Deoxyguanosine hmoov

Deoxyuridine yog dab tsi

Deoxyguanosine hmoovyog ib qho nucleoside tsim los ntawm lub hauv paus guanine thiab deoxyribose qab zib molecule. Nws yog ib qho tseem ceeb ntawm DNA, ua lub luag haujlwm tseem ceeb hauv kev khaws cov ntaub ntawv caj ces thiab xa mus. 1. Cov qauv ntawm Deoxyguanosine:

Deoxyguanosine muaj cov qauv tshwj xeeb uas ua ke nrog lub hauv paus guanine thiab deoxyribose qab zib molecule. Guanine yog lub hauv paus purine, tus cwj pwm los ntawm cov qauv fused ob lub nplhaib. Nws muaj ib lub nplhaib pyrimidine thiab ib lub nplhaib imidazole.

Cov piam thaj deoxyribose yog tsib-carbon (pentose) qab zib tau los ntawm ribose, nrog qhov sib txawv tseem ceeb. Deoxyribose ploj lawm ib qho oxygen atom txuas rau lub thib ob carbon atom (C2), uas txawv nws ntawm ribose.

Hauv deoxyguanosine, lub hauv paus guanine txuas rau thawj carbon atom (C1) ntawm deoxyribose los ntawm -N-glycosidic daim ntawv cog lus. Qhov kev sib txuas no tshwm sim ntawm cov piam thaj anomeric carbon thiab nitrogen atom (N9) ntawm guanine.

2. Kev ua haujlwm ntawm Deoxyguanosine:

Deoxyguanosine plays ob peb lub luag haujlwm tseem ceeb hauv DNA qauv thiab kev ua haujlwm:

ib. DNA Structure: Deoxyguanosine, nrog rau adenine, cytosine, thiab thymine, yog ib qho ntawm plaub lub hauv paus nucleotide uas ua rau DNA. Ua ke, cov hauv paus no tsim cov txheej txheem caj ces lub luag haujlwm rau kev nkag mus rau lub cev tus yam ntxwv thiab cov yam ntxwv. Deoxyguanosine ua khub nrog cytosine los ntawm peb daim ntawv cog lus hydrogen, pab txhawb rau ob lub helical qauv ntawm DNA. Kev sib koom ua ke tshwj xeeb ntawm deoxyguanosine nrog cytosine ua kom muaj tseeb replication thiab kis ntawm cov ntaub ntawv caj ces.

b. DNA Replication: Thaum lub sij hawm DNA replication, deoxyguanosine ua ib tug precursor rau synthesis ntawm DNA tshiab strands. DNA polymerases, cov enzymes lub luag hauj lwm rau DNA replication, siv deoxyguanosine triphosphate (dGTP), ib tug phosphorylated daim ntawv ntawm deoxyguanosine, muab guanine mus rau hauv lub loj hlob DNA molecule. Cov kauj ruam no ua kom muaj tseeb duplication ntawm caj ces code.

c. DNA Kho: Deoxyguanosine kuj koom nrog hauv DNA kho mechanisms. Nws koom nrog DNA kev puas tsuaj rau kev lees paub thiab kev taw qhia txoj hauv kev. Thaum DNA puas lawm, qee cov enzymes txheeb xyuas qhov chaw puas, tshem tawm cov nucleotide puas, thiab hloov nws nrog qhov tseeb. Cov txheej txheem kho no yog nyob ntawm cov pas dej txaus ntawm deoxyguanosine thiab nws cov ntawv phosphorylated.

d. Oxidative Stress Defense: Guanine, lub hauv paus tam sim no nyob rau hauv deoxyguanosine, yog qhov raug oxidative puas tsuaj. Reactive oxygen hom (ROS) generated thaum lub sij hawm ib txwm cellular metabolism los yog raug rau ib puag ncig yam yuav oxidatively hloov guanine, ua rau DNA puas. Cov oxidation ntawm guanine tuaj yeem ua rau muaj kev tsim ntawm 8-oxo-7, 8-dihydroguanine (8-oxoG), ib qho kab mob DNA. Cells muaj cov txheej txheem tiv thaiv, xws li cov enzymes tshwj xeeb xws li 8-oxoguanine DNA glycosylase, uas paub thiab tshem tawm 8-oxoG qhov txhab, tiv thaiv kev hloov pauv.

