Everolimus hmoov

Everolimus

Everolimus hmoov, tseem hu ua RAD 001 hmoov, yog ib qho derivative ntawm sirolimus (sirolimus, tseem hu ua rapamycin, piv txwv li, rapamycin), yog li nws tseem hu ua 40-O-(2-hydroxyethyl)-rapamycin, los yog 40-O-(2-hydroxyethyl)-sirolimus. RAD 001 yog cov tshuaj siv los kho ntau yam kab mob ntawm tes thiab lwm yam kab mob. Nws cov khoom tseem ceeb yog everolimus, ib qho mTOR (mammalian lub hom phiaj ntawm rapamycin) inhibitor uas ua haujlwm los ntawm kev cuam tshuam nrog kev loj hlob ntawm tes, kev loj hlob, thiab kev ciaj sia. mTOR yog ib qho tseem ceeb ntawm serine-threonine kinase. Nws tuaj yeem khi rau cov protein intracellular FKBP12 los tsim ib qho inhibitory complex, mTORC1, uas tuaj yeem cuam tshuam cov haujlwm ntawm mTOR. Inhibition ntawm mTOR signaling txoj hauv kev tuaj yeem ua rau txo qis kev ua haujlwm ntawm transcriptional regulator S6 ribosomal protein kinase (S6K1) thiab eukaryotic elongation factor 4E-binding protein (4E-BP), yog li cuam tshuam nrog kev txhais lus thiab kev sib txuas ntawm cov proteins xws li cell. Lub voj voog, angiogenesis, thiab glycolysis. Nws tuaj yeem txo qhov kev qhia ntawm vascular endothelial kev loj hlob zoo (VEGF). RAD 001 yog ib qho muaj zog inhibitor ntawm fibroblasts, vascular du leeg hlwb, endothelial hlwb, thiab mob hlwb kev loj hlob thiab faib. Nws tuaj yeem inhibit glycolysis hauv cov kab mob hauv vitro thiab hauv vivo. Yog tias koj xav tau, Xi'an Sonwu tuaj yeem muab cov khoom siv hluav taws xob. Xi'an Sonwu tos ntsoov yuav hnov ​​​​los ntawm koj.

Certificate Of Analysis

Qhov Yuav Yuav Everolimus

Xi'an Sonwu Biotech Co. Ltd. muaj kev paub dhau los hauv kev lag luam thoob ntiaj teb thiab kev lag luam kev noj qab haus huv. Insisting rau txoj kev ntseeg raws li kev ntseeg thiab zoo ua ntej yog peb lub tuam txhab txoj cai. Peb nruj me ntsis tswj cov khoom zoo, uas txhais tau tias kev xaiv pib los ntawm raw khoom. Tsis tas li ntawd, peb tswj txhua qhov kev nthuav dav thiab txo cov nqi kom siab tshaj plaws kom peb cov neeg siv khoom tuaj yeem tau txais cov khoom lag luam zoo. Raws li cov no, cov neeg siv khoom tau muab ntau cov lus pom zoo txog peb cov khoom. Yog li nrhiav Xi'an Sonwu Biotech Co. Ltd. thaum yuav RAD 001 hmoov.

Xi'an Sonwu ua kom cov khoom zoo thiab tuaj yeem muab cov qauv. Ntawm no yog qhov ntau.

Cov neeg siv khoom 'Cov lus pom zoo

Dab tsi yog Mechanism Ntawm Kev Ua Ntawm Everolimus

Everolimus ua haujlwm los ntawm kev tiv thaiv kev ua haujlwm ntawm qhov tseem ceeb ntawm cov protein kinase hu ua mammalian lub hom phiaj ntawm rapamycin (mTOR), uas tswj kev loj hlob, faib, metabolism, thiab ciaj sia ntawm cov hlwb. Lub mechanism ntawm kev txiav txim ntawm RAD 001 muaj ob peb kauj ruam:

A. Mechanism of Action

1. Kev khi rau FKBP-12:

RAD 001 khi rau cov protein nyob hauv lub cev hu ua FK506 binding protein 12 (FKBP-12).

2. Inhibition ntawm mTORC1:

Lub everolimus-FKBP-12 complex tshwj xeeb inhibits mTOR complex 1 (mTORC1).

mTORC1 yog ib feem ntawm mTOR txoj hauv kev thiab yog lub hauv paus ntawm kev loj hlob ntawm tes, kev loj hlob, thiab kev ciaj sia regulator.

3. Cov teebmeem hauv qab:

Cell Cycle Arrest: Cells tsis tuaj yeem nce mus rau theem S, qhov twg DNA replication tshwm sim, thaum mTORC1 inhibition ua rau cell voj voog ntes nyob rau theem G1. Qhov no txo ​​cov cell proliferation.

