Canagliflozin hmoov

SGLT2 Inhibitor Canagliflozin
Canagliflozin hmoovbelongs rau sodium-glucose cotransporter ob inhibitors lossis SGLT2 inhibitors. SGLT2 yog ib qho tseem ceeb ntawm cov protein ua lub luag haujlwm rau cov piam thaj reabsorption hauv lub raum tubules. Thaum cov ntshav qab zib ntau dua li niaj zaus, ob lub raum yuav lim cov ntshav kom tshem tawm cov piam thaj hauv cov ntshav thiab tiv thaiv cov ntshav qab zib kom tsis txhob nce ntxiv. Txawm li cas los xij, thaum lub peev xwm reabsorption ntawm lub glomeruli nce mus txog saturation, qabzib siab tshaj qhov txwv no pib tawm hauv cov zis. SGLT2 ua lub luag haujlwm tseem ceeb hauv lub cev los ntawm kev pab lub raum rov qab nqus cov piam thaj, tab sis yog tias lub raum dhau ntawm cov lim dej, nws tuaj yeem ua rau muaj cov piam thaj ntau ntxiv, hu ua glycosuria. Canagliflozin tuaj yeem cuam tshuam SGLT2, uas tuaj yeem txo qhov nqus ntawm cov piam thaj los ntawm lub raum kom cov piam thaj hauv lub cev tawm hauv cov zis, tom qab ntawd txo cov ntshav qab zib.
Tam sim no, ntau cov ntaub ntawv pov thawj-raws li cov tshuaj tau lees paub tias canagliflozin tuaj yeem tiv thaiv cov hlab plawv thiab txhim kho cov kab mob hauv lub raum thaum txo cov ntshav qab zib thiab txo cov nyhuv ntawm cov proteinuria. Clinically, cov neeg mob uas muaj ntshav qab zib nephropathy feem ntau pom zoo kom siv canagliflozin kom txo cov ntshav qab zib thaum tiv thaiv ob lub raum thiab txhim kho cov tsos mob ntawm lub raum. Rau cov neeg mob uas tsis muaj ntshav qab zib nephropathy tab sis nrog kev kho mob ntshav qab zib thiab lwm yam kab mob glomerular, canagliflozin tuaj yeem txiav txim siab yog tias lub raum ua haujlwm tau tso cai. Tom qab tag nrho, nws tuaj yeem txhim kho cov kab mob plawv thiab lub raum. Nws yog qhov tseem ceeb tshaj plaws rau kev poob phaus thiab ob peb cov xwm txheej hypoglycemic thiab muaj kev cog lus zoo. Yog tias koj txaus siab rau canagliflozin nyoos, koj tuaj yeem tiv tauj Xi'an Sonwu, Xi'an Sonwu yuav muab cov lus teb rau koj txog cov khoom no.

Certificate of Analysis

Qhov twg yuav Canagliflozin
Xi'an Sonwu Biotech Co., Ltd. yog ib lub chaw tsim khoom thiab distributor nrog ntau tshaj kaum xyoo ntawm kev paub. Nws muaj kev koom tes dav thiab ruaj khov nrog cov teb chaws thoob ntiaj teb hauv Asmeskas, Asia, Europe, thiab Oceania. Xi'an Sonwu ib txwm hais rau cov khoom zoo ua ntej. Pab txhua tus neeg siv khoom zoo thiab txaus siab rau txhua tus neeg siv khoom yog Xi'an Sonwu txoj kev nrhiav. Xi'an Sonwu nruj me ntsis tswj txhua kauj ruam, los ntawm kev xaiv cov khoom siv raw, thiab nrhiav cov khoom zoo los ntawm txhua yam, xws li kev xaiv cov khoom siv, kev tsim khoom, kev kuaj cov qauv, thiab cov neeg ua haujlwm tshaj lij. Tsis tas li ntawd, Xi'an Sonwu siv zog ua txhua yam kom txo tau cov nqi thiab tso cai rau cov neeg siv khoom kom tau txais cov khoom lag luam nrog cov nqi siab. Raws li cov no, cov neeg siv khoom tau muab cov lus pom zoo rau cov khoom. Yog li yog tias koj xav tau canagliflozin poob hmoov, thov hu rau Xi'an Sonwu.
Xi'an Sonwu thaum kawg ua kom cov khoom zoo thiab muab cov qauv. Ntawm no yog qhov ntau.