3. Qhov tseem ceeb hauv cov txheej txheem lom neeg:

Deoxyguanosine qhov tseem ceeb txuas ntxiv dhau DNA qauv thiab rov ua dua:

ib. Mutagenesis thiab Carcinogenesis: Thaum DNA puas tshwm sim, suav nrog oxidative puas tsuaj rau guanine, nws tuaj yeem ua rau DNA hloov pauv, ua rau muaj kab mob caj ces lossis mob qog noj ntshav. Yog li ntawd, kev nkag siab txog cov khoom ntawm deoxyguanosine thiab kev hloov kho guanine yog qhov tseem ceeb rau kev kawm txog cov txheej txheem mutagenesis.

b. Pharmacology thiab Therapeutics: Deoxyguanosine analogs thiab derivatives tau kawm ntau yam hauv kev lag luam tshuaj. Hloov kho cov ntaub ntawv deoxyguanosine tau tsim rau ntau yam kev siv kho mob, suav nrog tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob. Cov tebchaw no tuaj yeem xaiv inhibit DNA synthesis thiab cuam tshuam cov txheej txheem cellular tseem ceeb.

4. Kev Ntsuas thiab Kev Ntsuas:

Cov kws tshawb fawb siv ntau yam kev tshuaj ntsuam xyuas los kuaj thiab ntsuas deoxyguanosine. Cov txheej txheem no suav nrog kev ua haujlwm siab ua kua chromatography (HPLC), kua chromatography-mass spectrometry (LC-MS), thiab capillary electrophoresis. Cov tswv yim no pab ntsuas cov qib deoxyguanosine hauv cov qauv tshuaj lom neeg thiab muab kev nkag siab txog DNA puas, kho cov txheej txheem, thiab cuam tshuam ntawm mutagens.

Lub purity ntawm peb lub tuam txhab deoxyguanosine capsule ntxiv tuaj yeem ncav cuag 99 feem pua. Tsis tas li, peb cov nqi sib tw heev piv rau lwm lub tuam txhab. Yog tias koj xav paub ntau ntxiv, thov hu rau Xi'an Sonwu Biotech Co. Ltd.

Deoxyuridine Nqe

Xi'an Sonwu muaj kev paub dhau los hauv kev lag luam thoob ntiaj teb thiab kev noj qab haus huv kev lag luam. Reputation-raws li zoo ua ntej yog lub hauv paus ntsiab lus ntawm Xi'an Songwu Company. Xi'an Sonwu nruj me ntsis tswj cov khoom zoo, yog li xaiv cov ntaub ntawv pib nrog raw cov ntaub ntawv. Tsis tas li ntawd, peb tswj txhua qhov kev nthuav dav thiab txo cov nqi kom peb cov neeg siv khoom tau txais cov khoom lag luam zoo tshaj plaws. Raws li cov no, cov neeg siv khoom tau txais kev qhuas siab rau peb cov khoom. Yog tias koj xav tau deoxyguanosine capsule, nrhiav Xi'an Sonwu Biotech Co. Ltd.

Peb ua kom paub tseeb ntawm cov khoom zoo, yog li cov qauv tuaj yeem muab tau. Ntawm no yog qhov ntau.

Customers'Cov lus zoo

Kev Pabcuam OEM

Xi'an Sonwu tsis tsuas yog tuaj yeem muab cov khoom zoo deoxyguanosine hmoovtab sis kuj muab deoxyguanosine capsule.

Yog li txhua tus neeg siv khoom tuaj yeem kho cov tshuaj ntsiav lawv xav tau. Thiab cov khoom hauv qab no tuaj yeem muab tau.

Customized capsules shells (loj, xim, khoom)

Customized fwj (loj, xim, khoom, style)

Customized ntim (nqus foil ntim, thawv, nruas)

Customized daim ntawv lo (xim zaj duab xis, matte zaj duab xis, daim npog qhov muag)

Deoxyguanosine yog dab tsi

Deoxyguanosine yog ib qho nucleoside tsim los ntawm lub hauv paus guanine thiab deoxyribose qab zib molecule.

