Raloxifene Hydrochloride Hmoov

Raloxifene tshuaj

Raloxifene hydrochloride hmoovyog ib qho kev xaiv estrogen receptor modulator. Cov tshuaj no cuam tshuam nrog qee qhov kev ua ntawm estrogen thiab ua rau lwm yam teebmeem ntawm estrogen. Nws muaj txiaj ntsig tiv thaiv kev mob qog nqaij hlav menopausal osteoporosis, yog li nws tuaj yeem hloov cov tshuaj estrogen los txhim kho pob txha pob txha. Nws yog hydrochloride ntsev daim ntawv ntawm raloxifene thiab muaj lipid-txo, tiv thaiv pob txha. Raloxifene hydrochloride tuaj yeem tshwj xeeb khi rau estrogen receptors hauv daim siab, pob txha, lub mis, thiab endometrium los txhawb lossis inhibit qhov kev hloov pauv ntawm cov tshuaj estrogen-tswj cov noob, yog li ua rau nws cov teebmeem agonistic lossis antagonistic. Cov tshuaj ua raws li cov tshuaj estrogen agonist hauv lipid metabolism, txo qis tag nrho thiab LDL cov roj cholesterol. Nyob rau hauv cov ntaub so ntswg xws li pob txha, nws txo cov pob txha resorption thiab pob txha turnover thiab tsub kom cov pob txha ntxhia ceev. Ua raws li cov tshuaj estrogen antagonist hauv uterine thiab cov ntaub so ntswg ntawm lub mis. Cov tshuaj kuj muaj cov tshuaj tiv thaiv kab mob hauv cov kab mob estrogen-sensitive mis.

Raloxifene hydrochloride yog ib qho tshuaj tshawb nrhiav uas tam sim no ua raws li cov tshuaj estrogen kom cov pob txha ceev. Vim yog lub luag haujlwm no, nws tau txais tos los ntawm kev ua lag luam. Xi'an Sonwu yog lub chaw tsim khoom nrog ntau tshaj kaum xyoo ntawm kev paub muab cov khoom siv raw rau kev tsim khoom. Yog tias koj tab tom nrhiav raw raloxifene hydrochloride, koj tuaj yeem tiv tauj Xi'an Sonwu.

Certificate Of Analysis

Cov neeg siv khoom 'Cov lus pom zoo

Qhov twg Yuav Raloxifene HCL

Xi'an Sonwu Biotech Co., Ltd. txoj kev lag luam koom nrog kev lag luam kho mob thoob ntiaj teb, thiab muaj kev paub dhau los hauv kev lag luam kho mob. Xi'an Sonwu tswj txhua yam khoom xim, duab, tsw, thiab lwm yam, los ntawm ntau yam los xyuas kom meej cov khoom zoo. Xi'an Sonwu siv zog ua kom nruj txhua kauj ruam, los ntawm cov khoom siv raw mus rau qhov kawg kev nthuav qhia ntawm cov khoom. Xi'an Sonwu nrhiav kev pabcuam rau txhua tus neeg siv khoom zoo thiab ua tau raws li txhua tus neeg siv khoom zoo thiab kev xav tau kev hloov kho. Yog li, yog tias koj xav tau Raloxifene HCL, thov nrhiav Xi'an Sonwu Biotech Co., Ltd.

Xi'an Sonwu ua kom cov khoom zoo thiab muab cov qauv. Ntawm no yog qhov ntau.

Dab tsi yog Cov Tshuaj Raloxifene Hydrochloride siv los kho

Raws li SERM, raloxifene muaj kev xaiv agonistic lossis antagonistic ua haujlwm ntawm cov ntaub so ntswg estrogenic. Nws yog ib qho agonist ntawm cov pob txha thiab txo tag nrho cov roj cholesterol thiab LDE-cholesterol metabolism.