Inhibition ntawm Protein Synthesis: mTORC1 tswj cov protein synthesis xav tau rau kev loj hlob ntawm tes thiab faib. Los ntawm inhibiting mTORC1, nws txo cov protein synthesis, ntxiv inhibiting cell loj hlob thiab proliferation.

Angiogenesis inhibition: Tsis tas li ntawd, nws tiv thaiv cov teeb meem angiogenic los ntawm kev tsim, uas txo qis kev loj hlob ntawm cov hlab ntsha tshiab uas xav tau rau kev loj hlob ntawm qhov txhab thiab metastasis.

Kev tiv thaiv kab mob tiv thaiv kab mob: Nws txo qis kev tiv thaiv kab mob rau lub cev pub dawb los ntawm kev tiv thaiv T thiab B hlwb los ntawm kev ua kom muaj zog thiab loj hlob thaum hloov pauv.

4. Autophagy induction:

Autophagy yog tshwm sim los ntawm mTORC1 inhibition thiab yog txheej txheem uas cov hlwb tawg thiab rov ua dua lawv cov khoom siv. Qhov no pab txhawb kev tshem tawm cov hlwb puas lossis cov organelles.

B. Clinical relevance

1. Kev kho kab mob ntawm tes: Hauv kev kho mob, nws tsom rau cov kab mob ntawm cov kab mob kev loj hlob thiab kev loj hlob los ntawm inhibiting mTORC1, uas feem ntau overactive hauv cov kab mob.

2. Kev Hloov Pauv: Hauv kev hloov khoom nruab nrog cev, nws pab tiv thaiv kev tsis lees paub los ntawm kev tiv thaiv lub cev tiv thaiv kab mob rau lub cev hloov pauv.

Dab tsi yog Tshuaj Everolimus siv rau

Everolimus hmoovyog siv los kho ntau yam kab mob. Cov hauv qab no yog cov kev siv tseem ceeb ntawm nws:

A. Lesion Cell Therapy

1. Advanced Renal Cell: Nws kho lub raum siab tom qab tsis ua haujlwm ntawm lwm cov kev kho mob xws li sunitinib lossis sorafenib.

2. Lub Cev Lub Cev: Nws tau ua ke nrog exemestane los kho cov tshuaj hormones receptor-zoo, HER2-cov hlwb tsis zoo hauv cov poj niam cev xeeb tub yav dhau los tau kho nrog letrozole lossis anastrozole.

3. Cov Kab Mob Neuroendocrine: Nws kho cov kab mob neuroendocrine ntawm cov kab mob pancreatic keeb kwm thiab cov kab mob tsis ua haujlwm uas tshwm sim los ntawm txoj hnyuv lossis lub ntsws.

4. Tuberous Sclerosis Complex (TSC)-Related Lesions: Nws kho TSC-related subependymal giant astrocytes (SEGA) uas xav tau kev kho mob tab sis tsis tsim nyog rau radical phais resection.

B. Kev hloov pauv

1. Kev hloov pauv raum: Nws tiv thaiv kev tsis lees paub lub cev hauv cov neeg tau txais kev hloov hauv lub raum. Nws feem ntau yog siv ua ke nrog lwm cov tshuaj tiv thaiv kab mob.

2. Kev hloov pauv daim siab: Nws kuj yog siv los tiv thaiv kev tsis lees paub lub cev hauv daim siab hloov pauv.

C. Lwm yam kab mob

Tuberous sclerosis complex (TSC): Dhau li ntawm kev kho SEGA, nws kho cov neeg mob nrog TSC-txog rau lub raum vascular du leeg nqaij rog uas tsis tas yuav phais tam sim.

RAD 001 ua haujlwm los ntawm kev tiv thaiv cov protein hu ua mammalian lub hom phiaj ntawm rapamycin (mTOR), uas tswj cov cell faib, kev loj hlob, thiab kev ciaj sia. Nws tuaj yeem pab qeeb txoj kev loj hlob thiab kev sib kis ntawm cov hlwb muaj mob thiab nres lub cev tiv thaiv kab mob los ntawm kev tawm tsam lub cev hloov pauv los ntawm kev thaiv cov txheej txheem no.

Cov zaub mov twg koj yuav tsum zam nrog Everolimus

Thaum noj RAD 001, qee yam khoom noj thiab dej haus tuaj yeem cuam tshuam nrog cov tshuaj, cuam tshuam rau nws cov txiaj ntsig lossis ua rau muaj kev pheej hmoo ntawm kev phiv. Nov yog cov ntsiab lus tseem ceeb ntawm kev noj haus:

A. Khoom noj kom zam

1. Grapefruit thiab Grapefruit Juice:

Kev sib cuam tshuam: Grapefruit thiab kua txiv hmab txiv ntoo tuaj yeem cuam tshuam cov enzyme CYP3A4, uas metabolizes nws. Qhov no yuav ua rau cov ntshav nce qib tshuaj thiab ua rau muaj feem cuam tshuam.

