Vandetanib hmoov

Yam tshuaj twg yog Vandetanib

Vandetanib hmoovyog ib qho hluavtaws aniline quinazoline compound, qhov ncauj me me molecule multi-target tyrosine kinase inhibitor, uas US FDA tau pom zoo rau lub Plaub Hlis 2011. Vandetanib, tseem hu ua Zactima thiab ZD 6474, yog thawj cov tshuaj kho mob medullary thyroid kab mob los kho qhov tsis tuaj yeem. , hauv zos advanced, los yog cov tsos mob metastatic lossis kev mob medullary thyroid kab mob. Hauv cov hlwb tsis zoo, nws tuaj yeem ua haujlwm ib txhij ntawm EGFR, VEGFR, thiab RET tyrosine kinases. Nws kuj tuaj yeem xaiv inhibit lwm yam tyrosine thiab serine / threonine kinases thiab thaiv cov teeb liab hloov nrog ntau lub hom phiaj. Yog li nws yog ib tug multi-channel phem cell signaling inhibitor.

Tam sim no, kev siv tshuaj kho mob ntawm vandetanib tsuas yog rau cov kab mob medullary thyroid. Kev nqus ntawm qhov ncauj ntawm vandetanib qeeb, txuas ntxiv, thiab nthuav dav, khi rau cov ntshav plasma proteins, thiab nws cov metabolism hauv vivo nthuav tawm cov qauv ob chav. Xi'an Sonwu, raws li cov chaw tsim khoom, nrhiav txoj hauv kev nyab xeeb thiab zoo dua los ua kom cov ntshiab vandetanib. Yog tias txaus siab rau cov khoom no, koj tuaj yeem tiv tauj Xi'an Sonwu ncaj qha.

Certificate Of Analysis

Qhov twg Yuav Vandetanib

Xi'an Sonwu Biotech Co., Ltd muaj kev paub thoob ntiaj teb hauv kev lag luam kev noj qab haus huv, txawm hais tias nws yog cov khoom siv raw khoom, cov khoom siv tshuaj kho kom haum, lossis cov kua dej kho. Xi'an Sonwu nruj me ntsis tswj cov duab, xim, tsw, thiab lwm yam ntawm cov khoom siv raw los xyuas kom meej cov khoom tsim tau raws li cov neeg siv khoom txaus siab. Xi'an Sonwu siv zog ua kom tau raws li qhov kev xav tau ntawm txhua tus neeg siv khoom, ua haujlwm rau txhua tus neeg siv khoom zoo, thiab sib tham nrog cov neeg siv khoom xaiv cov neeg nqa khoom tsim nyog raws li qhov sib txawv ntawm txhua tus neeg siv khoom. Xi'an Sonwu pib los ntawm ob yam ntawm cov khoom thiab cov kev pabcuam thiab ua haujlwm zoo hauv txhua qhov txuas kom tau raws li qhov xav tau ntawm txhua tus neeg siv khoom. Tam sim no, ntau tus neeg siv khoom tau muab cov lus pom zoo. Yog li yog tias koj xav tau vandetanib, thov nrhiav Xi'an Sonwu Biotech Co., Ltd.

Xi'an Sonwu thaum kawg ua kom cov khoom zoo thiab muab cov qauv. Ntawm no yog qhov ntau.

Cov neeg siv khoom 'Cov lus pom zoo

Vandetanib Ua Haujlwm li cas

Vandetanib yog ib qho tshiab multi-targeted kinase inhibitor uas inhibits cov dej num ntawm vascular endothelial kev loj hlob yam receptor 2 (VEGFR-2), epidermal growth factor receptor (EGFR), thiab rearranged transfection (RET) tyrosine kinases. Inhibition ntawm VEGFR2 thaiv tag nrho cov lus teb tseem ceeb phenotypic cuam tshuam nrog VEGF, suav nrog endothelial cell proliferation, migration thiab ciaj sia taus, thiab vascular permeability. EGFR signaling yog qhov tseem ceeb rau kev txhawb nqa kev loj hlob thiab kev ciaj sia ntawm ntau yam ntawm cov hlwb tsis zoo, suav nrog hauv cov kab mob ntsws tsis me me (NSCLC). RET signaling ua rau kev ua haujlwm ntawm Ras / mitogen-activated protein kinase (MAPK) thiab phosphatidylinositol-3 kinase (PI3K) / Akt channels, uas ua lub luag haujlwm tseem ceeb hauv kev loj hlob ntawm tes, sib txawv, thiab muaj sia nyob thiab cuam tshuam nrog kev loj hlob. ntawm MTC keeb kwm ntsig txog.