1. Guanine: Guanine yog ib qho ntawm plaub lub hauv paus nitrogenous muaj nyob hauv DNA thiab RNA. Nws yog ib lub hauv paus purine, lub ntsiab lus nws muaj ob lub nplhaib qauv. Guanine muaj cov tshuaj formula C5H5N5O thiab molecular hnyav 151.13 g/mol.

Cov qauv ntawm guanine muaj ob lub nplhaib fused - lub nplhaib pyrimidine thiab ib lub nplhaib imidazole. Lub nplhaib pyrimidine muaj plaub lub atoms thiab ob lub nitrogen atoms, thaum lub nplhaib imidazole muaj ob lub atoms thiab peb nitrogen atoms.

Guanine muaj ntau pab pawg ua haujlwm. Nws muaj carbonyl (=O) thiab amine (-NH2) pawg txuas nrog cov pa roj carbon atom ntawm cov nplhaib. Cov pab pawg ua haujlwm no pab txhawb rau cov tshuaj reactivity thiab hydrogen bonding peev xwm ntawm guanine.

2. Deoxyribose Qab Zib: Deoxyguanosine muaj ib deoxyribose qab zib molecule. Deoxyribose yog tsib-carbon qab zib lossis pentose uas yog ib feem tseem ceeb ntawm DNA. Nws yog ib daim ntawv hloov kho ntawm ribose, cov suab thaj pom hauv RNA, nrog ib pawg hydroxyl (-OH) uas ploj lawm los ntawm cov pa roj carbon thib ob (C2). Qhov tsis muaj ntawm pawg hydroxyl no muab deoxyribose nws lub npe.

Cov qauv ntawm deoxyribose qab zib zoo ib yam li ribose, tshwj tsis yog qhov tsis muaj oxygen atom ntawm C2 txoj haujlwm. Deoxyribose muaj tsib carbon atoms, kaum hydrogen atoms, thiab tsib oxygen atoms, nrog ib tug tshuaj formula C5H10O4.

Cov pa roj carbon atoms hauv deoxyribose qab zib yog suav los ntawm 1 txog 5. Lub hauv paus guanine yog txuas rau thawj carbon atom (C1) ntawm deoxyribose los ntawm glycosidic daim ntawv cog lus. Qhov kev txuas no tso cai rau tsim cov nucleoside, uas yog kev sib xyaw ntawm lub hauv paus thiab qab zib.

3. Glycosidic Bond: Qhov txuas ntawm guanine rau deoxyribose qab zib hauv deoxyguanosine yog tsim los ntawm glycosidic daim ntawv cog lus. Tshwj xeeb, guanine txuas rau C1 txoj haujlwm ntawm deoxyribose ntawm -N-glycosidic daim ntawv cog lus.

Daim ntawv cog lus glycosidic suav nrog cov kev sib txuas ntawm cov pa roj carbon monoxide ntawm qab zib (C1) thiab nitrogen atom (N9) ntawm guanine. Cov ntawv cog lus no tsim ntawm pawg hemiacetal ntawm cov piam thaj thiab ib pawg amine ntawm nucleobase.

Txoj hauj lwm ntawm glycosidic daim ntawv cog lus yog txhais raws li vim hais tias pawg hydroxyl ntawm cov anomeric carbon yog nyob rau hauv lub opposite kev taw qhia los ntawm nitrogenous puag. -glycosidic daim ntawv cog lus ruaj khov thiab feem ntau pom muaj nyob hauv DNA nucleotides.

Molecular Formula thiab Nyhav: Kev sib xyaw guanine thiab deoxyribose ua rau tsim deoxyguanosine. Cov mis mos molecular ntawm deoxyguanosine yog C10H13N5O4, thiab nws muaj qhov hnyav ntawm 283.24 g / mol.

Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias deoxyguanosine feem ntau tsis pom zoo li cov molecule dawb hauv cov hlwb tab sis yog ib feem ntawm cov qauv nucleic acid loj dua, xws li DNA. Deoxyguanosine tuaj yeem ua phosphorylated los ua deoxyguanosine monophosphate (dGMP) thiab ntxiv phosphorylated los ua deoxyguanosine diphosphate (dGDP) thiab deoxyguanosine triphosphate (dGTP). Cov ntaub ntawv phosphorylated ntawm deoxyguanosine yog qhov tseem ceeb rau DNA synthesis, kho, thiab lwm yam txheej txheem ntawm tes.