2. Seville txiv kab ntxwv:

Kev sib cuam tshuam: Zoo ib yam li txiv kab ntxwv qaub, Seville txiv kab ntxwv (feem ntau siv hauv marmalades) tuaj yeem cuam tshuam cov metabolism ntawm nws los ntawm CYP3A4 inhibition.

B. Cawv

Kev txiav txim siab: Txawm hais tias tsis nruj me ntsis contraindicated, cawv tuaj yeem ua rau qee qhov kev mob tshwm sim ntawm nws, xws li lub siab toxicity thiab gastrointestinal teeb meem. Nws yog qhov zoo tshaj plaws los sab laj nrog koj tus kws kho mob txog kev haus cawv thaum nws nyob.

C. Cov zaub mov muaj rog

Absorption: Cov zaub mov muaj roj ntau tuaj yeem cuam tshuam qhov nqus ntawm nws. Txawm hais tias cov lus qhia tshwj xeeb hais txog kev noj zaub mov tsis tu ncua, kev noj zaub mov tsis tu ncua yog qhov tseem ceeb los tswj cov qib tshuaj kom ruaj khov.

D. General Dietary Tips

1. Kev noj zaub mov kom zoo:

Kev noj zaub mov kom zoo tuaj yeem pab tswj cov kev tsis zoo xws li qaug zog thiab poob phaus. Xyuas kom txaus noj cov protein, txiv hmab txiv ntoo, zaub, thiab tag nrho cov nplej.

2. Dej:

Nyob twj ywm kom muaj dej zoo yog qhov tseem ceeb, tshwj xeeb tshaj yog tias muaj kev phiv xws li raws plab. Haus dej kom ntau txhua hnub.

3. Tsis txhob noj cov zaub mov nyoos los yog ua tsis tau siav:

Vim yog kev tiv thaiv kab mob, cov neeg mob yuav kis tau tus kab mob ntau dua. Tsis txhob noj nqaij nyoos los yog ua tsis tau siav, qe, nqaij nruab deg, thiab cov khoom noj siv mis uas tsis tau noj.

E. Kev sab laj nrog tus kws kho mob

Thaum siv everolimus, ib txwm tau txais kev qhia tshwj xeeb ntawm kev noj zaub mov los ntawm kws noj zaub mov lossis koj tus kws kho mob. Raws li koj qhov kev noj qab haus huv tag nrho, koj txoj kev npaj kho mob, thiab txhua qhov kev sib cuam tshuam ntawm cov tshuaj, lawv tuaj yeem muab cov lus qhia meej.

Hoobkas

1. Xi'an Sonwu muaj lub Hoobkas nrog cov khoom lag luam txaus. Tsis tas li ntawd, Xi'an Sonwu muaj chav ua haujlwm huv thiab huv si nrog cov cuab yeej siv siab heev. Raws li lub tuam txhab kev coj noj coj ua, cov kws tshawb fawb txuas ntxiv tsim cov khoom tshiab kom tau raws li cov neeg siv khoom xav tau.

2. Xi'an Sonwu muaj cov cuab yeej ntsuas qib siab thiab cov neeg ua haujlwm kuaj cov kws tshaj lij, txhua yam qhia tau tias Xi'an Sonwu lub hom phiaj muab cov ntaub ntawv raug thiab ua tau zoo thiab kev pabcuam zoo.

Daim ntawv pov thawj

Ntim

Logistics Hloov tshiab

Ntxiv nrog rau kev lees paub cov khoom zoo, lwm qhov tseem ceeb tshaj plaws yog cov neeg tau txais cov khoom lag luam zoo. Yog li, Xi'an Sonwu muab txhua yam kev xa khoom raws li kev xav tau sib txawv.

FAQ

1. Yuav nug li cas?

Peb tuaj yeem hu xov tooj, email, lossis social media.

2. Koj tuaj yeem lav qhov khoom zoo li cas?

Txhua pawg yuav tsum tau sim, thiab COA tuaj yeem muab rau cov neeg siv khoom. Tsis tas li ntawd, tag nrho cov khoom dhau qhov kev xeem: HPLC, UV, GC, TLC, thiab lwm yam. Peb koom tes nrog cov neeg thib peb, zoo li SGS.

3. Koj ntim thiab khaws cia li cas?

Pob: Siv cov khoom ntim ntim khoom ntim thiab ntim cov ntawv ntim khoom ntim, lossis ntim cov khoom raws li cov neeg siv khoom xav tau.

Cia: Koj tuaj yeem khaws cia rau hauv qhov chaw qhuav thiab txias thiab ua kom tsis txhob tshav ntuj.

Yog koj xav paub txog lubeverolimus hmoov, koj tuaj yeem tiv tauj Xi'an Sonwu. Nyem rau email, thiab tom qab ntawd koj tau txais cov hmoov zoo RAD 001.

Email:sales@sonwu.com

Cim npe nrov: Everolimus hmoov, Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, ntshiab, raw, mov, kev muag khoom