1. Cov nyhuv ntawm cov pob txha:

(1) Tom qab lub cev tsis muaj zog, cov tshuaj estrogen muaj nyob rau hauv lub cev txo qis, uas ua rau muaj kev nce ntxiv hauv cov pob txha resorption, thiab muaj kev pheej hmoo ntawm pob txha poob thiab pob txha. Cov pob txha poob yog nrawm nrawm hauv thawj kaum xyoo tom qab lub cev tsis muaj zog. Txawm hais tias kev tsim cov pob txha kuj tseem ua kom nrawm dua, nws tsis txaus los them rau cov pob txha poob los ntawm kev txhim kho pob txha resorption. Lwm yam uas yuav muaj feem cuam tshuam rau pob txha pob txha muaj xws li thaum ntxov menopause, osteopenia, lub cev nyias, haiv neeg dawb thiab Neeg Esxias, thiab tsev neeg keeb kwm ntawm osteoporosis. Kev hloov kho feem ntau tuaj yeem thim rov qab cov pob txha resorption ntau dhau. Hauv cov poj niam postmenopausal nrog osteoporosis, raloxifene tuaj yeem txo qhov tshwm sim ntawm cov pob txha pob txha, tswj cov pob txha loj thiab ua kom cov pob txha pob txha pob txha. Raws li cov kev pheej hmoo no, raloxifene yog qhov tsim nyog rau kev tiv thaiv kab mob osteoporosis hauv cov poj niam nyob rau hauv kaum xyoo ntawm cov poj niam cev xeeb tub uas nws vertebral BMD nyob nruab nrab ntawm 1.0 thiab -2.5SD ntawm tus nqi nruab nrab ntawm cov tub ntxhais hluas zoo tib yam, feem ntau xav txog uas osteoporosis yuav tshwm sim nyob rau hauv lub hnub nyoog siab. Risk ntawm osteoporotic fractures. Ib yam li ntawd, raloxifene rau osteoporosis yog tsim rau cov neeg uas muaj pob txha lossis pob txha pob txha uas nws tus txha caj qaum BMD qis dua tus nqi nruab nrab ntawm -2.5 SD rau cov tub ntxhais hluas zoo tib yam, tsis hais lawv cov pob txha ntom.

(2) Raloxifene hydrochloride hmoovtxo cov pob txha resorption: cov nyhuv ntawm cov pob txha yog manifested raws li ib tug txo nyob rau hauv cov ntshav thiab cov zis pob txha turnover markers. Radioactive calcium kinetic kev tshawb fawb qhia tias cov pob txha resorption txo qis thaum BMD nce thiab qhov tshwm sim ntawm pob txha txo qis. Kev tshawb fawb ntawm raloxifene hydrochloride kev kho mob pom tau hais tias tom qab 100 postmenopausal osteoporosis cov neeg mob noj raloxifene rau rau lub hlis, femoral caj dab thiab pob txha pob txha pob txha pob txha pob txha pob txha pob txha pob txha pob txha pob txha tau nce ntau dua piv nrog ua ntej kev kho mob, thiab cov pob txha turnover markers suav nrog ntshav ALP thiab pob txha ntom. Calcium poob qis dua piv nrog ua ntej kho. Tsis muaj cov pob txha tshiab thaum kho thiab tsis pom muaj cov tshuaj tiv thaiv tsis zoo. Cov txiaj ntsig ntawm txoj kev tshawb fawb no qhia tau hais tias raloxifene hydrochloride tuaj yeem kho cov pob txha tsis zoo hauv cov poj niam postmenopausal nyob rau hauv lub xeev siab turnover, txo cov pob txha turnover tus nqi, inhibit pob txha resorption, txo txoj kev pheej hmoo ntawm pob txha, thiab nce pob txha ceev. Cov tshuaj tiv thaiv zoo thiab kev kho mob rau cov kab mob postmenopausal osteoporosis yog tsim nyog ntawm kev txhawb nqa thiab kev siv.

2. Kev cuam tshuam rau lipid metabolism thiab cov kab mob plawv: cov kev tshawb fawb soj ntsuam tau pom tias 60 mg ntawm raloxifene ib hnub twg tuaj yeem txo cov roj cholesterol tag nrho los ntawm 3 feem pua ​​-6 feem pua ​​thiab LDL-cholesterol los ntawm 4 feem pua ​​-10 feem pua. Fibrinogen txo qis tom qab peb xyoos ntawm kev kho mob raloxifene. Hauv kev tshawb fawb txog kev kho mob osteoporosis, cov neeg mob tsawg dua yuav tsum tau pib ntawm lipid-txo qis piv nrog cov placebo. Ntawm cov neeg mob uas tau cuv npe hauv Kev Tshawb Fawb Kev Kho Mob Osteoporosis, raloxifene tsis pom tias ua rau muaj kev pheej hmoo ntawm cov hlab plawv tom qab plaub xyoos ntawm kev kho mob.