Dab tsi yog Deoxyguanosine siv rau

Deoxyguanosine (dG) yog ib qho nucleoside uas ua haujlwm tseem ceeb hauv lub tsev thaiv rau kev sib txuas ntawm deoxyguanosine monophosphate (dGMP), nucleotide pom hauv DNA. Deoxyguanosine, nrog rau lwm cov nucleosides (deoxyadenosine, deoxycytidine, thiab deoxythymidine), ua lub luag haujlwm tseem ceeb hauv DNA replication, kho, thiab cellular txheej txheem. Nov yog cov lus piav qhia ntxaws ntxiv ntawm kev siv thiab kev ua haujlwm ntawm deoxyguanosine:

1. DNA Synthesis: Deoxyguanosine yog ib qho tseem ceeb hauv kev sib txuas ntawm DNA. Thaum lub sij hawm DNA replication, DNA polymerases siv deoxyguanosine triphosphate (dGTP) ua substrate ntxiv guanine (G) rau cov DNA loj hlob strand. Cov txheej txheem no ua kom muaj tseeb replication ntawm cov ntaub ntawv caj ces encoded hauv DNA molecule.

2. Genetic Code thiab Base Pairing: Deoxyguanosine, tshwj xeeb hauv nws daim ntawv phosphorylated raws li dGMP, yog lub luag haujlwm rau kev sib koom ua ke nrog cytosine (C) hauv DNA. Lub hauv paus ua ke ntawm G thiab C stabilizes DNA ob chav helix qauv. Kev sib raug zoo ntawm deoxyguanosine nrog cytosine yog qhov tseem ceeb rau kev tswj hwm kev ncaj ncees ntawm DNA molecule thiab ua kom muaj kev ncaj ncees ntawm DNA replication.

3. DNA Kho: Deoxyguanosine kuj koom nrog cov txheej txheem kho DNA. Thaum DNA raug puas tsuaj vim muaj ntau yam xws li raug UV hluav taws xob lossis tshuaj mutagens, cov txheej txheem kho tshwj xeeb raug qhib kom rov ua cov DNA sib lawv liag. Thaum lub sijhawm kho, cov hauv paus puas tuaj yeem raug tshem tawm thiab hloov nrog cov nucleotide tsim nyog. Deoxyguanosine, uas yog ib feem ntawm dGMP, tuaj yeem muab tso ua ke los hloov cov guanine uas puas lawm, pab txhawb kev rov qab los ntawm cov DNA kom raug.

4. Zog Metabolism: Deoxyguanosine, nrog rau lwm cov nucleosides, plays lub luag haujlwm hauv cellular zog metabolism. Nucleosides tuaj yeem degraded los tsim cov hauv paus dawb thiab ribose-1-phosphate, uas tuaj yeem nkag mus rau ntau txoj hauv kev metabolic. Piv txwv li, nyob rau hauv txoj kev purine khaws cia, deoxyguanosine tuaj yeem phosphorylated thiab hloov mus rau deoxyguanosine monophosphate (dGMP), uas yog tom qab ntawd ntxiv phosphorylated los tsim deoxyguanosine triphosphate (dGTP). Cov nucleotides no yog qhov tseem ceeb rau cov txheej txheem uas xav tau lub zog, xws li DNA synthesis thiab cell division.

5. Antiviral thiab Cancer Treatments: Deoxyguanosine thiab nws cov derivatives tau siv rau lawv cov peev xwm kho mob. Guanosine analogs, xws li acyclovir thiab ganciclovir, feem ntau yog siv cov tshuaj tiv thaiv kab mob uas tiv thaiv kab mob DNA replication los ntawm kev cuam tshuam nrog kev koom ua ke ntawm deoxyguanosine triphosphate (dGTP) rau hauv cov DNA loj hlob ntawm cov kab mob genomes. Cov tshuaj no tshwj xeeb tshaj yog tiv thaiv kab mob herpesviruses thiab siv los kho tus kab mob herpes.

Hauv kev kho mob qog noj ntshav, deoxyguanosine analogs, suav nrog 6-mercaptopurine thiab 6-thioguanine, tau siv los ua cov tshuaj tua kab mob. Cov analogs no tau muab tso rau hauv DNA ntawm kev faib cov qog nqaij hlav sai sai, cuam tshuam DNA replication thiab ua rau cov teebmeem cytotoxic.

