CMS121 hmoov

CMS yog dab tsi -121

CMS121 hmoov, tseem hu ua 4-[4-(cyclopentyloxy)-2- quinolinyl]-1, 2-benzenediol ntxiv, yog ib qho khoom siv hluavtaws, vim nws cov qauv tshuaj tshwj xeeb thiab muaj peev xwm kho tau Nws tau nyiam ntau yam hauv cov tshuaj thiab biochemistry. daim ntawv thov. Qhov no me me-molecule compound belongs rau chav kawm ntawm quinoline derivatives uas tau pom muaj kev cog lus lom neeg nrog rau kev cuam tshuam rau ntau yam kev mob nkeeg.

Cov mis mos ntawm CMS121 yog C20H19NO2, thiab nws qhov hnyav molecular yog li 313.37 g / mol. Nws cov qauv tshuaj sib xyaw ua ke quinoline core nrog cyclopentyloxy thiab quinone ua haujlwm pab pawg, ua rau nws muaj cov khoom tshwj xeeb thiab muaj peev xwm cuam tshuam nrog cov hom phiaj lom neeg tshwj xeeb.

Ib qho ntawm qhov tseem ceeb ntawm kev txaus siab rau CMS121 yog nws lub peev xwm ua tus neeg sawv cev tiv thaiv kab mob. Kev mob plab yog ib qho tseem ceeb ntawm ntau yam kab mob, nrog rau cov kab mob ntev xws li mob caj dab rheumatoid, kab mob plab hnyuv thiab kab mob neurodegenerative. Los ntawm kev hloov kho cov kev taw qhia tseem ceeb thiab inhibiting zus tau tej cov pro-inflammatory molecules, CMS121 tau pom cov lus cog tseg hauv kev txo qhov mob thiab muaj feem cuam tshuam cov tsos mob.

CMS121 kuj nthuav tawm cov teebmeem neuroprotective, qhia nws lub peev xwm hauv kev tawm tsam cov kab mob neurodegenerative. Nws tiv thaiv cov hlwb neuronal los ntawm oxidative kev nyuaj siab thiab txo cov neuroinflamation, ob yam tseem ceeb hauv neurodegeneration. Cov kev tshawb pom no qhia tias CMS121 muaj peev xwm ua kom qeeb ntawm cov kab mob phem no thiab txhim kho cov txiaj ntsig rau cov tib neeg cuam tshuam.

Tsis tas li ntawd, CMS121 tau pom muaj peev xwm hauv thaj chaw ntawm oncology. Cov kev tshawb fawb preclinical tau pom tias nws muaj cov tshuaj tiv thaiv kab mob qog noj ntshav, inhibiting lawv txoj kev loj hlob thiab muaj peev xwm muab txoj hauv kev tshiab rau kev kho mob qog noj ntshav.

Lub purity ntawm peb lub tuam txhab cms121 ntxiv tuaj yeem ncav cuag 99 feem pua. Tsis tas li, peb cov nqi sib tw heev piv rau lwm lub tuam txhab. Yog tias koj xav paub ntau ntxiv, thov hu rau Xi'an Sonwu Biotech Co. Ltd.

Yuav CMS -121 Online

Xi'an Sonwu muaj kev paub dhau los hauv kev lag luam thoob ntiaj teb thiab kev noj qab haus huv kev lag luam. Reputation-raws li zoo ua ntej yog lub hauv paus ntsiab lus ntawm Xi'an Songwu Company. Xi'an Sonwu nruj me ntsis tswj cov khoom zoo, yog li xaiv cov ntaub ntawv pib nrog raw cov ntaub ntawv. Tsis tas li ntawd, peb tswj txhua qhov kev nthuav dav thiab txo qis tus nqi kom peb cov neeg siv khoom tau txais cov khoom lag luam zoo tshaj plaws. Raws li cov no, cov neeg siv khoom tau txais kev qhuas siab rau peb cov khoom. Yog tias koj xav tau cms121 ntxiv, nrhiav Xi'an Sonwu Biotech Co. Ltd.

Peb ua kom paub tseeb ntawm cov khoom zoo, yog li cov qauv tuaj yeem muab tau. Ntawm no yog qhov ntau.

Cov neeg siv khoom 'Cov lus pom zoo

Kev Pabcuam OEM

Xi'an Sonwu tsis tsuas yog tuaj yeem muab cov khoom zoocm121 uahmoov, tab sis kuj muab nws cov tshuaj ntsiav.

Yog li txhua tus neeg siv khoom tuaj yeem kho cov tshuaj ntsiav lawv xav tau. Thiab cov khoom hauv qab no tuaj yeem muab tau.