Dab tsi yog Mechanism Ntawm Kev Ua Ntawm Raloxifene

Raloxifene ua haujlwm los ntawm kev khi rau estrogen receptors. Raloxifene hydrochloride yog ib tiam thib ob xaiv tshuaj estrogen receptor modulator txawv ntawm cov tshuaj los yog tshuaj hloov tshuaj hormones. Tom qab raloxifene hydrochloride khi rau estrogen receptors, nws tuaj yeem ua raws li cov tshuaj estrogen agonist rau cov pob txha hloov pauv thiab qee qhov nruab nrab ntawm cov hlab plawv, xws li ntshav lipids, lipoproteins, thiab fibrinogen. Qhov kev khi no ua rau muaj kev ua kom cov tshuaj estrogen agonism thiab thaiv cov tshuaj estrogen antagonism hauv cov ntaub so ntswg uas qhia cov tshuaj estrogen receptors. Cov receptors no tau piav qhia tias yog ob hom sib txawv, alpha estrogen receptors, thiab beta estrogen receptors. Yog li, kev qhia ntawm cov receptors no yuav hloov cov lus teb ntawm cov hlwb thiab cov ntaub so ntswg rau cov tshuaj estrogen.

Nyob rau hauv postmenopausal osteoporosis, pob txha turnover yog loj heev. Cov pob txha resorption tau nrawm dua li cov pob txha tsim, ua rau cov pob txha loj zuj zus thiab qhov ntom ntom ntom ntom. Qhov kev poob zuj zus no sawv cev rau kev pheej hmoo ntawm pob txha. Raloxifene inhibits lub sij hawm luv luv, thiab lub sij hawm ntev kom ceev cov pob txha resorption tsub kom cov pob txha ntxhia ceev, thiab txhim kho pob txha muaj zog. Lwm cov tshuaj siv los kho pob txha pob txha yog estrogens, bisphosphonates, xaiv cov tshuaj estrogen receptor modulators, parathyroid hormone, thiab calcium thiab vitamin D. Ntev ntev raloxifene tuaj yeem txo cov pob txha hloov pauv, ua kom cov pob txha pob txha ntom ntom ntawm lub cev thiab lub caj dab femoral, thiab tiv thaiv cov pob txha pob txha vertebral. Txawm li cas los xij, nws muaj cov tshuaj estrogen-antagonistic cuam tshuam rau lub tsev menyuam lossis cov ntaub so ntswg ntawm lub mis. Antagonizing estrogen txhais tau hais tias tsis txhawb kev endometrial hyperplasia thiab tsis ua rau cov ntshav los ntawm qhov chaw mos, yog li zam kev endometrial hyperplasia thiab lwm yam kab mob tshwm sim los ntawm kev kho cov tshuaj estrogen.

Cov teebmeem ntawm Evista Raloxifene

Taboo

Contraindicated nyob rau hauv cov poj niam cev xeeb tub thiab cov neeg uas muaj tam sim no los yog yav tas los venous thromboembolic teeb meem, nrog rau cov hlab ntsha sib sib zog nqus thrombosis, pulmonary embolism, thiab retinal vein thrombosis. Cov neeg uas ua xua rau cov khoom xyaw hauv raloxifene thiab cov neeg uas muaj lub siab ua haujlwm tsis zoo thiab lub raum tsis zoo yog txwv tsis pub noj. Cov neeg mob uas tsis tau piav qhia los ntshav yuav tsum tsis txhob noj.

Ceev faj

Raloxifene tuaj yeem ua rau muaj kev pheej hmoo ntawm venous thromboembolic txheej xwm, nyob rau hauv cov ntaub ntawv no cov tshuaj yuav tsum tau txiav tam sim ntawd los yog peb hnub ua ntej immobilization. Tos kom txog thaum cov xwm txheej saum toj no raug daws, lossis tus neeg mob tau txais lub xov tooj ntawm tes ua ntej pib cov khoom no.

Kev sib tshuam tshuaj

1. Kev noj tshuaj calcium carbonate ib txhij lossis tshuaj tua kab mob uas muaj txhuas thiab magnesium hydroxide tsis cuam tshuam rau kev siv raloxifene.