Tsis tas li ntawd, deoxyguanosine thiab nws cov derivatives tau kawm txog lawv txoj haujlwm muaj peev xwm hauv kev kho noob thiab ua lub hom phiaj rau kev txhim kho cov tshuaj tiv thaiv kab mob. Targeting enzymes koom nrog hauv nucleotide metabolism, xws li cov luag haujlwm rau kev sib txuas lossis degradation ntawm deoxyguanosine, yog thaj chaw ntawm kev tshawb fawb nquag rau kev tsim kho tshiab.

Qhov txawv ntawm Guanine thiab Deoxyguanosine yog dab tsi

Guanine thiab deoxyguanosine yog cov molecules muaj feem xyuam nrog cov qauv sib txawv me ntsis thiab lub luag haujlwm sib txawv hauv cov txheej txheem ntawm tes. Nov yog cov lus piav qhia ntxaws txog qhov sib txawv ntawm guanine thiab deoxyguanosine:

1. Composition: Guanine: Guanine yog ib lub hauv paus purine, uas txhais tau hais tias nws muaj ib tug fused ob-ntiv nplhaib qauv. Nws muaj cov tshuaj formula C5H5N5O thiab molecular hnyav ntawm 151.13 g / mol. Guanine yog ib qho ntawm plaub lub hauv paus pom nyob rau hauv nucleic acids (DNA thiab RNA) thiab yog ib qho ntawm lub tsev thaiv ntawm DNA.

Deoxyguanosine: Deoxyguanosine, ntawm qhov tod tes, yog nucleoside tsim los ntawm guanine thiab deoxyribose qab zib molecule. Nws yog tsim thaum ib pab pawg hydroxyl (-OH) txuas rau thawj cov pa roj carbon monoxide deoxyribose qab zib hloov los ntawm nitrogenous puag guanine. Cov tshuaj formula ntawm deoxyguanosine yog C10H13N5O4 thiab nws qhov hnyav molecular yog 283.24 g / mol. Deoxyguanosine yog lub hauv paus rau kev sib txuas ntawm deoxyguanosine monophosphate (dGMP), nucleotide uas tau muab tso rau hauv DNA strands thaum rov ua dua.

2. Cov qauv: Guanine: Guanine muaj cov qauv tsim thiab muaj ob lub nplhaib fused - lub nplhaib pyrimidine thiab lub nplhaib imidazole. Lub nplhaib pyrimidine muaj plaub carbon thiab ob lub nitrogen atoms, thaum lub nplhaib imidazole muaj ob carbon thiab peb nitrogen atoms. Guanine muaj ntau pawg ua haujlwm, suav nrog peb pawg amine (-NH2) thiab ib pawg carbonyl (=O) pawg.

Deoxyguanosine: Deoxyguanosine muaj cov qauv zoo sib xws rau guanine tab sis nrog ntxiv ntawm deoxyribose qab zib molecule. Cov piam thaj deoxyribose yog tsib-carbon qab zib (pentose) uas tsim cov pob txha ntawm DNA. Nws muaj tib lub nplhaib qauv zoo li ribose, cov suab thaj pom hauv RNA, tab sis nrog ib daim ntawv deoxygenated. Cov piam thaj deoxyribose txuas rau thawj carbon atom (C1) ntawm guanine, thaum lub hauv paus nitrogenous txuas los ntawm thawj carbon.

3. Muaj nuj nqi: Guanine: Guanine yog ib qho ntawm plaub lub hauv paus nitrogenous hauv DNA thiab RNA. Hauv DNA, guanine puag khub nrog cytosine (C) los ntawm hydrogen bonds, pab txhawb rau ob chav helical qauv ntawm DNA. Hauv RNA, guanine tuaj yeem ua ke nrog cytosine tab sis feem ntau ua khub nrog uracil (U). Guanine, ua ib feem ntawm DNA thiab RNA, ua lub luag haujlwm tseem ceeb hauv kev xa cov ntaub ntawv caj ces thiab kev sib txuas ntawm cov protein.