Customized capsules shells (loj, xim, khoom)

Customized fwj (loj, xim, khoom, style)

Customized ntim (nqus foil ntim, thawv, nruas)

Customized daim ntawv lo (xim zaj duab xis, matte zaj duab xis, daim npog qhov muag)

Dab tsi yog Cov txiaj ntsig ntawm CMS121

1. Anti-inflammatory teebmeem: CMS121 nthuav tawm cov khoom muaj zog tiv thaiv kab mob, ua rau nws muaj kev cia siab rau kev kho mob ntawm ntau yam mob. Kev mob plab ua lub luag haujlwm tseem ceeb hauv cov kab mob xws li mob caj dab rheumatoid, kab mob plab hnyuv, thiab cov kab mob neurodegenerative. Los ntawm modulating inflammatory pathways thiab txo cov zus tau tej cov pro-inflammatory molecules, CMS121 muaj peev xwm los txo o thiab cuam tshuam cov tsos mob. Qhov no tuaj yeem ua rau kev txhim kho kev tswj hwm thiab kev ua neej zoo rau cov tib neeg raug kev txom nyem los ntawm cov xwm txheej no.

2. Neuroprotective zog: CMS121 tau qhia cov teebmeem neuroprotective hauv kev tshawb fawb preclinical, qhia nws lub peev xwm los kho cov kab mob neurodegenerative. Cov xwm txheej zoo li Alzheimer's thiab Parkinson's yog tus cwj pwm los ntawm kev poob ntawm cov neurons thiab kev txawj ntse poob. CMS121 tau pom los tiv thaiv oxidative stress-induced neuronal puas thiab txo neuroinflamation, ob qho tib si uas pab rau neurodegeneration. Los ntawm kev khaws cov neuronal noj qab haus huv thiab kev ua haujlwm, CMS121 tuaj yeem ua rau cov kab mob qeeb zuj zus thiab tuaj yeem txhim kho kev txawj ntse hauv cov tib neeg cuam tshuam.

3. Muaj peev xwm tiv thaiv kab mob qog noj ntshav: CMS121 tau pom tias muaj kev cuam tshuam los tiv thaiv kab mob hauv cov kev tshawb fawb ua ntej. Nws inhibits kev loj hlob ntawm cov qog nqaij hlav cancer thiab induces apoptosis, muaj peev xwm muab txoj hauv kev tshiab rau kev kho mob qog noj ntshav. Los ntawm kev tsom mus rau cov kev taw qhia tshwj xeeb koom nrog hauv cov qog loj hlob thiab kev ciaj sia, CMS121 muaj peev xwm xaiv tua cov qog nqaij hlav cancer thaum txo qis kev puas tsuaj rau cov hlwb noj qab haus huv. Qhov no ua rau nws yog tus neeg sib tw txaus siab rau kev tshawb fawb ntxiv hauv kev tawm tsam mob qog noj ntshav thiab tuaj yeem ua txoj hauv kev rau kev txhim kho cov tshuaj tiv thaiv kab mob tshiab.

4. Antioxidant zog: CMS121 nthuav tawm cov haujlwm antioxidant, uas muaj txiaj ntsig zoo rau kev noj qab haus huv thiab kev noj qab haus huv. Kev ntxhov siab oxidative, tshwm sim los ntawm qhov tsis sib xws ntawm cov tshuaj tua kab mob antioxidant thiab cov pa oxygen reactive, cuam tshuam rau ntau yam kab mob, suav nrog cov kab mob neurodegenerative, kab mob plawv, thiab kev laus. Los ntawm kev tshem tawm cov dawb radicals thiab txo cov kev puas tsuaj oxidative, CMS121 tuaj yeem pab tiv thaiv cov hlwb thiab cov ntaub so ntswg los ntawm oxidative kev nyuaj siab ntsig txog kev puas tsuaj, uas tuaj yeem pab txhawb kev noj qab haus huv.

5. Tissue-protective effects: Preclinical kev tshawb fawb tau qhia tias CMS121 muaj cov ntaub so ntswg tiv thaiv. Nws tau raug pom los tiv thaiv cov ntaub so ntswg puas tsuaj thiab khaws cia lub cev ua haujlwm hauv cov qauv ua ntej ntawm ntau yam kab mob, suav nrog ischemia-reperfusion raug mob thiab mob ntsws mob. Cov kev tshawb pom no qhia tias CMS121 tuaj yeem muaj cov ntawv thov tseem ceeb hauv thaj chaw ntawm cov ntaub so ntswg engineering, tshuaj kho dua tshiab, thiab hloov pauv los ntawm kev tiv thaiv cov ntaub so ntswg los ntawm kev puas tsuaj thiab txhawb nqa lawv cov kev tsim kho tshiab thiab rov zoo.