Vandetanib inhibits endothelial cell ciaj sia, migration, proliferation, thiab neovascularization hauv vitro angiogenesis qauv. Vandetanib nkoos tyrosine kinase phosphorylation thiab VEGF-stimulated tyrosine phosphorylation los ntawm inhibiting epidermal loj hlob factor-stimulated receptors nyob rau hauv phem hlwb thiab endothelial hlwb. Qhov tshwj xeeb ntawm vandetanib yog tias nws tsis tsuas yog inhibits EGFR tab sis kuj inhibits VEGFR-2 thiab VEGFR-3. Xws li "sab hauv" thiab "nto" spanning yog tshwj xeeb ntawm cov tshuaj tsom. "internal" thiab "sab nraud" tua cov yam ntxwv ntawm vandetanib ua rau nws muaj peev xwm mus inhibit cov qog nyob rau hauv ib nrab, yog li cov tshuaj zoo nkaus li maj mam. Txawm hais tias nws tuaj yeem txo cov qog nqaij hlav lossis txo cov qog loj, vandetanib tuaj yeem "tag nrho" cuam tshuam tus kab mob, thiab tseem yuav txo qis qee tus neeg mob cov tsos mob thawj zaug cuam tshuam nrog mob ntsws, xws li hnoos, hnoos qeev, hawb pob, hauv siab nruj, qaug zog, nyuaj pw, thiab lwm yam.

Vandetanib Sab Nraud

Cov tshuaj no feem ntau tshwm sim yog raws plab, pob khaus, pob txuv, xeev siab, ntshav siab, mob taub hau, qaug zog, tsis qab los noj mov, thiab mob plab. Feem ntau cov kev kuaj mob txawv txav tau txo qis calcium, nce ALT, thiab txo cov piam thaj.

1. Cov tawv nqaij tawv heev

2. Kab mob ntsws Interstitial

3. Ischemic cerebrovascular txheej xwm

4. Ntshav

5. Lub plawv tsis ua hauj lwm

6. Mob plab

7. Hypothyroidism

8. Ntshav siab

9. Reversible Posterior Leukoencephalopathy Syndrome

10. Kev Sib Tham Tshuaj

11. Lub raum puas

12. Kev pheej hmoo ntawm kev kho qhov txhab tsis zoo

13. Embryo-Fetal Toxicity

Hoobkas

1. Xi'an Sonwu Biotech Co., Ltd muaj lub Hoobkas los tsim, sim, thiab khaws cov khoom, yog li cov khoom muaj cov khoom tsim nyog. Xi'an Sonwu muaj lub tuam tsev tsim khoom nrog kev tswj hwm nruj. Raws li Xi'an Sonwu, cov kws tshawb fawb tuaj yeem tsim cov khoom lag luam tshiab zoo tshaj plaws.

2. Xi'an Sonwu muaj cov kev cai nruj ntawm cov neeg ua haujlwm qib los ntawm kev tsim khoom thiab kev sim, tom qab ntawd mus rau kev muag khoom. Txhawm rau kom ntseeg tau tias txhua yam khoom muaj txiaj ntsig zoo, cov neeg ua haujlwm siab tawv, kev txhawb nqa cov ntaub ntawv nruj, thiab kev pabcuam tom qab muag tau muab.

Daim ntawv pov thawj

Pob

Logistics

Xi'an Sonwu, tshwj tsis yog kev lees paub qhov ntau ntawm cov khoom, qhov tseem ceeb tshaj plaws yog pab cov neeg siv khoom kom tau txais cov khoom zoo. Yog li ntawd, Xi'an Sonwu tuaj yeem ua raws li qhov xav tau sib txawv muab txhua yam kev xa khoom raws li qhov xav tau sib txawv.

FAQ

Yog koj txaus siab rauvandetanib hmoov, koj tuaj yeem tiv tauj Xi'an Sonwu. Nyem rau email kom tau txais kev sib cuag nrog vandetanib tus nqi zoo tshaj thiab cov chaw tsim khoom zoo.

Email:sales@sonwu.com

Cim npe nrov: vandetanib hmoov, Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, ntshiab, raw, mov, kev muag khoom