Deoxyguanosine: Deoxyguanosine ua haujlwm ua ntej rau kev sib txuas ntawm deoxyguanosine monophosphate (dGMP), nucleotide uas tau muab tso rau hauv DNA thaum rov ua dua. Lub phosphorylation ntawm deoxyguanosine generates dGMP, uas yuav tau ntxiv phosphorylated los tsim deoxyguanosine diphosphate (dGDP) thiab deoxyguanosine triphosphate (dGTP). Cov phosphorylated cov ntaub ntawv ntawm deoxyguanosine muab lub zog phosphates uas xav tau rau DNA synthesis thiab lwm lub zog-yuav tsum tau cellular txheej txheem.

4. Lub luag hauj lwm hauv DNA: Guanine: Guanine, ua ib qho ntawm plaub lub hauv paus hauv DNA, pab txhawb rau txoj cai caj ces thiab lub hauv paus kev sib koom ua ke. Nws ua ke tshwj xeeb nrog cytosine los ntawm peb daim ntawv cog lus hydrogen, kom ntseeg tau tias muaj tseeb replication thiab kis ntawm cov ntaub ntawv caj ces.

Deoxyguanosine: Deoxyguanosine, ua ntej rau dGMP, yog qhov tseem ceeb rau kev koom ua ke ntawm guanine nucleotides rau hauv DNA. Thaum lub sij hawm DNA replication, DNA polymerases siv deoxyguanosine triphosphate (dGTP) ntxiv guanine rau DNA strand loj hlob, ua kom muaj tseeb DNA synthesis. Deoxyguanosine thiab nws cov phosphorylated derivatives ua lub luag haujlwm tseem ceeb hauv kev tswj hwm DNA kev ncaj ncees thiab kev ncaj ncees.

Hoobkas

Xi'an Sonwu nyob hauv ib qho chaw uas muaj ib puag ncig zoo nkauj, npog thaj tsam ntawm 10,000 square meters. Lub Hoobkas muaj cov cuab yeej tsim khoom siab heev, thiab pab pawg kws tshaj lij tau tsim khoom zoo, huv si, thiab huv si, nrog cov khoom txaus txaus. Raws li kev coj noj coj ua ntawm lub tuam txhab, cov kws tshawb fawb tau hais kom tsim cov khoom tshiab. Cov hauv qab no yog qhov chaw sim ntawm peb lub chaw soj nstuam, cov cuab yeej ntsuas qib siab, thiab cov kws tshaj lij kev sim, nrog tus cwj pwm nruj los muab cov ntaub ntawv tseem ceeb rau peb cov khoom thiab muab peb cov neeg siv khoom nrog kev paub zoo.

Daim ntawv pov thawj

Ntim

Tsis ntev los no Logistics Record

Ntxiv nrog rau kev lees paub cov khoom zoo, lwm qhov tseem ceeb tshaj plaws yog cov neeg tuaj yeem tau txais cov khoom lag luam zoo. Yog li, Xi'an Sonwu muab txhua yam kev xa khoom raws li kev xav tau sib txawv.

​​​

FAQ

1. Yuav nug li cas?

Koj tuaj yeem tiv tauj peb ntawm email, xov tooj, lossis social media.

2. Yuav ua li cas lav qhov zoo ntawm cov khoom?

Txhua batch yuav tsum tau kuaj kom peb tuaj yeem muab COA rau cov neeg siv khoom. Tsis tas li ntawd, peb cov khoom dhau qhov kev xeem: HPLC, UV, GC, TLC, thiab lwm yam. Thiab peb kuj koom tes nrog peb tog, xws li, SGS.

3. Yuav ntim thiab khaws cov khoom li cas?

Pob: Lub tshuab nqus tsev ntim cov ntawv ntim & ntim cov ntawv xa tawm qib nruas lossis pob raws li cov neeg siv khoom xav tau

Cia: Rau lub sijhawm luv luv, koj tuaj yeem khaws cia rau hauv qhov chaw qhuav thiab txias thiab ua kom tsis txhob tshav ntuj.

Yog tias koj txaus siab rau peb lub tuam txhabdeoxyguanosine hmoov, thov hu rau Xi'an Sonwu Biotech Co. Ltd.

Email:sales@sonwu.com

Cim npe nrov: Deoxyguanosine hmoov, Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, ntshiab, raw, mov, kev muag khoom