6. Muaj peev xwm rau kev kho ua ke: CMS121 tau pom cov lus cog tseg hauv kev kho ua ke. Nws tuaj yeem txhim kho kev ua tau zoo ntawm cov kev kho mob uas twb muaj lawm lossis sib koom ua ke nrog lwm cov tshuaj kho mob los txhim kho cov txiaj ntsig. Cov tshuaj sib xyaw ua ke ntau yam kev ua haujlwm, suav nrog kev tiv thaiv kab mob, neuroprotective, thiab tshuaj tiv thaiv kab mob, ua rau nws yog tus neeg sib tw txaus nyiam rau kev sib xyaw ua ke cov tswv yim kho mob tsom rau cov kab mob nyuaj.

Synthesis thiab Preparation of 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1, 2-diol

Kev sib xyaw thiab kev npaj ntawm 4-[4-(Cyclopentyloxy)-2-quinolinyl]-1,2-benzenediol (CMS121) koom nrog ntau cov tshuaj tiv thaiv thiab cov txheej txheem. Txawm hais tias cov ntsiab lus tshwj xeeb hais txog kev sib xyaw ntawm CMS121 tej zaum yuav tsis yooj yim, Kuv tuaj yeem muab cov ntsiab lus dav dav ntawm cov txheej txheem hluavtaws feem ntau siv hauv cov tshuaj lom neeg rau cov tshuaj quinolinyl zoo sib xws. Ntawm no yog ib daim ntawv qhia dav dav ntawm cov txheej txheem synthesis thiab npaj:

1. Cov ntaub ntawv pib: Lub synthesis ntawm CMS121 feem ntau pib nrog cov khoom lag luam pib. Cov no tuaj yeem suav nrog quinoline derivatives, cyclopentanol, thiab benzenediol lossis lwm yam sib txuas, nyob ntawm seb cov qauv tshuaj xav tau.

2. Kev tiv thaiv cov pab pawg ua haujlwm: Txhawm rau kom muaj kev sib txawv ntawm cov txheej txheem sib xyaw ua ke, nws yuav tsim nyog los tiv thaiv cov pab pawg ua haujlwm tshwj xeeb uas muaj nyob hauv cov khoom pib. Cov kauj ruam no suav nrog kev siv cov pab pawg tiv thaiv tsim nyog uas tuaj yeem raug tshem tawm tom qab kom nthuav tawm cov chaw xav tau.

3. Tsim cov ntsiab lus nruab nrab: Ntau yam kev cuam tshuam, xws li condensation, alkylation, lossis oxidation, tej zaum yuav raug ua hauj lwm los tsim cov ntsiab lus nruab nrab. Cov tshuaj tiv thaiv no pab qhia txog cov pab pawg tsim nyog thiab kev hloov kho los tsim cov qauv quinolinyl uas xav tau.

4. Cyclization lossis nplhaib tsim: Cov kauj ruam cyclization cuam tshuam nrog kev kaw lub nplhaib hauv cov molecule, feem ntau ntawm cov tshuaj tiv thaiv intramolecular. Cyclization feem ntau yog ib kauj ruam tseem ceeb hauv kev tsim cov quinolinyl compounds thiab tej zaum yuav ua tiav los ntawm tej yam kev mob xws li kub, acid catalysis, los yog siv cov reagents tsim nyog.

5. Kev tshem tawm cov pab pawg tiv thaiv: Thaum cov khoom siv hluav taws xob xav tau tau txais, txhua pab pawg tiv thaiv siv ua ntej yuav tsum tau xaiv tshem tawm kom nthuav tawm cov pab pawg ua haujlwm kawg ntawm CMS121.

6. Purification thiab characterization: Tom qab cov synthesis tiav, lub resulting CMS121 compound yuav tsum tau purified thiab tus yam ntxwv los xyuas kom meej nws cov chemical integrity thiab purity. Qhov no feem ntau suav nrog cov txheej txheem xws li kem chromatography, crystallization, lossis recrystallization kom tau txais cov qauv ntshiab.

CMS121 yog dab tsi

1. Cov kab mob hauv plab: Cov tshuaj muaj cov tshuaj tiv thaiv kab mob, xws li CMS121, muaj peev xwm ua rau mob plab hnyuv, nrog rau xeev siab, ntuav, thiab raws plab. Cov teebmeem no feem ntau cuam tshuam nrog inhibition ntawm inflammatory pathways thiab tuaj yeem tshwm sim thaum muaj kev cuam tshuam nrog cov txheej txheem hauv plab hnyuv.