Cov neeg siv khoom 'Cov lus pom zoo

Canagliflozin txo cov ntshav qab zib li cas
Inhibits sodium-glucose cotransporter
Raws li SGLT2 inhibitor, canagliflozin feem ntau ua rau SGLT2, txo qis lub raum lub raum tubule qabzib reabsorption rau 100-130 g/d, thiab ua rau cov kua nplaum tso zis ntau ntxiv rau 50-80 g/d, yog li kho T2DM cov neeg mob ntshav qab zib. Hauv kev sim tsiaj, tom qab muab cov canagliflozin rau nas rau 24 teev, qhov siab ntawm canagliflozin tau kuaj pom hauv cov hnyuv me, qhia tias canagliflozin tuaj yeem muaj kev cuam tshuam rau SGLT1. Nws lub tswv yim yuav yog tias canagliflozin inhibits plab hnyuv SGLT1, ib ntus inhibits plab hnyuv siab raum, nce postprandial tag nrho glucagon-zoo li peptide-1 (GLP-1) qib, ib ntus txo qis postprandial insulin-stimulating polypeptide qib thiab txo qis postprandial polypeptide. Insulin secretion, yog li txhim kho cov ntshav qab zib tswj. Yog li ntawd, canagliflozin tsis tsuas yog txhim kho cov tshuaj insulin los ntawm inhibiting lub raum SGLT2 tab sis kuj qee qhov inhibits SGLT1 kom ncua kev nqus cov piam thaj hauv cov hnyuv thiab txo qis cov ntshav qabzib tom qab, uas muaj ob qho kev cuam tshuam ntawm -glucosidase inhibitor zoo li kev loj hlob thiab lub raum mechanism.

Txhim kho islet muaj nuj nqi
Cov ntshav qabzib hauv cov ntshav tau tswj hwm los ntawm insulin tsis kam thiab -cell ua haujlwm, thiab txo qis ntawm adiponectin qib tshwm sim los ntawm visceral rog tsub zuj zuj yog qhov tseem ceeb ntawm kev ua haujlwm ntawm insulin. Canagliflozin tuaj yeem nce qib adiponectin hauv cov ntshav thiab txo qis cov ntaub so ntswg adipose thiab ectopic rog, txo cov tshuaj insulin. Cov neeg mob uas muaj lub cev hnyav dua (BMI) nce qib glucagon lossis FFAs, txo lub cev hnyav, thiab txo cov tshuaj insulin tom qab kho canagliflozin; Cov neeg mob uas qis BMI tau kho nrog canagliflozin vim kev txhim kho cov ntshav qab zib; Insulin lub luag haujlwm hauv kev txhawb nqa cov roj synthesis thiab tso zis tawm ntawm lub zog (qabzib) nce, ua rau lub cev hnyav.

Beta cell proliferation
Hyperglycemia muaj ntau txoj hauv kev metabolic thaum lub sijhawm glycolysis tuaj yeem ua rau cov hlab ntsha peripheral puas tsuaj thiab ua rau mob ntshav qab zib polyneuropathy. Ntxiv nrog rau kev hnov ​​​​mob neuropathy, tus naj npawb ntawm cov fibers me me ntawm cov hlab ntsha hauv cov hlab ntsha tuaj yeem txo qis, txo qhov ntim ntom ntom ntawm cov hlwb pancreatic. Tom qab kev kho mob canagliflozin, cov hlab ntsha parasympathetic ntom ntom hauv cov islets thiab cov hlab ntsha fiber ntau hauv cov epidermis tau nce, uas txhim kho qhov poob ntawm unmyelinated me me fibers nyob rau theem pib ntawm DPN, yog li nce V .