2. Noj raloxifene thiab warfarin ib zaug tsis hloov cov tshuaj pharmacokinetics ntawm ob lub tebchaw. Txawm li cas los xij, raloxifene tuaj yeem txo lub sijhawm prothrombin me ntsis. Yog li lub sij hawm prothrombin yuav tsum tau saib xyuas thaum raloxifene ua ke nrog warfarin lossis lwm yam coumarin derivatives. Hauv cov neeg mob twb tau txais coumarin anticoagulants, cov nyhuv ntawm raloxifene ntawm lub sijhawm prothrombin tuaj yeem tshwm sim hauv ob peb lub lis piam ntawm kev kho mob.

3. Raloxifene thiab cholestyramine yuav tsum noj nyob rau lub sijhawm sib txawv. Nws tuaj yeem txo qhov nqus thiab nkag mus rau hauv cov hlab ntshav ntawm raloxifene.

4. Kev tswj hwm ua ke nrog ampicillin yuav txo qhov siab tshaj plaws ntawm raloxifene.

5. Raloxifene tuaj yeem ua rau me ntsis nce siab ntawm cov tshuaj hormone-binding globulin, nrog rau kev sib deev hormone-binding globulin, thyroxine-binding globulin, thiab corticosteroid-binding globulin.

Tshuaj overdose

Hauv cov ntawv tshaj tawm kev lag luam tom qab muag, overdose tau tshaj tawm tsis tshua muaj. Qhov siab tshaj plaws overdose yog txog 1.5 grams. Tsis muaj kev tuag cuam tshuam txog kev noj tshuaj ntau dhau. Hauv cov neeg laus, cov tsos mob tau tshaj tawm tom qab ib koob tshuaj ntau dua 120 mg suav nrog mob ceg thiab kiv taub hau. Hauv kev tshaj tawm txog kev siv tshuaj ntau dhau hauv cov menyuam yaus hnub nyoog qis dua ob xyoos, qhov siab tshaj plaws tau hais tias koob tshuaj yog 180 mg. Cov tsos mob qhia nyob rau hauv cov me nyuam muaj xws li ataxia, kiv taub hau, ntuav, ua pob liab vog, thiab raws plab.

Hoobkas

1. Dhau li ntawm nws lub Hoobkas tsim, tsim khoom, kuaj, thiab cov khoom lag luam, Xi'an Sonwu muaj lub chaw tsim khoom zoo, huv si thiab huv si. Raws li cov txheej txheem siab ntawm Xi'an Sonwu, cov kws tshawb fawb tuaj yeem tsim cov khoom zoo tshiab.

2. Xi'an Sonwu muaj cov kev xav tau siab rau kev tshaj lij ntawm nws cov neeg ua haujlwm, txawm tias nws yog kev tsim khoom, kev sim, lossis cov neeg ua haujlwm muag khoom. Siv zog kom ntseeg tau tias txhua yam khoom raug coj los ntawm txhua yam thiab muab cov ntaub ntawv nruj thiab kev pabcuam tom qab muag.

Daim ntawv pov thawj

Ntim

Logistics

Xi'an Sonwu lav cov khoom lag luam, tab sis qhov tseem ceeb tshaj plaws yog pab cov neeg siv khoom kom tau txais cov khoom zoo. Yog li ntawd, Xi'an Sonwu muab txhua yam kev xa khoom xa tuaj raws li qhov xav tau sib txawv.

FAQ

Tej zaum yuav muaj qhov sib txawv ntawm kev siv thiab ntau npaum li cas ntawm cov khoom no nyob rau hauv ntau npaum li cas cov ntaub ntawv thiab specifications. Thov nyeem cov lus qhia tshwj xeeb los yog ua raws li tus kws kho mob cov lus qhia.

1. Cov koob tshuaj pom zoo yog 60mg / hnub. Koj tuaj yeem nqa nws yam tsis muaj kev txwv noj mov thaum nruab hnub.

2. Cov neeg laus tsis tas yuav kho cov koob tshuaj.

3. Raloxifene yuav tsum tau siv sij hawm ntev vim yog lub ntuj tsim ntawm tus kab mob.

4. Calcium thiab vitamin D feem ntau pom zoo rau cov poj niam uas noj cov calcium tsis txaus.

5. Los yog ua raws li tus kws kho mob cov lus qhia.

Yog koj txaus siab rauraloxifene hydrochloride hmoov, hu rau Xi'an Sonwu. Nrhiav email kom tau txais kev sib cuag nrog tus nqi zoo tshaj plaws raloxifene hydrochloride thiab cov chaw tsim khoom zoo.

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