaj nyob rau hauv cov khoom noj uas cog. Nws tuaj yeem sib tw khi rau ATP-binding site ntawm cov protein kinases xws li PI3K, hloov kinase lub xeev phosphorylation, thiab ua rau nws tsis ua haujlwm. Kev sib tw binding muaj peev xwm ntawm quercetin rau cov protein no txiav txim siab nws cov nyhuv inhibitory ntawm cov protein kinases. Quercetin muaj peev xwm tshwj xeeb inhibit CK2, AMPK, PI3K, thiab lwm yam protein kinases, thiab tus nqi inhibition nce mus txog 20 feem pua. Qhov inhibition ntawm quercetin protein kinase tuaj yeem qhia txog kev tiv thaiv kab mob thiab kev tiv thaiv kab mob ntawm cov hlwb, thiab tau kawg, nws yuav yog qhov txawv. 10-30 μM quercetin induces caspase peb activations los ntawm inhibiting Akt thiab ERK phosphorylation, ua rau thawj neuronal cell tuag. Txawm li cas los xij, txawm tias tom qab tib neeg noj cov zaub mov uas muaj quercetin, qhov concentration hauv cov ntshav yog deb ntawm qhov siab tshaj.
3. Quercetin ua raws li lub cim qhia molecule los tswj cov noob qhia
Flavonoids xws li quercetin tsis tuaj yeem hloov pauv cov xwm txheej phosphorylation ntawm lub hom phiaj molecules los ntawm kev xaiv kev cuam tshuam nrog ntau yam ntawm cov protein kinases thiab lipid kinase signaling cascades, inhibit lossis ua kom cov kev taw qhia no cuam tshuam rau kev ua haujlwm ntawm tes, tab sis kuj txhawb nqa cellular endogenous antioxidant tiv thaiv los ntawm kev hloov pauv. gene qhia. Quercetin thiab cov zoo li tswj cov kev qhia ntawm cov noob hauv qab ntawm qhov sib lawv liag los ntawm kev ncaj qha lossis tsis ncaj ntawm cov txheej txheem DNA tshwj xeeb.
Nuclear factor kappa B thiab activator protein-1
NF-KB yog ib qho tseem ceeb ntawm kev hloov pauv ntawm cov ntaub ntawv hauv eukaryotic hlwb. Nws ua lub luag haujlwm tswj hwm hauv kev hloov pauv ntawm cov noob ntsig txog kev tiv thaiv kab mob thiab kab mob, kev loj hlob, kev loj hlob, thiab kev tuag. Nws ua lub luag haujlwm tseem ceeb hauv cov kab mob pathogenesis vim muaj kev koom tes ntawm cytokines, inflammatory mediators, thiab proteases. Txawm li cas los xij, overactivation ntawm NF-KB yog, tib lub sijhawm, yog ib qho ntawm cov laj thawj tseem ceeb ntawm ntau yam kab mob-. Quercetin thiab tshuaj yej ntsuab extract tuaj yeem tswj cov kev ua haujlwm dhau ntawm NF-KB, uas tuaj yeem muaj cov tsos mob-kev txhim kho ntawm cov xwm txheej cuam tshuam los ntawm overactivation ntawm NF-KB. Tsis tas li ntawd, quercetin tuaj yeem tswj tau qhov kev qhia ntawm AP-I. AP-I kev hloov pauv feem ntau tshwm sim hauv cov hlwb hauv daim ntawv ntawm c-Fos / c-Jun heterodimer thiab c-Jun / c-Jun homodimer. Nws ua lub luag haujlwm tseem ceeb hauv kev tswj hwm ntau yam kab mob gene, ua kom muaj cov pab pawg oxidative kev ntxhov siab, thiab tswj cov noob qhia txog kev loj hlob ntawm tes thiab kev ntxhov siab.
Xenobiotic teb cov ntsiab lus
Cov cheeb tsam txhawb nqa ntawm CYP450 enzyme tsev neeg cov noob muaj XRE, uas tuaj yeem tswj hwm ib nrab los ntawm aryl hydrocarbon receptor AhR. Quercetin ua raws li lub ntuj ligand, ncaj qha khi rau AhR, thiab induces transcription ntawm XRE-txog cov noob. Vim tias AhR ua lub luag haujlwm tseem ceeb hauv kev ua haujlwm ntawm CYP450 enzymes, kev noj haus ntawm quercetin tuaj yeem nce qib ntawm cell theem I thiab theem II detoxification enzymes thiab zoo dua tiv thaiv kev puas tsuaj rau lub cev.
4. Quercetin ua raws li topoisomerase inhibitor los tiv thaiv kab mob sib kis
DNA topoisomerases tswj kev saib xyuas ntawm DNA topology. Quercetin yog ib qho muaj zog inhibitor ntawm hom I thiab hom II topoisomerases, thiab nws tuaj yeem sib tw nrog ATP-binding domain ntawm topozyme thiab inhibit DNA unwinding. Raws li txoj cai, quercetin tuaj yeem cuam tshuam tus kab mob sib kis los ntawm kev hloov pauv cov txheej txheem ntawm cov kab mob DNA. Quercetin tuaj yeem cuam tshuam qhov tshwm sim ntawm tib neeg lub cev tiv thaiv kab mob, yog li ua rau muaj kev tiv thaiv HIV.
Tom qab metabolizing quercetin nyob rau hauv lub cev, metabolic kev hloov pauv hloov nws cov antioxidant zog. Txawm hais tias cov metabolites ntawm quercetin (xws li glucuronide, methylated form, thiab quercetin-GSH conjugated daim ntawv) tseem muaj peev xwm txo tau cov hydrogen ions, lawv cov kev ua tau zoo hauv kev tshem tawm cov pa oxygen ntau dua li ntawm lawv niam txiv aglycone. Tsis muaj zog. Tsis tas li ntawd, cov concentrations ntawm quercetin thiab nws cov metabolized cov ntaub ntawv nyob rau hauv cov ntshav thiab cov kabmob yog qis dua cov me me molecule antioxidants xws li vitamin C thiab vitamin E. Qhia tau hais tias cov koob tshuaj quercetin tuaj yeem tsim cov tshuaj lom neeg hauv vitro muaj ntau dua li hauv vivo lub ncov concentration. Txawm li cas los xij, quercetin's hauv vivo tiv thaiv muaj zog dua li cov lus hais saum toj no me me molecule antioxidants.
Yuav ua li cas noj quercetin
Koj tuaj yeem yuav quercetin hmoov lossis tshuaj ntsiav hauv online ntawm Xi'an Sonwu raws li kev noj haus ntxiv. Quercetin muaj nyob rau hauv ntau cov khoom noj uas nquag noj thiab muaj nyob rau hauv kev noj haus ntxiv. Pom zoo ntau npaum li cas ntawm 500–1, 000 mg ib hnub twg. Quercetin muaj tsawg bioavailability, uas txhais tau hais tias koj lub cev absorbs nws tsis zoo. Cov khoom siv yuav suav nrog lwm cov tshuaj xws li vitamin C los yog digestive enzyme bromelain, vim lawv tuaj yeem ua rau kom nqus tau.
Tsis tas li ntawd, quercetin muaj kev sib koom ua ke thaum ua ke nrog lwm cov tshuaj xws li resveratrol, genistein, thiab catechins.
FAQ
Yog tias koj xav tau quercetin nyoos lossis muaj lwm cov lus nug txog cov khoom no, nyem rau ntawm email chaw nyob, Xi'an Sonwu yuav muab cov kev daws teeb meem zoo rau koj qhov teeb meem.
Email:sales@sonwu.com