Canagliflozin siv rau dab tsi

1. Poob qhov hnyav thiab lipid-txo cov teebmeem
Canagliflozin hmoovtuaj yeem txo lub cev hnyav hauv cov neeg rog rog lossis rog T2DM, thiab nrog rau lub sijhawm kho mob ntev, canagliflozin tuaj yeem ua lub luag haujlwm tseem ceeb hauv kev txo lub cev hnyav. Kev poob phaus thaum ntxov ntawm canagliflozin yog tshwm sim los ntawm cov kua dej tawm los ntawm cov nyhuv natriuretic ntawm canagliflozin. Kev poob phaus tom qab yog vim qhov txo qis ntawm calories thiab qhov tshwm sim ntawm cov rog rog.
Tom qab canagliflozin poob phaus hmoov kho, plab visceral rog thiab subcutaneous rog txo, thiab qib adiponectin nce, qhia tau hais tias canagliflozin tuaj yeem txo qhov rog-vim cov ntaub so ntswg inflammatory teb. Tsis tas li ntawd, canagliflozin inhibits inflammatory teb ntawm lub paj hlwb thiab pob txha pob txha cov leeg los ntawm excreting qabzib nyob rau hauv cov zis, txo cov piam thaj toxicity, thiab txhim kho kev rog rog thiab rog-txog metabolic ntshawv siab. Canagliflozin nce cov ntsiab lus ntawm mitochondrial DNA nyob rau hauv cov ntaub so ntswg adipose dawb thiab nce-tswj kev qhia ntawm mitochondrial noob hauv adipocytes xws li PGC-1, NRF1, COX5b, CPT1b, Acadm, thiab PPAR hauv adipocytes. Nws ncaj qha cuam tshuam rau cov rog rog lub zog noj, txhim kho cov haujlwm mitochondrial thiab fatty acid oxidation ntawm cov nqaijrog thiab cov rog rog, txo lub cev hnyav, rog rog, thiab WAT qhov hnyav, inhibits rog cell hypertrophy, thiab txhim kho cov ntshav qab zib thiab cov ntshav lipid metabolism tsis zoo tshwm sim. los ntawm kev rog.

2. Antihypertensive nyhuv
T2DM feem ntau nrog cov ntshav siab, ib qho kev pheej hmoo tseem ceeb rau cov teeb meem xws li lub plawv tsis ua hauj lwm thiab ua rau mob ntshav qab zib ntau ntxiv. Kev tswj cov ntshav siab yog lub hom phiaj tseem ceeb ntawm kev txo cov hlab plawv thiab lub raum txaus ntshai. Canagliflozin tuaj yeem txo qis systolic ntshav siab. Nyob rau hauv hyperglycemia, cov piam thaj ntau dhau nkag mus rau lub raum proximal tubular hlwb los ntawm SGLT2, txhawb kev tsim cov angiotensinogen hauv lub raum, ua kom cov renin-angiotensin system hauv lub raum, nce qib ntawm angiotensin II hauv lub raum, ua rau Sodium tuav, nce ntshav siab. Canagliflozin txo cov tiam ntawm ROS hauv PTC thiab ua rau kom cov kev qhia ntawm AGT hauv lub raum los ntawm kev thaiv SGLT2, inhibits oxidative kev nyuaj siab nyob rau hauv lub raum, thiab attenuates tubulointerstitial monocyte / macrophage infiltration, tubular fibrosis, thiab lub raum cortical Cell proliferation, yog li txo cov ntshav siab.

3. Txo cov uric acid
Cov neeg mob uas muaj ntshav qab zib hom 2 feem ntau yog nrog hyperuricemia, ua rau muaj kev puas tsuaj rau ntau lub hauv nruab nrog cev, ua rau mob plawv, kub siab, mob stroke, thiab lwm yam teeb meem, thiab ua kom lub raum puas. Canagliflozin tuaj yeem txo cov ntshav uric acid ntau ntau thiab txo qhov kev pheej hmoo ntawm thawj ntu thiab rov tshwm sim ntawm gout tsis zoo tshwm sim. Cov txheej txheem los ntawm SGLT2 inhibitors txo uric acid tuaj yeem ua rau kom luminal qabzib concentration, txhawb kev tawm ntawm uric acid nyob rau hauv cov tubules sib haum xeeb los ntawm GLUT9 isoform ob lossis lwm yam thauj, thiab inhibit uric acid reabsorption mediated los ntawm GLUT9 isoform 2, Li no txo ​​cov ntshav uric. acid qib.