2. Cov kab mob siab thiab lub raum toxicity: Raws li CMS121 cuam tshuam nrog ntau txoj hauv kev ntawm tes thiab lub hom phiaj, nws yog ib qho tseem ceeb uas yuav tau tshawb xyuas nws cov kev cuam tshuam rau daim siab thiab lub raum ua haujlwm. Qee lub tebchaw tuaj yeem ua rau muaj toxicity ntawm cov kabmob no, ua rau hepatotoxicity lossis nephrotoxicity.

3. Cov tshuaj tsis haum: Cov tshuaj tsis haum yog ib qho kev txhawj xeeb uas cuam tshuam nrog cov tshuaj kho mob. Cov tib neeg tuaj yeem ua rau muaj qhov tsis hnov ​​​​tsw lossis ua xua rau qee cov molecules, uas tuaj yeem tshwm sim raws li daim tawv nqaij ua pob, khaus, o, lossis txawm tias muaj kev cuam tshuam hnyav xws li anaphylaxis. Nws yog ib qho tseem ceeb los soj ntsuam seb CMS121 puas tuaj yeem ua rau muaj kev tsis haum tshuaj rau cov tib neeg raug mob.

4. Cov teebmeem ntawm cov hlab plawv: CMS121 tau pom tias muaj cov khoom tiv thaiv kab mob, uas tuaj yeem cuam tshuam rau cov hlab plawv.

5. Cov teebmeem Hormonal: CMS121 kev sib cuam tshuam hauv lub cev tuaj yeem cuam tshuam cov tshuaj hormones. Kev cuam tshuam ntawm endocrine tuaj yeem tshwm sim los ntawm kev hloov kho ntawm cov kev taw qhia tshwj xeeb, uas tuaj yeem cuam tshuam rau cov tshuaj hormone synthesis, secretion, lossis receptor kev sib cuam tshuam.

6. Central Nervous System (CNS) cuam tshuam: Raws li CMS121 nthuav tawm cov khoom tiv thaiv neuroprotective, nws yog ib qho tseem ceeb rau kev ntsuam xyuas nws qhov cuam tshuam rau hauv nruab nrab lub paj hlwb. Thaum neuroprotection muaj txiaj ntsig zoo, kev hloov pauv hauv neurotransmitter muaj nuj nqi lossis CNS kev ua haujlwm tuaj yeem ua rau cov kev mob tshwm sim tsis zoo xws li kiv taub hau, tsis meej pem, lossis kev hloov pauv hauv lub siab lossis tus cwj pwm.

Hoobkas

Xi'an Sonwu nyob hauv ib qho chaw uas muaj ib puag ncig zoo nkauj, npog thaj tsam ntawm 10,{1}} square meters. Lub Hoobkas muaj cov cuab yeej tsim khoom siab heev, thiab pab pawg kws tshaj lij tau tsim khoom zoo, huv si, thiab huv si, nrog cov khoom txaus txaus. Raws li kev coj noj coj ua ntawm lub tuam txhab, cov kws tshawb fawb tau hais kom tsim cov khoom tshiab. Cov hauv qab no yog qhov chaw sim ntawm peb lub chaw soj nstuam, cov cuab yeej ntsuas qib siab, thiab cov kws tshaj lij kev sim, nrog tus cwj pwm nruj los muab cov ntaub ntawv tseem ceeb rau peb cov khoom thiab muab peb cov neeg siv khoom zoo.

Daim ntawv pov thawj

Ntim

Tsis ntev los no Logistics Record

Ntxiv nrog rau kev lees paub cov khoom zoo, lwm qhov tseem ceeb tshaj plaws yog cov neeg tuaj yeem tau txais cov khoom lag luam zoo. Yog li, Xi'an Sonwu muab txhua yam kev xa khoom raws li kev xav tau sib txawv.

FAQ

1. Yuav nug li cas?

Koj tuaj yeem tiv tauj peb ntawm email, xov tooj, lossis social media.

2. Yuav ua li cas lav qhov zoo ntawm cov khoom?

Txhua batch yuav tsum tau kuaj kom peb tuaj yeem muab COA rau cov neeg siv khoom. Tsis tas li ntawd, peb cov khoom dhau qhov kev xeem: HPLC, UV, GC, TLC, thiab lwm yam. Thiab peb kuj koom tes nrog peb tog, xws li, SGS.

3. Yuav ntim thiab khaws cov khoom li cas?

Pob: Lub tshuab nqus tsev ntim cov ntawv ntim & ntim cov ntawv xa tawm qib nruas lossis pob raws li cov neeg siv khoom xav tau

Cia: Rau lub sijhawm luv luv, koj tuaj yeem khaws cia rau hauv qhov chaw qhuav thiab txias thiab ua kom tsis txhob tshav ntuj.

Yog tias koj txaus siab rau peb lub tuam txhabcm121 uahmoov, thov hu rau Xi'an Sonwu Biotech Co. Ltd.

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