4. Kev tiv thaiv kab mob plawv
Cov neeg mob ntshav qab zib muaj ntau yam kev pheej hmoo ntawm cov hlab plawv, thiab cov kab mob plawv tau dhau los ua qhov ua rau tuag hauv cov neeg mob T2DM. Yog li ntawd, kev kho mob yuav tsum tsis tsuas yog tswj cov ntshav qab zib hauv qhov tsim nyog tab sis kuj tswj cov hlab plawv thiab lwm yam kev pheej hmoo. Canagliflozin txo qis txoj kev pheej hmoo ntawm cov hlab plawv tuag thiab tsis tuag myocardial infarction.
Endothelial cell dysfunction yog thawj pathogenesis ntawm ntshav qab zib vascular kab mob. Canagliflozin yog ib qho inhibitor ntawm EC proliferation thiab DNA synthesis. Nws txhawb kev qhia ntawm HO-1, ib qho antioxidant enzyme nyob rau hauv vascular du leeg hlwb los ntawm txoj kev ROS-Nrf2, thiab inhibits angiogenesis. Nws tuaj yeem txhawb txoj hauv kev Akt-eNOS, inhibit p38MAPK thiab qib siab glycation kawg cov khoom lag luam-advanced glycation kawg cov khoom receptor system, txo cov kev qhia ntawm inflammatory molecules thiab oxidative stress, alleviate endothelial cell dysfunction, vascular inflammatory teb, thiab arterial kev loj hlob ntawm atherosclerosis.

Hoobkas
1. Xi'an Sonwu Biotech Co., Ltd muaj nws lub Hoobkas los tsim, tsim thiab khaws cov khoom, yog li muaj Tshuag txaus. Xi'an Sonwu muaj kev txiav txim kom zoo, huv si, thiab huv si ntau lawm. Nyob rau hauv Xi'an Sonwu, cov kws tshawb fawb tuaj yeem tsim cov khoom tshiab zoo.
2. Xi'an Sonwu muaj cov cai nruj rau cov neeg ua haujlwm faib los ntawm kev tsim khoom thiab kev sim rau kev muag khoom. Txhawm rau kom ntseeg tau tias txhua yam khoom raug thauj mus los, kev txhawb nqa cov ntaub ntawv nruj thiab kev pabcuam tom qab muag tau muab.

Daim ntawv pov thawj

Ntim

Logistics

Dhau li lav cov khoom, lwm qhov tseem ceeb tshaj plaws yog cov neeg siv khoom tuaj yeem tau txais cov khoom zoo. Yog li, Xi'an Sonwu muab txhua yam kev xa khoom raws li kev xav tau sib txawv.

FAQ
Qhov pom zoo pib koob tshuaj ntawm canagliflozin poob phaus hmoov yog 100 mg ib zaug ua ntej thawj pluas noj ntawm hnub. Rau cov neeg mob uas zam cov khoom no 100mg ib zaug ib hnub, qhov kwv yees glomerular pom tus nqi siab dua lossis sib npaug li 60mL / min / 1.73m2 thiab xav tau kev tswj glycemic ntxiv; koob tshuaj tuaj yeem nce mus rau 300mg ib hnub ib zaug. Thov ua raws li tus kws kho mob cov lus qhia kom paub meej.
Rau cov neeg mob hepatic insufficiency, cov neeg mob uas mob me mus rau nruab nrab lub siab tsis txaus yuav tsis cuam tshuam rau kev siv, thiab cov neeg mob hepatic insufficiency tsis pom zoo.
Canagliflozin nws tus kheej tsis ua rau muaj kev pheej hmoo ntawm hypoglycemia. Thaum ua ke nrog metformin, DPP4 inhibitors, thiab lwm yam tshuaj, kev pheej hmoo ntawm hypoglycemia kuj tseem qis. Txawm li cas los xij, thaum ua ke nrog sulfonylureas thiab insulin, nws tuaj yeem ua rau muaj kev pheej hmoo ntawm hypoglycemia thiab tsim nyog saib xyuas tshwj xeeb. Rau cov neeg laus noj cov tshuaj no, tshwj xeeb tshaj yog cov neeg uas muaj lub raum tsis ua hauj lwm thiab glomerular filtration rate tsawg dua 60, kuj yuav tsum tau them nyiaj mloog mus rau qhov kev pheej hmoo ntawm hypotension los ntawm cov tshuaj no.
Yog tias koj xav paub cov chaw tsim khoom canagliflozin, koj tuaj yeem tiv tauj Xi'an Sonwu. Nyem rau email ces koj tau txais high-zoocanagliflozin hmoov.
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